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US 7,749,745 B2Granted
Viral vectors and their use in therapeutic methods
AssigneesGeorgetown University, The General Hospital Corporation, MediGene AG
InventorsPaul Johnson, Robert L. Martuza, Samuel D. Rabkin, Tomoki Todo
Life of this patent
Estimating the term…
Abstract
The invention provides viral vectors (e.g., herpes viral vectors) and methods of using these vectors to treat disease.
Claims8
A herpes simplex-1 virus comprising (i) a mutation that consists of a deletion of the region of said virus corresponding to the BstEII-EcoNI fragment of the BamHI x fragment of F strain of herpes simplex virus I, and (ii) an inactivating mutation in the γ 34.5 neurovirulence locus of said virus and optionally an inactivating mutation elsewhere in the genome of said virus.
Dependencies are inferred from the claim text.