# US 7,745,485 B2 · Compositions and methods for identifying agents which modulate PTEN function and PI-3 kinase pathways

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- Number: US 7,745,485 B2
- Document ID: US7745485B2
- Status: Granted
- Kind: B2
- Application number: 12/342,848
- Filed: 2008-12-23
- Published: 2009-06-25
- Granted: 2010-06-29
- Earliest claimed: 2000-05-30
- Assignees: Indiana University Research and Technology Corporation
- Inventors: Donald L. Durden
- Web page: https://patentgrep.com/patent/US7745485B2

## CPC

- G01N 33/5011: {for testing antineoplastic activity}
- A61K 38/1709: {from mammals}
- A61P 17/02: for treating wounds, ulcers, burns, scars, keloids, or the like
- A61P 35/00: Antineoplastic agents
- A61P 35/04: specific for metastasis
- A61P 37/06: Immunosuppressants, e.g. drugs for graft rejection
- A61K 48/00: Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- G01N 2500/04: Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Methods are provided for the identification, biochemical characterization and therapeutic use of agents which impact PTEN, p53, PI-kinase and AKT mediated cellular signaling.

## Claims

### Claim 1

A method for inhibiting metastasis of cancer cells in a patient in need thereof, comprising the administration of an effective amount of a PI-3 kinase inhibitor, said method further comprising assessing said patient for tumor invasion distant from site of origin following administration of said PI-3 kinase inhibitor.

### Claim 2 (depends on 1)

A method as claimed in claim 1, wherein said PI-3 kinase inhibitor effectively blocks angiogenesis.

### Claim 3 (depends on 1)

A method as claimed in claim 1, further comprising the administration of at least one additional chemotherapeutic agent.

### Claim 4 (depends on 3)

A method as claimed in claim 3, wherein said at least one additional chemotherapeutic agent is selected from the group consisting of alkylating agents, antimetabolites, asparaginase, vincristine, vinblastine, anthracyclines, microtubule disrupting agents, taxol, herceptin, and etoposides.

### Claim 5 (depends on 1)

A method as claimed in claim 1, wherein said PI-kinase inhibitor is LY294002.

### Claim 6 (depends on 1)

The method of claim 1, wherein said PI-3 kinase inhibitor is Wortmannin.