# US 7,746,468 B2 · Analysis system

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- Number: US 7,746,468 B2
- Document ID: US7746468B2
- Status: Granted
- Kind: B2
- Application number: 12/331,755
- Filed: 2008-12-10
- Published: 2009-06-18
- Granted: 2010-06-29
- Earliest claimed: 2007-12-13
- Assignees: Shimadzu Corporation
- Inventors: Michiaki Owa
- Web page: https://patentgrep.com/patent/US7746468B2

## CPC

- G01N 21/274: {Calibration, base line adjustment, drift correction}
- G01N 30/74: Optical detectors {(measurement of intensity, velocity, spectral content, polarisation, or phase of infrared, visible or ultraviolet light G01J)}
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)

## Abstract

Analysis system including a central control section for generally controlling the analysis that sends a command to perform a pre-injection operation, to an automatic sampler together with information designating a sample to be selected, such as an identification number, and simultaneously sends a command to perform an operation of measuring a dark current in a photodiode array (PDA) detector, to a multi-channel spectrophotometer. Thus, the automatic sampler performs the pre-injection operation, such as an operation of moving a needle to a position of a designated vial container to suck a sample, and the spectrophotometer performs the dark-current measurement operation during a time period of the pre-injection operation. After the sample is actually introduced into the column, in response to a command to perform a normal measurement operation, an operation of acquiring absorption data of an eluate from the column is started without performing the dark-current measurement operation.

## Claims

### Claim 1

An analysis system comprising:
an automatic sample feeding apparatus for selecting a designated sample from a plurality of prepared samples and reserving said selected sample as a target sample, or changing a target sample;
an optical measuring apparatus including light source means for emitting light to a sample provided by said automatic sample feeding apparatus or a sample containing components of said provided sample, and light detection means for detecting light obtained through said sample in connection with said light emitted from said light source means; and
a control apparatus for controlling said automatic sample feeding apparatus and said optical measuring apparatus,
wherein:
said optical measuring apparatus includes light blocking means adapted to be selectively interposed in a light path between said light source means and said light detection means to block off said light emitted from said light source means, and dark-current measuring means operable to measure a dark current in said light detection means under a condition that said light emitted from said light source means is blocked off by said light blocking means; and
said control apparatus is operable to control said automatic sample feeding apparatus and said optical measuring apparatus in such a manner that said optical measuring apparatus performs said operation of measuring said dark current, during a time period where said automatic sample feeding apparatus performs said operation of selecting, reserving or changing a target sample.

### Claim 2 (depends on 1)

The analysis system as defined in claim 1, which is a liquid chromatography system comprising a column for separating components of a sample provided by said automatic sample feeding apparatus, wherein:
said light source means is operable to emit light to an eluate eluted from an outlet end of said column; and
said light detection means is operable to detect transmitted light which has undergone absorption during passing of said emitted light through said eluate.

### Claim 3 (depends on 2)

The analysis system as defined in claim 2, wherein said optical measuring apparatus further includes spectral dispersion means for spectrally dispersing wavelengths of said transmitted light which has undergone absorption during passing of said emitted light through said eluate, wherein said light detection means is a photodiode array detector operable to detect light wavelength-dispersed by said spectral dispersion means.

### Claim 4 (depends on 2)

The analysis system as defined in claim 2, wherein said optical measuring apparatus further includes measurement execution means for performing an operation of normally measuring said transmitted light without performing said operation of measuring said dark current, wherein said control apparatus is operable to instruct said automatic sample feeding apparatus to selecting, reserving or change a target sample, and instruct said optical measuring apparatus to measure said dark current, and, after said automatic sample feeding apparatus completes selecting, reserving or changing said target sample, to instruct said automatic sample feeding apparatus to feed said sample to said column, and instruct said optical measuring apparatus to start said operation of normally measuring said transmitted light.