Back to results
US 7,749,725 B2Granted
Drug screening and diagnosis based on paracrine tubular renin-angiotensin system
AssigneeUniversity of Utah Research Foundation
InventorsAndreas Rohrwasser, Terry Morgan, Jean-Marc Lalouel
Life of this patent
Estimating the term…
Abstract
The present invention relates to a method for screening drugs for use in treating hypertension using the tubular renin-angiotensinogen system identified by the present invention. The invention further relates to a method to diagnose sodium status and sensitivity in an individual by measuring urinary angiotensinogen or angiotensin-I.
Claims5
A method for screening a drug candidate for treating hypertension or a disorder affects function of the paracrine tubule renin-angiotensin system (RAS), comprising:
- administering a drug candidate to an animal or human patient,
- measuring the amount of uncleaved urinary angiotensinogen, and comparing such amount to a control with no drug candidate,
- wherein an increase in the amount of uncleaved urinary angiotensinogen indicates the drug candidate is useful for treating hypertension or a disorder that affects function of the paracrine tubule RAS.
Dependencies are inferred from the claim text.