# US 7,745,484 B2 · Beta-secretase modulators and methods of use

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- Number: US 7,745,484 B2
- Document ID: US7745484B2
- Status: Granted
- Kind: B2
- Application number: 11/595,187
- Filed: 2006-11-10
- Published: 2007-08-09
- Granted: 2010-06-29
- Earliest claimed: 2005-11-21
- Assignees: Amgen Inc.
- Inventors: Wenge Zhong; Stephen Hitchcock; Brian K. Albrecht; Michael D. Bartberger; James Brown; Ryan Brown; Stuart C. Chaffee; Yuan Cheng; Michael Croghan; Russell Graceffa; Scott Harried; Dean Hickman; Dan Horne; Randall Hungate; Ted Judd; Matthew Kaller; Charles Kreiman; Daniel La; Patricia Lopez; Craig Masse; Holger Monenschein; Thomas Nguyen; Thomas Nixey; Vinod F. Patel; Lewis Pennington; Matthew Weiss; Qiufen Xue; Bryant Yang
- Web page: https://patentgrep.com/patent/US7745484B2

## CPC

- C07D 405/12: linked by a chain containing hetero atoms as chain links
- A61P 25/00: Drugs for disorders of the nervous system
- A61P 25/16: Anti-Parkinson drugs
- A61P 25/28: for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C07D 311/68: with nitrogen atoms directly attached in position 4
- C07D 413/12: linked by a chain containing hetero atoms as chain links
- C07D 491/052: the oxygen-containing ring being six-membered
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein A, B, W, R3, R4, R5, i and j are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, methods of use for these compounds, including treatment of AD and related diseases, by administering the compound(s) of Formula I, or compositions including them, to a subject. The invention also comprises further embodiments of Formulas II and III, intermediates and processes useful for the preparation of compounds of the invention.

