# US 7,745,655 B1 · Method for the preparation of biphosphites

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- Number: US 7,745,655 B1
- Document ID: US7745655B1
- Status: Granted
- Kind: B1
- Application number: 10/505,879
- Filed: 2002-11-28
- Granted: 2010-06-29
- Earliest claimed: 2002-03-13
- Assignees: Oxeno Olefinchemie GmbH
- Inventors: Cornelia Borgmann
- Web page: https://patentgrep.com/patent/US7745655B1

## CPC

- C07F 9/65746: {the molecule containing more than one cyclic phosphorus atom}
- C07F 9/65744: {condensed with carbocyclic or heterocyclic rings or ring systems}
- C07F: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM (metal-containing porphyrins C07D487/22)

## Abstract

The present invention relates to a process for preparing bisphosphites which contain dioxaphosphorinone units.

## Claims

### Claim 1

A process for preparing bisphosphites of the formula I
wherein R1, R2, R3, R4 are independently selected from H, aliphatic, alicyclic, aliphatic-alicyclic, heterocyclic, aliphatic-heterocyclic, aromatic, aromatic-aromatic, aliphatic-aromatic hydrocarbon radical having from 1 to 50 carbon atoms, F, Cl, Br, I, —CF3, —OR7, —COR7, —CO2R7, —CO2M, —SR7, —SO2R7, —SOR7, —SO3R7, —SO3M, —SO2NR7R8, NR7R8, N═CR7R8, or NH2, wherein R1 to R4 may be covalently linked to one another,
R7, R8 are independently selected from H or a substituted or unsubstituted, aliphatic or aromatic hydrocarbon radical having from 1 to 25 carbon atoms, atoms,
M is an alkali metal ion, alkaline earth metal ion, ammonium ion, or phosphonium ion,
Q is a divalent aliphatic, alicyclic, aliphatic-alicyclic, heterocyclic, aliphatic-heterocyclic, aromatic, or aliphatic-aromatic hydrocarbon radical having from 1 to 50 carbon atoms,
Z, Y are each Cl, Br, or I,
W, X are independently selected from an aliphatic, alicyclic, aliphatic-alicyclic, heterocyclic, aliphatic-heterocyclic, aromatic, aromatic-aromatic, or aliphatic-aromatic hydrocarbon radical having from 1 to 50 carbon atoms and may be covalently linked to one another,
the process comprising carrying out the reaction sequence
wherein the reaction steps a), b) and c) are carried out in aprotic and nonpolar solvents,
the adduct base•HY or base•HZ is filtered off after at least one of the reaction steps a), b) and c) and
the end product is isolated and purified.

### Claim 2 (depends on 1)

The process as claimed in claim 1, wherein said base comprises tertiary amines.

### Claim 3 (depends on 1)

The process as claimed in claim 1, wherein said aprotic and nonpolar solvents are at least one selected from the group consisting of benzene, toluene, ethylbenzene, and cyclohexane.

### Claim 4 (depends on 1)

The process as claimed in claim 1, wherein W and X are an independently selected from aliphatic, alicyclic, aliphaticalicyclic, heterocyclic, aliphatic-heterocyclic, aromatic, aromatic-aromatic, or aliphatic-aromatic hydrocarbon radical having from 1 to 50 carbon atoms and are covalently linked as in the formula V

### Claim 5 (depends on 1)

The process as claimed in claim 1, wherein W and X are each an aromatic hydrocarbon radical having from 1 to 50 carbon atoms and are covalently linked as shown in the formula VI
wherein R9, R10, R11, R12, R13, R14 are independently selected from H aliphatic, alicyclic, aliphatic-alicyclic, heterocyclic, aliphatic-heterocyclic, aromatic-aromatic, aromatic, aliphatic-aromatic hydrocarbon radical having from 1 to 50 carbon atoms, F, Cl, Br, I, —CF3, —OR25, —COR25, —CO2R25, —CO2M, —SR25, —SO2R25, —SOR25, —SO3R25, —SO3M, —SO2NR25R26, NR25R26, N═CR25R26, or NH2, wherein R9 to R14 may be covalently linked to one another;
R25 and R26 are independently selected from H or a substituted or unsubstituted, aliphatic or aromatic hydrocarbon radical having from 1 to 25 carbon atoms, and
M is an alkali metal ion, alkaline earth metal ion, ammonium ion, or phosphonium ion.

### Claim 6 (depends on 1)

The process as claimed in claim 1, wherein W and X are each an aromatic hydrocarbon radical having from 1 to 50 carbon atoms and are covalently linked as shown in the formula VII
wherein R9, R10, R11, R12, R13, R14, R15, R16 are independently selected from H, aliphatic, alicyclic, aliphatic-alicyclic, heterocyclic, aliphatic-heterocyclic, aromatic-aromatic, aromatic, aliphatic-aromatic hydrocarbon radical having from 1 to 50 carbon atoms, F, Cl, Br, I, —CF3, —OR25, —COR25, —CO2R25, —CO2M, —SR25, —SO2R25, —SOR25, —SO3R25, —SO3M, —SO2NR25R26, NR25R26, N═CR25R26, or NH2, wherein R9 to R16 may be covalently linked to one another,
R25 and R26 are independently selected from H or a substituted or unsubstituted, aliphatic or aromatic hydrocarbon radical having from 1 to 25 carbon atoms, and
M is an alkali metal ion, alkaline earth metal ion, ammonium ion, or phosphonium ion.

### Claim 7 (depends on 1)

The process as claimed in claim 1, wherein Q is a hydrocarbon radical of the formula VIII
wherein R17, R18, R19, R20, R21, R22, R23, R24 are independently selected from H, aliphatic, alicyclic, aliphatic-alicyclic, heterocyclic, aliphatic-heterocyclic, aromatic-aromatic, aromatic, aliphatic-aromatic hydrocarbon radical having from 1 to 50 carbon atoms, F, Cl, Br, I, —CF3, —OR25, —COR25, —CO2R25, —CO2M, —SR25, —SO2R25, —SOR25, —SO3R25, —SO3M, —SO2NR25R26, NR25R26, N═CR25R26, or NH2, wherein R17 to R24 may be covalently linked to one another,
R25 and R26 are independently selected from H or a substituted or unsubstituted, aliphatic or aromatic hydrocarbon radical having from 1 to 25 carbon atoms, and
M is an alkali metal ion, alkaline earth metal ion, ammonium ion, or phosphonium ion with the positions a and b serving as linkage points.

### Claim 8 (depends on 1)

The process as claimed in claim 1, wherein X and W are covalently linked and the corresponding starting material B used in reaction step c) is prepared according to reaction step d) in an aprotic and nonpolar solvent