# US 7,745,509 B2 · Polymer compositions with bioactive agent, medical articles, and methods > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 7,745,509 B2 - Document ID: US7745509B2 - Status: Granted - Kind: B2 - Application number: 10/728,439 - Filed: 2003-12-05 - Published: 2005-06-09 - Granted: 2010-06-29 - Earliest claimed: 2003-12-05 - Assignees: 3M Innovative Properties Company - Inventors: Scott A. Burton; Patrick D. Hyde; Prabhakara S. Rao; Caroline M. Ylitalo - Web page: https://patentgrep.com/patent/US7745509B2 ## CPC - A61L 15/22: containing macromolecular materials - A61L 15/18: containing inorganic materials - A61L 15/46: Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria - A61P 17/02: for treating wounds, ulcers, burns, scars, keloids, or the like - A61P 31/00: Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics - A61L 2300/102: Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates - A61L 2300/104: Silver, e.g. silver sulfadiazine - A61L 2300/622: Microcapsules - A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS ## Abstract A polymer composition that includes a hydrophilic polymer, an optional secondary organic polymer, and a bioactive agent distributed therein, wherein the bioactive agent is selected from the group consisting of a silver compound, a copper compound, a zinc compound, and combinations thereof. ## Claims ### Claim 1 A polymer composition comprising: a continuous hydrophobic phase comprising a mixture comprising: a hydrophobic liquid comprising mineral oil; and a hydrophobic thermoplastic elastomeric polymer; absorbent hydrophilic microparticles dispersed within the hydrophobic liquid, wherein the hydrophilic microparticles comprise a crosslinked carboxylic acid-containing organic polymer; and a bioactive agent having a particle size less than one micron dispersed in the hydrophilic microparticles, wherein the bioactive agent is selected from the group consisting of a metal oxide of silver, a metal oxide of copper, a metal oxide of zinc, and combinations thereof; wherein the polymer composition is nonadherent and contains less than 1 wt % water based on the total weight of the composition. ### Claim 2 (depends on 1) The polymer composition of claim 1 wherein the absorbent hydrophilic microparticles have an average particle size of 10 microns or less, when in a nonhydrated form. ### Claim 3 (depends on 2) The polymer composition of claim 2 wherein the absorbent hydrophilic microparticles have an average particle size of 1 micron or less, when in a nonhydrated form. ### Claim 4 (depends on 3) The polymer composition of claim 3 wherein the absorbent hydrophilic microparticles have an average particle size of 0.5 micron to 1 micron when in a nonhydrated form. ### Claim 5 (depends on 2) The polymer composition of claim 2 further comprising secondary absorbent particles having an average particle size of greater than 10 microns when in a nonhydrated form. ### Claim 6 (depends on 5) The polymer composition of claim 5 wherein the secondary absorbent particles having an average particle size of greater than 10 microns are superabsorbent. ### Claim 7 (depends on 1) The polymer composition of claim 1 wherein the microparticles are superabsorbent. ### Claim 8 (depends on 1) The polymer composition of claim 1 wherein the carboxylic acid-containing organic polymer comprises a copolymer of sodium acrylate and acrylic acid. ### Claim 9 (depends on 1) The polymer composition of claim 1 wherein the thermoplastic elastomeric polymer is selected from the group consisting of a styrene-isoprene block copolymer, a styrene-(ethylene/butylene) block copolymer, a styrene-(ethylene/propylene) block copolymer, a styrene-isoprene-styrene block copolymer, a styrene-butadiene block copolymer, a polyetherester, a poly-alpha-olefin based thermoplastic elastomeric polymer, an ethylene-1-octene copolymer, and combinations thereof. ### Claim 10 (depends on 9) The polymer composition of claim 9 wherein the thermoplastic elastomeric polymer is selected from the group consisting of styrene-isoprene-styrene (SIS), styrene-butadiene-styrene (SBS), styrene-ethylene-propylene-styrene (SEPS), styrene-ethylene-butylene-styrene (SEBS), and combinations thereof. ### Claim 11 (depends on 1) The polymer composition of claim 1 further comprising an additive selected from the group consisting of a plasticizer, a crosslinking agent, a stabilizer, an extruding aid, a filler, a pigment, a dye, a swelling agent, a foaming agent, a chain transfer agent, and combinations thereof. ### Claim 12 (depends on 1) The polymer composition of claim 1 wherein the microparticles are present in an amount of 1 wt-% to 60 wt-%, based on the total weight of the polymer composition. ### Claim 13 (depends on 1) The polymer composition of claim 1 wherein the composition is stable. ### Claim 14 (depends on 1) The polymer composition of claim 1 wherein the composition is in the form of a hydrocolloid. ### Claim 15 (depends on 1) The polymer composition of claim 1 further comprising a swelling agent. ### Claim 16 (depends on 1) The polymer composition of claim 1 wherein the bioactive agent is silver oxide. ### Claim 17 (depends on 1) A medical article comprising the polymer composition of claim 1. ### Claim 18 A polymer composition comprising: a continuous hydrophobic phase comprising a mixture comprising: mineral oil; and a hydrophobic thermoplastic elastomeric polymer selected from the group consisting of styrene-isoprene-styrene (SIS), styrene-butadiene-styrene (SBS), styrene-ethylene-propylene-styrene (SEPS), styrene-ethylene-butylene-styrene (SEBS), and combinations thereof; absorbent hydrophilic microparticles dispersed within the mineral oil, wherein the hydrophilic microparticles comprise a crosslinked carboxylic acid-containing organic polymer; and a bioactive agent having a particle size less than one micron dispersed in the hydrophilic microparticles, wherein the bioactive agent is selected from the group consisting of a metal oxide of silver, a metal oxide of copper, a metal oxide of zinc, and combinations thereof; wherein the polymer composition is nonadherent and contains less than 1 wt % water based on the total weight of the composition. ### Claim 19 (depends on 18) The polymer composition of claim 18 wherein the bioactive agent is silver oxide. ### Claim 20 (depends on 18) The polymer composition of claim 18 wherein the carboxylic acid-containing organic polymer comprises a copolymer of sodium acrylate and acrylic acid. ### Claim 21 (depends on 18) A medical article comprising the polymer composition of claim 18. ### Claim 22 A polymer composition comprising: a continuous hydrophobic phase comprising a mixture comprising: mineral oil; and a hydrophobic thermoplastic elastomeric polymer selected from the group consisting of styrene-isoprene-styrene (SIS), styrene-butadiene-styrene (SBS), styrene-ethylene-propylene-styrene (SEPS), styrene-ethylene-butylene-styrene (SEBS), and combinations thereof; absorbent hydrophilic microparticles dispersed within the mineral oil, wherein the hydrophilic microparticles comprise a crosslinked a copolymer of sodium acrylate and acrylic acid; and silver oxide having a particle size less than one micron dispersed in the hydrophilic microparticles; wherein the polymer composition is nonadherent and contains less than 1 wt % water based on the total weight of the composition. ### Claim 23 (depends on 22) A medical article comprising the polymer composition of claim 22.