## Claims

### Claim 1

A compound of Formula I:
or a stereoisomer, tautomer, or pharmaceutically acceptable salt, thereof, wherein
A is C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, R1-C1-10-alkyl-, R1-C2-10-alkenyl- or R1-C2-10-alkynyl-, wherein
1,2 or 3 carbon atoms of (1) said C1-C10alkyl, C1-C10 alkenyl, C1-C10 alkynyl or (2) said C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl of R1-C1-10-alkyl-, R1-C2-10-alkenyl- or R1-C2-10-alkynyl-, is optionally replaced with a heteroatom selected from O, S, S(O), S(O)2 and N, and optionally substituted independently with one or more substituents of R9; and
R1 is a fully saturated or a partially or fully unsaturated 3-8 membered monocyclic, 6-12 membered bicyclic, or 7-14 membered tricyclic ring system, said ring system formed of carbon atoms and optionally including 1-3 heteroatoms if monocyclic, 1-6 heteroatoms if bicyclic, or 1-9 heteroatoms if tricyclic, said heteroatoms selected from O, N, or S, wherein said ring system is substituted independently with one or more substituents of oxo, R7, R8, R9, NR7R7, NR7R8, OR7, SR7, OR8, SR8, C(O)R7, OC(O)R7, COOR7, C(O)R8, OC(O)R8, COOR8, C(O)NR7R7, C(S)NR7R7, NR7C(O)R7, NR7C(S)R7, NR7C(O)NR7R7, NR7C(S)NR7R7, NR7(COOR7), OC(O)NR7R7, C(O)NR7R8, C(S)NR7R8, NR7C(O)R8, NR7C(S)R8, NR7C(O)NR7R8, NR7C(S)NR7R8, NR7(COOR8), OC(O)NR7R8, S(O)2NR7R7, NR7S(O)2NR7R7, NR7S(O)2R7, S(O)2R8, S(O)2NR7R8, NR7S(O)2NR7R8 or NR7S(O)2R8;
W is —C(═O)—, or —S(═O)—b wherein b is 1 or 2;
B is R2—(CR2aR2a)h—, wherein
R2 is phenyl optionally substituted independently with 1-5 substituents of R7, R8, R9, NR7R7, NR7R8, OR7, SR7, OR8, SR8, C(O)R7, OC(O)R7, COOR7, C(O)R8, OC(O)R8, COOR8, C(O)NR7R7, C(S)NR7R7, NR7C(O)R7, NR7C(S)R7, NR7C(O)NR7R7, NR7C(S)NR7R7, NR7(COOR7), OC(O)NR7R7, C(O)NR7R8, C(S)NR7R8, NR7C(O)R8, NR7C(S)R8, NR7C(O)NR7R8, NR7C(S)NR7R8, NR7(COOR8), OC(O)NR7R8, S(O)2NR7R7, NR7S(O)2NR7R7, NR7S(O)2R7, S(O)2R8, S(O)2NR7R8, NR7S(O)2NR7R8 or NR7S(O)2R8;
each R2a, independently, is H; and
h is 1;
i is 1;
j is 0,1 or 2;
each R3, independently, is H, haloalkyl, CN, C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-10-cycloalkyl or C4-10-cycloalkenyl, each of the C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-10-cycloalkyl and C4-10-cycloalkenyl optionally comprising 1-4 heteroatoms selected from N, O and S and optionally substituted with 1-5 substituents of R8 or R9;
R4 is H, haloalkyl, CN, C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-10-cycloalkyl or C4-10-cycloalkenyl, each of the C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-10-cycloalkyl and C4-10-cycloalkenyl optionally comprising 1-4 heteroatoms selected from N, O and S and optionally substituted with 1-5 substituents of R8 or R9;
R5 is
wherein X1 is;
each X2, independently, is CR12R12;
each of Y1, Y2 and Y3, independently, is CR12R12, O or S;
m is 1; and
o is 0, 1, 2, 3, 4 or 5;
provided that (a) no more than two of Y1, Y2 and Y3 is O or S and (b) when o is 0, then each of Y1 and Y2 is CR12R12;
R7 is H, C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-10-cycloalkyl or C4-10-cycloalkenyl, each of the C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-10-cycloalkyl and C4-10-cycloalkenyl optionally comprising 1-4heteroatoms selected from N, O and S and optionally substituted with 1-5 substituents of NR8R9, NR9R9, OR8, SR8, OR9, SR9, C(O)R8, OC(O)R8, COOR8, C(O)R9, OC(O)R9, COOR9, C(O)NR8R9, C(O)NR9R9, NR9C(O)R8, NR9C(O)R9, NR9C(O)NR8R9, NR9C(O)NR9R9, NR9(COOR8), NR9(COOR9), OC(O)NR8R9, OC(O)NR9R9, S(O)2R8, S(O)2NR8R9, S(O)2R9, S(O)2NR9R9, NR9S(O)2NR8R9, NR9S(O)2NR9R9, NR9S(O)2R8, NR9S(O)2R9, R8 or R9;
