# US 7,745,593 B2 · Feline CTLA-4 nucleic acid and polypeptides

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- Number: US 7,745,593 B2
- Document ID: US7745593B2
- Status: Granted
- Kind: B2
- Application number: 11/414,707
- Filed: 2006-04-27
- Published: 2006-08-24
- Granted: 2010-06-29
- Earliest claimed: 1998-05-01
- Assignees: The Texas A&M University System; Intervet Inc.
- Inventors: Ellen W. Collisson; Insoo Choi; Barbara J. Winslow; Mark D. Cochran
- Web page: https://patentgrep.com/patent/US7745593B2

## CPC

- C07K 14/70532: {B7 molecules, e.g. CD80, CD86}
- A61K 39/39: characterised by the immunostimulating additives, e.g. chemical adjuvants
- A61P 37/04: Immunostimulants
- A61P 37/06: Immunosuppressants, e.g. drugs for graft rejection
- A61K 38/00: Medicinal preparations containing peptides (peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00)
- A61K 2039/55516: {Proteins; Peptides}
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention provides isolated and purified DNA encoding feline CD80 (B7-1) ligand, feline CD86 (B7-2) ligand, feline CD28 receptor, or feline CTLA-4 (CD152) receptor, as well as vectors comprising nucleic acid encoding feline CD80, feline CD86, feline CD28, or feline CTLA-4. The present invention provides a host cells transformed with CD80-encoding vectors, CD86-encoding vectors, CD28-encoding vectors, or CTLA-4-encoding vectors. The invention provides polypeptides encoded by the nucleic acid of feline CD80, feline CD86, feline CD28, or feline CTLA-4. The present invention provides a vaccine comprising an effective amount of polypeptides encoded by the nucleic acid of feline CD80, feline CD86, feline CD28, or feline CTLA-4. The present invention also provides vaccines which further comprise immunogens derived from pathogens. The invention provides for vaccines capable of enhancing an immune response. The invention also provides for vaccines capable of suppressing and immune response.

## Claims

### Claim 1

An isolated nucleic acid encoding a feline CTLA-4 receptor or a feline soluble CTLA-4 receptor consisting essentially of the nucleotide sequence of SEQ ID NO: 9.

### Claim 2 (depends on 1)

The nucleic acid of claim 1, which encodes the amino acid sequence of SEQ ID NO: 10.

### Claim 3 (depends on 1)

The nucleic acid of claim 1, wherein the nucleic acid is DNA or RNA.

### Claim 4 (depends on 3)

The nucleic acid of claim 3, wherein the DNA is cDNA or genomic DNA.

### Claim 5 (depends on 1)

A method of producing a polypeptide encoded by the nucleic acid of claim 1, comprising culturing a host cell which comprises the isolated nucleic acid of claim 1; and recovering the polypeptide so produced.

### Claim 6 (depends on 2)

A method of producing a polypeptide encoded by the nucleic acid of claim 2, comprising culturing a host cell which comprises the isolated nucleic acid of claim 2; and recovering the polypeptide so produced.