Apoptosis promoters

A compound having formula (I),

• or a therapeutically acceptable salt thereof, wherein
• A1 is A2;
• A2 is C1-C5-alkyl, C2-C5-alkenyl or C2-C5-alkynyl, each of which is substituted with R1;
• R1 is R2 or R3;
• R2 is phenyl which is unfused or fused with benzene, heteroarene or cycloalkane;
• R3 is heteroaryl which is unfused or fused with benzene;
• B1 is phenyl substituted with one F;
• and
• C1 is C(O)OH;
• wherein R2 and R3 are independently unsubstituted or substituted with one or two or three or four or five of independently selected R17, OR17, SR17, S(O)R17, SO2R17, C(O)R17, CO(O)R17, OC(O)R17, OC(O)OR17, NH2, NHR17, N(R17)2, NHC(O)R17, C(O)NH2, C(O)NHR17, C(O)N(R17)2, C(O)NHOH, C(O)NHOR17, C(O)NHSO2R17, C(O)NR17, NHSO2R17, N(SO2R17)2, SO2NH2, SO2NHR17, SO2N(R17)2, C(O)H, C(O)OH, C(N)NH2, C(N)NHR17, C(N)N(R17)2, N═NR17, CNOH, CNOCH3, OH, (O), N3, NO2, CF3, CF2CF3, CF2Cl, SO2CF3, SO2CF2CF3, SO2CF2Cl, NHSO2CF3, NHSO2CF2CF3, OCF3, OCF2CF3, F, Cl, Br or I, wherein
• R17 is R18, R20, R20 or R21;
• R18 is phenyl which is unfused or fused with benzene, heteroarene or Rl8A, wherein R18A is cycloalkane, cycloalkene, heterocycloalkane or heterocycloalkene;
• R19 is heteroaryl which is unfused or fused with benzene, heteroarene or Rl9A, wherein R19A is cycloalkane, cycloalkene, heterocycloalkane or heterocycloalkene;
• R20 is cycloalkyl, cycloalkenyl, heterocycloalkyl or heterocycloalkenyl, each of which is unfused or fused with benzene, heteroarene or R20A wherein R20A is cycloalkane, cycloalkene, heterocycloalkane or heterocycloalkene;
• R21 is alkyl, alkenyl or alkynyl, each of which is unsubstituted or substituted with one or two of independently selected alkyl, alkenyl, alkynyl, R22, OR22, NHR22, SR22, S(O)R22 or SO2R22;
• and
• R22 is phenyl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl or heterocycloalkenyl, each of which is unfused or fused with, benzene, heteroarene or R22A, wherein R22A is cycloalkane, cycloalkene, heterocycloalkane or heterocycloalkene;
• wherein the cyclic moieties represented by R18, R18A, R19, R19A, R20, R20A, R22 and R22A are independently unsubstituted or substituted with one or two or three or four or five of independently selected R23, OR23, NHR23, N(R23)2, SR23, S(O)R23 or SO2R23, CF3, CF2CF3, OH, NH2, NHCH3, N(CH3)2, N3, NO2, CF3, CF2CF3, NHSO2CF3, NHSO2CF2CF3, OCF3, OCF2CF3, F, Cl, Br or I;
• wherein
• R23 is phenyl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl or R24;
• and
• R24 is alkyl, alkenyl or alkynyl, each of which is unsubstituted or substituted with phenyl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl or heterocycloalkenyl.