R8 is a partially or fully saturated or unsaturated 3-8 membered monocyclic, 6-12 membered bicyclic, or 7-14 membered tricyclic ring system, said ring system formed of carbon atoms optionally including 1-3 heteroatoms if monocyclic, 1-6 heteroatoms if bicyclic, or 1-9 heteroatoms if tricyclic, said heteroatoms selected from O, N, or S, and wherein said ring system is optionally substituted independently with 1-5 substituents of R9, oxo, NR9R9, OR9; SR9, C(O)R9 or a partially or fully saturated or unsaturated 5-6 membered ring of carbon atoms optionally including 1-3 heteroatoms selected from O, N, or S, and optionally substituted independently with 1-5 substituents of R9;
R9 is H, halo, haloalkyl, CN, OH, NO2, NH2, acetyl, C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-10-cycloalkyl, C4-10-cycloalkenyl, C1-10-alkylamino-, C1-10-dialkylamino-, C1-10-alkoxyl, C1-10-thioalkoxyl or a saturated or partially or fully unsaturated 3-8 membered monocyclic or a 6-12 membered bicyclic, said ring system formed of carbon atoms optionally including 1-3 heteroatoms if monocyclic or 1-6 heteroatoms if bicyclic, said heteroatoms selected from O, N, or S, wherein each of the C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-10-cycloalkyl, C4-10-cycloalkenyl, C1-10-alkylamino-, C1-10-dialkylamino-, C1-10-alkoxyl, C1-10-thioalkoxyl and ring of said ring system is optionally substituted independently with 1-5substituents of halo, haloalkyl, CN, NO2, NH2, OH, oxo, methyl, methoxyl, ethyl, ethoxyl, propyl, propoxyl, isopropyl, isopropoxyl, cyclopropyl, cyclopropylmethoxyl, butyl, butoxyl, isobutoxyl, tert-butoxyl, isobutyl, sec-butyl, tert-butyl, cyclobutyl, pentyl, cyclopentyl, hexyl, cyclohexyl, C1-10-alkylamino-, C1-10-dialkylamino-, C1-10-thioalkoxyl, benzyl or phenyl;
R10 is H, halo, haloalkyl, CN, OH, NO2, NH2, acetyl, C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-10-cycloalkyl, C4-10-cycloalkenyl, C1-10-alkylamino-, C1-10-dialkylamino-, C1-10-alkoxyl, C1-10-thioalkoxyl or a saturated or partially or fully unsaturated 3-8 membered monocyclic or a 6-12 membered bicyclic, said ring system formed of carbon atoms optionally including 1-3 heteroatoms if monocyclic or 1-6 heteroatoms if bicyclic, said heteroatoms selected from O, N, or S, wherein each of the C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-10-cycloalkyl, C4-10-cycloalkenyl, C1-10-alkylamino-, C1-10-dialkylamino-, C1-10-alkoxyl, C1-10-thioalkoxyl and ring of said ring system is optionally substituted independently with 1-5 substituents of halo, haloalkyl, CN, NO2, NH2, OH, oxo, methyl, methoxyl, ethyl, ethoxyl, propyl, propoxyl, isopropyl, isopropoxyl, cyclopropyl, cyclopropylmethoxyl, butyl, butoxyl, isobutoxyl, tert-butoxyl, isobutyl, sec-butyl, tert-butyl, cyclobutyl, pentyl, cyclopentyl, hexyl, cyclohexyl, C1-10-alkylamino-, C1-10-dialkylamino-, C1-10-thioalkoxyl, benzyl or phenyl;
R11 is H halo, haloalkyl, CN, OH, NO2, NH2, acetyl, C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-10 cycloalkyl, C4-10-cycloalkenyl, C1-10-alkylamino-, C1-10-dialkylamino-, C1-10-alkoxyl, C1-10-thioalkoxyl or a saturated or partially or fully unsaturated 3-8 membered monocyclic or a 6-12 membered bicyclic, said ring system formed of carbon atoms optionally including 1-3 heteroatoms if monocyclic or 1-6heteroatoms if bicyclic, said heteroatoms selected from O, N, or S, wherein each of the C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-10-cycloalkyl, C4-10-cycloalkenyl, C1-10-alkylamino-, C1-10-dialkylamino-, C1-10-alkoxyl, C1-10-thioalkoxyl and ring of said ring system is optionally substituted independently with 1-5substituents of halo, haloalkyl, CN, NO2, NH2, OH, oxo, methyl, methoxyl, ethyl, ethoxyl, propyl, propoxyl, isopropyl, isopropoxyl, cyclopropyl, cyclopropylmethoxyl, butyl, butoxyl, isobutoxyl, tert-butoxyl, isobutyl, sec-butyl, tert-butyl, cyclobutyl, pentyl, cyclopentyl, hexyl, cyclohexyl, C1-10-alkylamino-, C1-10-dialkylamino-, C1-10-thioalkoxyl, benzyl or phenyl;
