Papilloma virus capsomere vaccine formulations and methods of use
AssigneeLoyola University of Chicago
InventorsLutz Gissmann, Martin Muller
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Abstract
Vaccine formulations comprising viral capsomeres are disclosed along with methods for their production. Therapeutic and prophylactic methods of use for the vaccine formulations are also disclosed.
Claims14
A method for producing a vaccine formulation comprising a human papilloma virus capsomere, said capsomere comprising a fusion protein comprising a human papilloma virus L1 protein adjacent amino acid residues from a second protein, said method comprising the steps of expressing and purifying human papilloma virus L1 proteins.
A method for producing a vaccine formulation comprising a human papilloma virus capsomere, said capsomere comprising a truncated human papilloma virus L1 protein having a deletion of one or more amino acid residues necessary for formation of a virus-like particle, said method comprising the steps of expressing and purifying truncated human papilloma virus L1 proteins.
Dependencies are inferred from the claim text.