Methods compositions and articles of manufacture for modulating bone growth
AssigneeYissum Research Development Company of the Hebrew University of Jerusalem
InventorsItai Bab, Raphael Mechoulam, Andreas Zimmer, Esther Shohami
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Abstract
Novel methods and pharmaceutical compositions suitable for modulating bone growth and remodeling, preventing bone diseases, inducing bone growth or repair by cannabinoid receptor-mediated effects on bone cells is disclosed. Methods of identifying bone growth modulating agents are also disclosed.
Claims9
A method of stimulating bone formation and inhibiting bone resorption in a subject having a bone disease or condition, comprising:
- administering to the subject an effective amount of a compound that stimulates bone formation and inhibits bone resorption, wherein said compound is an agonist of a cannabinoid receptor and wherein said subject having a bone disease or condition is a subject having a disease or condition selected from the group consisting of periodontal disease or defect, osteolytic bone disease other than osteoporosis, post-plastic surgery, post-orthopedic implantation, post-dental implantation, age-related osteoporosis, osteoporosis associated with post-menopausal hormone status, primary and secondary hyperparathyroidism, disuse osteoporosis, diabetes-related osteoporosis, osteoporosis associated with depression, osteoporosis associated with hypogonadism and glucocorticoid-related osteoporosis.
A method of stimulating bone formation and inhibiting bone resorption in a subject having a bone disease or condition, comprising:
- administering to the subject an effective amount of a compound that stimulates bone formation and inhibits bone resorption, wherein said compound is an agonist of a cannabinoid receptor, which agonist is selected from the group consisting of Δ9-tetrahydrocannabinol (Δ9-THC), Δ8-THC, Δ9-THC-dimethylheptyl, 11-hydroxy-Δ6-THC-dimethylheptyl (HU-210), 5′-F-Δ8-THC, 11-cannabinol, Δ8-THC-11-oic-dimethylheptyl acid, 1-deoxy-11-OH-Δ8-THC-dimethylheptyl (JWH-051), 11-hydroxy THCs, desacetyl-L-nantradol, 11-OH-cannabinol-dimethylheptyl, cannabinol-dimethylheptyl-11-oic acid, HU-308, HU 243, L-759633, L-759656, L-768242, JWH-133, JWH-139, JWH-051, JWH-015, CP55940, CP47497, CP55244, R-(+)-WIN55212, ACEA, ACPA, O-1812, arachidonyl ethanolamide (anandamide), 2-arachidonayiglycerol (2AG), 2-arachidonayiglyceryl ether, and methanandamide.
Dependencies are inferred from the claim text.