alternatively, R10 and R11taken together with the carbon or nitrogen atoms to which they are attached form a partially or fully saturated or unsaturated 5-6 membered second ring of carbon atoms optionally including 1-3 heteroatoms selected from O, N, or S, the second ring optionally substituted independently with 1-5substitutents of R12, R13, R14 or R15 and optionally fused to a 4-7 membered third ring, the third ring formed of carbon atoms optionally including 1-3 heteroatoms selected from O, N, or S, and optionally substituted independently with 1-5 substitutents of R12, R13, R14 or R15;
R12 is H, halo, haloalkyl, CN, OH, NO2, NH2, acetyl, oxo, C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-10-cycloalkyl, C4-10-cycloalkenyl, C1-10-alkylamino-, C1-10-dialkylamino-, C1-10-alkoxyl, C1-10-thioalkoxyl or a saturated or partially or fully unsaturated 3-8 membered monocyclic or a 6-12 membered bicyclic, said ring system formed of carbon atoms optionally including 1-3 heteroatoms if monocyclic or 1-6 heteroatoms if bicyclic, said heteroatoms selected from O, N, or S, wherein each of the C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-10-cycloalkyl, C4-10-cycloalkenyl, C1-10-alkylamino-, C1-10-dialkylamino-, C1-10-alkoxyl, C1-10-thioalkoxyl and ring of said ring system is optionally substituted independently with 1-5 substitutents of halo, haloalkyl, CN, NO2, NH2, OH, oxo, methyl, methoxyl, ethyl, ethoxyl, propyl, propoxyl, isopropyl, isopropoxyl, cyclopropyl, cyclopropylmethoxyl, butyl, butoxyl, isobutoxyl, tert-butoxyl, isobutyl, sec-butyl, tert-butyl, cyclobutyl, pentyl, cyclopentyl, hexyl, cyclohexyl, C1-10-alkylamino-, C1-10-dialkylamino-, C1-10-thioalkoxyl, benzyl, phenyl or R14;
R13 is NR14R15, NR15R15, OR14, SR14, OR15, SR15, C(O)R14, OC(O)R14, COOR14, C(O)R15, OC(O)R15, COOR15C(O)NR14R15, C(O)NR15R15, NR14C(O)R14, NR15C(O)R14, NR14C(O)R15, NR15C(O)R15, NR15C(O)NR14R15, NR15C(O)NR15R15, NR15(COOR14), NR15(COOR15), OC(O)NR14R15, OC(O)NR15R15, S(O)2R14, S(O)2R15, S(O)2NR14R15, S(O)2NR15R15, NR14S(O)2NR14R15, NR15S(O)2NR15R15, NR14S(O)2R14 or NR15S(O)2R15;
R14 is a saturated or partially or fully unsaturated 3-8 membered monocyclic, 6-12 membered bicyclic, or 7-14 membered tricyclic ring system, said ring system formed of carbon atoms optionally including 1-3 heteroatoms if monocyclic, 1-6 heteroatoms if bicyclic, or 1-9 heteroatoms if tricyclic, said heteroatoms selected from O, N, or S, and wherein said ring system is optionally substituted independently with 1-5 substituents of R15; and
R15 is H, halo, haloalkyl, CN, OH, NO2, NH2, oxo, acetyl, methyl, methoxyl, ethyl, ethoxyl, propyl, propoxyl, isopropyl, isopropoxyl, cyclopropyl, cyclopropylmethoxyl, butyl, butoxyl, isobutoxyl, tert-butoxyl, isobutyl, sec-butyl, tert-butyl, cyclobutyl, pentyl, cyclopentyl, hexyl, cyclohexyl, benzyl, phenyl, C1-10-alkylamino-, C1-10-dialkylamino-, C1-10-thioalkoxyl or a partially or fully saturated or unsaturated 3-8 membered monocyclic or 6-12 membered bicyclic ring system, said ring system formed of carbon atoms optionally including 1-3 heteroatoms if monocyclic or 1-6 heteroatoms if bicyclic, said heteroatoms selected from O, N, or S, and optionally substituted independently with 1-5 substituents of halo, haloalkyl, CN, NO2, NH2, OH, oxo, acetyl, methyl, methoxyl, ethyl, ethoxyl, propyl, propoxyl, isopropyl, isopropoxyl, cyclopropyl, cyclopropylmethoxyl, butyl, butoxyl, isobutoxyl, tert-butoxyl, isobutyl, sec-butyl, tert-butyl, cyclobutyl, pentyl, cyclopentyl, hexyl, cyclohexyl, benzyl or phenyl.

