# US 7,745,613 B2 · Method for preparing peritoneal dialysate

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- Number: US 7,745,613 B2
- Document ID: US7745613B2
- Status: Granted
- Kind: B2
- Application number: 11/534,375
- Filed: 2006-09-22
- Published: 2007-01-25
- Granted: 2010-06-29
- Earliest claimed: 1998-08-24
- Assignees: Toshio Miyata; Kiyoshi Kurokawa; Tokai University Educational System
- Inventors: Toshio Miyata
- Web page: https://patentgrep.com/patent/US7745613B2

## CPC

- A61K 31/203: Retinoic acids {; Salts thereof}
- A61K 31/155: Amidines ([IMAGE cpc-sch-A61K-1029.gif]), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
- A61K 31/4965: Non-condensed pyrazines
- A61K 33/00: Medicinal preparations containing inorganic active ingredients
- A61M 1/287: {Dialysates therefor}
- A61P 7/08: Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock (artificial tears A61P27/04)
- A61P 13/12: of the kidneys
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Carbonyl compounds generated and accumulated in the peritoneal dialysate can be inactivated or eliminated by a carbonyl compound-trapping agent such as aminoguanidine. Carbonyl compounds generated during sterilization and storage of the peritoneal dialysate can be eliminated by pre-contacting with the trapping agent. Further, it is possible to eliminate carbonyl compounds transferred from the blood to the peritoneal cavity of the patient during peritoneal dialysis treatment, by adding the trapping agent to the peritoneal dialysate or by circulating the fluid through a carbonyl compound-trapping cartridge. Intraperitoneal protein modification by carbonyl compounds is inhibited by the present invention, thereby sufficiently reducing peritoneal disorders associated with peritoneal dialysis treatment.

## Claims

### Claim 1

An agent for improving intraperitoneal carbonyl-stress state during peritoneal dialysis, comprising pyridoxines or salts thereof as an active ingredient wherein the pyridoxines or salts thereof are immobilized on an insoluble carrier.

### Claim 2 (depends on 1)

The agent of claim 1, wherein the pyridoxines is pyridoxamine.

### Claim 3

A cartridge, comprising:
pyridoxines or salts thereof immobilized on the wall.

### Claim 4

A method for preparing a peritoneal dialysate, comprising:
passing a peritoneal dialysate through a cartridge, wherein the cartridge is filled with pyridoxines or salts thereof immobilized on an insoluble carrier; and
allowing carbonyl compounds in the peritoneal dialysate to be trapped by the pyridoxines or salts thereof thereby reducing carbonyl concentration in the peritoneal dialysate.

### Claim 5

A method for preparing a peritoneal dialysate having a reduced carbonyl compound content, the method comprising:
(a) contacting the peritoneal dialysate with pyridoxines or salts thereof which is immobilized on an insoluble carrier, and
(b) separating the peritoneal dialysate from the pyridoxines or salts thereof.

### Claim 6

A peritoneal dialysate present in a dual compartment container wherein a first compartment contains a reducing sugar and a second compartment contains pyridoxines or salts thereof.

### Claim 7 (depends on 3)

The cartridge of claim 3, wherein the pyridoxines is pyridoxamine.

### Claim 8 (depends on 4)

The method for preparing a peritoneal dialysate having a reduced carbonyl compound content of claim 4, wherein the pyridoxines is pyridoxamine.

### Claim 9 (depends on 5)

The method for preparing a peritoneal dialysate having a reduced carbonyl compound content of claim 5, wherein the pyridoxines is pyridoxamine.

### Claim 10 (depends on 6)

The peritoneal dialysate of a claim 6, wherein the pyridoxines is pyridoxamine.