# US 7,745,619 B2 · Vinca derivatives

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- Number: US 7,745,619 B2
- Document ID: US7745619B2
- Status: Granted
- Kind: B2
- Application number: 11/933,259
- Filed: 2007-10-31
- Published: 2008-05-08
- Granted: 2010-06-29
- Earliest claimed: 2003-12-04
- Assignees: Albany Molecular Research, Inc.
- Inventors: Ian L. Scott; Jeffrey M. Ralph; Matthew E. Voss
- Web page: https://patentgrep.com/patent/US7745619B2

## CPC

- C07D 519/04: Dimeric indole alkaloids, e.g. vincaleucoblastine
- A61P 3/10: for hyperglycaemia, e.g. antidiabetics
- A61P 9/00: Drugs for disorders of the cardiovascular system
- A61P 11/06: Antiasthmatics
- A61P 17/00: Drugs for dermatological disorders
- A61P 17/06: Antipsoriatics
- A61P 19/02: for joint disorders, e.g. arthritis, arthrosis
- A61P 25/28: for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A61P 27/02: Ophthalmic agents
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P 31/04: Antibacterial agents
- A61P 31/12: Antivirals
- A61P 31/18: for HIV
- A61P 31/22: for herpes viruses
- A61P 33/06: Antimalarials
- A61P 35/00: Antineoplastic agents
- A61P 35/02: specific for leukemia
- A61P 37/00: Drugs for immunological or allergic disorders
- A61P 37/08: Antiallergic agents (antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14)
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention relates to derivatives of vinca alkaloids. Pharmaceutical compositions containing these compounds as well as processes of preparation and treatment of various conditions are also disclosed.

## Claims

### Claim 1

A compound of the following chemical formula:
where:
R1 is
alkyl;
alkenyl;
alkynyl;
CN; or
SR5;
R2=alkyl or CH(O);
R5=hydrogen, alkyl, alkenyl, alkynyl, aryl, or heterocyclyl;
or a pharmaceutically acceptable salt thereof, wherein the alkyl and alkenyl groups may be branched or straight.

### Claim 2

A compound of the following chemical formula:
where:
R1=alkyl or SR5;
R5=hydrogen, alkyl, alkenyl, alkynyl, aryl, or heterocyclyl;
or a pharmaceutically acceptable salt thereof, wherein the alkyl and alkenyl groups may be branched or straight.

### Claim 3

A compound of the following chemical formula:
where:
R1=alkyl;
or a pharmaceutically acceptable salt thereof, wherein the alkyl group may be branched or straight.

### Claim 4

A compound of the following chemical formula:
where:
R5=alkyl;
or a pharmaceutically acceptable salt thereof, wherein the alkyl group may be branched or straight.