# US 7,745,647 B2 · Diterpenes from the fruiting body of Antrodia camphorata and pharmaceutical compositions thereof

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- Number: US 7,745,647 B2
- Document ID: US7745647B2
- Status: Granted
- Kind: B2
- Application number: 12/318,294
- Filed: 2008-12-24
- Published: 2009-05-07
- Granted: 2010-06-29
- Earliest claimed: 2006-10-25
- Assignees: Kang Jian Biotech Corp. Ltd.
- Inventors: Min-Nan Lai; Yueh-Hsiung Kuo; Young-Ji Shiao
- Web page: https://patentgrep.com/patent/US7745647B2

## CPC

- C07D 307/33: in position 2, the oxygen atom being in its keto or unsubstituted enol form
- A61P 25/00: Drugs for disorders of the nervous system
- A61P 25/28: for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention relates to novel diterpene compounds isolated from the fruiting body of Antrodia camphorata, especially to the new compounds of following structural formula: and pharmaceutically acceptable salt, solvate, hydrate or biologically active equivalent thereof. The present invention also relates to a pharmaceutical composition containing at least one of the novel diterpene compounds, and a use of the diterpene compound as a neuroprotective agent.

## Claims

### Claim 1

A compound represented by the following structural formula (2):
wherein R is H (α, epi-α).

### Claim 2

A compound represented by the following structural formula (3):
wherein R is H (β, epi-β).

### Claim 3 (depends on 1)

The compound of claim 1, wherein the compound is isolated from the fruiting body of Antrodia camphorata.

### Claim 4 (depends on 1)

The compound of claim 1, wherein the compound is 3β, 19-dihydroxylabda-8(17), 11E-dien-16, 15-olide.

### Claim 5 (depends on 2)

The compound of claim 2, wherein the compound is 13-epi-3β, 19-dihydroxylabda-8(17), 11E-dien-16, 15-olide.

### Claim 6 (depends on 2)

The compound of claim 2, wherein the compound is 3β, 19-dihydroxylabda-8(17), 11E-dien-16, 15-olide.