### Claim 2 (depends on 1)

The compound of claim 1 wherein A is C1-6-alkyl, C2-6alkenyl, C2-6-alkynyl, R1—O—C1-6-alkyl-, R1—S—C1-6-alkyl-, R1—S(O)2—C1-6-alkyl-, R1—NH—C1-6-alkyl-, R1—O—C1-6-alkenyl-, R1—S—C2-6-alkenyl-, R1—S(O)2—C2-6-alkenyl-, R1—NH—C2-6-alkenyl-, R1—O—C1-6-alkynyl-, R1—S—C1-6alkynyl-, R1—S(O)2—C1-6-alkynyl-, R1—NH—C1-6-alkynyl-, R1—C1-6alkyl-O—C1-6-alkyl-, R1—C1-6-alkyl-S—C1-6-alkyl-, R1—C1-6-alkyl-S(O)2—C1-6-alkyl-, R1—C1-6-alkyl-NH—C1-6-alkyl-, R1—C1-6-alkyl-O—C1-6-alkenyl-, R1—C1-6-alkyl-S—C2-6-alkenyl-, R1—C1-6-alkyl-S(O)2—C2-6-alkenyl-, R1—C1-6-alkyl-NH—C2-6-alkenyl-, R1—C1-6-alkyl-O—C1-6alkynyl-, R1—C1-6-alkyl-S—C1-6-alkynyl-, R1—C1-6-alkyl-S(O)2—C1-6alkynyl- or R1—C1-6-alkyl-NH—C1-6-alkynyl-.

### Claim 3 (depends on 1)

The compound of claim 1 wherein A is C1-6-alkyl, C2-6alkenyl, C2-6-alkynyl, C1-6alkyl-O—C1-3-alkyl-, C1-6-alkyl-S—C1-3-alkyl-, C1-6-alkyl-S(O)2—C1-3-alkyl-, C1-6-alkyl-NH—C1-3-alkyl, di-(C1-6-alkyl)-N—C1-3-alkyl, C2-6-alkenyl-O—C1-3-alkyl-, C2-6-alkenyl-S—C1-3-alkyl-, C2-6-alkenyl -S(O)2—C1-3-alkyl-, C2-6-alkenyl-NH—C1-3-alkyl- or C2-6-alkynyl-NH—C1-3-alkyl-, wherein the alkyl, alkenyl or alkynyl moiety of each is optionally substituted with 1-5 substituents of R9.

### Claim 4 (depends on 1)

The compound of claim 1 wherein
each R3, independently, is H, haloalkyl, CN, C1-10alkyl, C2-10-alkenyl or C2-10-alkynyl;
R4 is H or C1-10-alkyl;
h is 1;
i is 1; and
j is 0.

### Claim 5 (depends on 4)

The compound of claim 4 wherein R5 is
wherein
Z2taken together with the carbon atoms to which it is attached is a partially or fully unsaturated 5-8 membered monocyclic ring, said ring formed of carbon atoms optionally including 1-3 heteroatoms if monocyclic, 1-6 heteroatoms if bicyclic, or 1-9 heteroatoms if tricyclic, said heteroatoms selected from O, N, or S, provided that (a) no more than two of Y1, Y2 and Y3 is O or S and (b) when o is 0, then each of Y1 and Y2 is CR12R12; and
p is 0, 1, 2, 3, 4 or 5.

### Claim 6 (depends on 5)

The compound of claim 5 wherein Z2 is a phenyl, pyridine, pyrimidine, triazine, pyridazine, pyrazine, pyridone, pyrrole, imidazole, pyrazole, triazole, thiophene, thiazole, thiadiazole, isothiazole, furan, oxazole, oxadiazole or isoxazole ring.

