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US 7,754,852 B2Granted
Natriuretic polypeptides
AssigneeMayo Foundation for Medical Education and Research
InventorsJohn C. Burnett, Jr., Candace Y. W. Lee
Life of this patent
Estimating the term…
Abstract
This document provides natriuretic polypeptides. For example, this document provides polypeptides having a natriuretic activity. In some cases, a polypeptide provided herein can have natriuretic activities, while lacking the ability to lower blood pressure. This document also provides methods and materials for inducing natriuretic activities within a mammal.
Claims19
A polypeptide less than 36 amino acid residues in length, wherein said polypeptide comprises, in an order from amino terminus to carboxy terminus:
- (a) the sequence set forth in SEQ ID NO:1 or the sequence set forth in SEQ ID NO:1 with no more than one addition, subtraction, or substitution,
- (b) the sequence set forth in SEQ ID NO:2 or the sequence set forth in SEQ ID NO:2 with no more than two additions, subtractions, or substitutions, and
- (c) the sequence set forth in SEQ ID NO:3 or the sequence set forth in SEQ ID NO:3 with no more than one addition, subtraction, or substitution.
A polypeptide comprising the sequence set forth in SEQ ID NO:4.
Dependencies are inferred from the claim text.