### Claim 7 (depends on 1)

The compound of claim 1 wherein
i is 1;
j is 0;
A is C1-6-alkyl, C2-6alkenyl, C2-6-alkynyl, C1-6alkyl-O—C1-3-alkyl-, C1-6-alkyl-S—C1-3-alkyl-, C1-6-alkyl-S(O)2—C1-3-alkyl-, C1-6-alkyl-NH—C1-3-alkyl, di-(C1-6-alkyl)-N—C1-3-alkyl, C2-6-alkenyl-O—C1-3-alkyl-, C2-6-alkenyl-S—C1-3-alkyl-, C2-6-alkenyl-S(O)2—C1-3-alkyl-, C2-6-alkenyl-NH—C1-3-alkyl- or C2-6-alkynyl-NH—C1-3-alkyl-, wherein the alkyl, alkenyl or alkynyl moiety of each is optionally substituted with 1-5 substituents of R9;
W is —C(═O)—;
B is R2—(CR2aR2a)h—, wherein h is 1 and R2 is phenyl, optionally substituted with 1-5 substituents as defined in claim 1;
each R3, independently, is H, haloalkyl, CN, C1-10-alkyl, C2-10-alkenyl or C2-10-alkynyl;
R4 is H, CN or C1-10-alkyl;
R5 is
wherein m, o, R12, X2, Y1, Y2 and Y3are as defined in claim 1;
X1 is O;
Z2 is a phenyl, pyridine, pyrimidine, triazine, pyridazine, pyrazine, pyridone, pyrrole, imidazole, pyrazole, triazole, thiophene, thiazole, thiadiazole, isothiazole, furan, oxazole, oxadiazole or isoxazole ring; and
p is 0, 1, 2, 3, 4 or 5;
R7 is H, C1-10-alkyl or C2-10-alkenyl, each of the C1-10-alkyl, or C2-10-alkenyl optionally substituted with 1-3 substituents of R9;
R8 is a ring system selected from phenyl, pyridyl, pyrimidinyl, triazinyl, quinolinyl, tetrahydroquinolinyl, isoquinolinyl, tetrahydroisoquinolinyl, quinazolinyl, isoquinazolinyl, thiophenyl, furyl, tetrahydrofuranyl, pyrrolyl, pyrazolyl, thieno-pyrazolyl, imidazolyl, triazolyl, tetrazolyl, thiazolyl, thiadiazolyl, benzothiazolyl, oxazolyl, oxadiazolyl, benzoxazolyl, benzoxadiazolyl, isoxazolyl, isothiazolyl, indolyl, azaindolyl, 2,3-dihydroindolyl, isoindolyl, indazolyl, benzofuranyl, benzothiophenyl, benzimidazolyl, imidazo-pyridinyl, purinyl, benzotriazolyl, oxazolinyl, isoxazolinyl, thiazolinyl, pyrrolidinyl, pyrazolinyl, morpholinyl, piperidinyl, piperazinyl, pyranyl, dioxozinyl, 2,3-dihydro-1,4-benzoxazinyl, 1,3-benzodioxolyl, cyclopropyl, cyclobutyl, azetidinyl, cyclopentyl, cyclohexyl and cycloheptyl, said ring system optionally substituted independently with 1-3 substituents of R9, oxo, NR9R9, OR9, SR9, C(O)R9 or a partially or fully saturated or unsaturated 5-6 membered ring of carbon atoms optionally including 1-3 heteroatoms selected from O, N, or S, and optionally substituted independently with 1-5 substituents of R9;
R9 is H, halo, haloalkyl, CN, OH, NO2, NH2, acetyl, C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-7-cycloalkyl, C4-7-cycloalkenyl, C1-10-alkylamino-, C1-10-dialkylamino-, C1-10-alkoxyl, C1-10-thioalkoxyl; and
R12 is H, halo, haloalkyl, CN, OH, NO2, NH2, acetyl, oxo, C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-10-cycloalkyl, C4-10-cycloalkenyl, C1-10-alkylamino-, C1-10-dialkylamino-, C1-10-alkoxyl, C1-10-thioalkoxyl or a saturated or partially or fully unsaturated 3-8 membered monocyclic or a 6-12 membered bicyclic, said ring system formed of carbon atoms optionally including 1-3 heteroatoms if monocyclic or 1-6 heteroatoms if bicyclic, said heteroatoms selected from O, N, or S, wherein each of the C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-10-cycloalkyl, C4-10-cycloalkenyl, C1-10-alkylamino-, C1-10-dialkylamino-, C1-10-alkoxyl, C1-10-thioalkoxyl and ring of said ring system is optionally substituted independently with 1-5substituents of halo, haloalkyl, CN, NO2, NH2, OH, oxo, methyl, methoxyl, ethyl, ethoxyl, propyl, propoxyl, isopropyl, isopropoxyl, cyclopropyl, cyclopropylmethoxyl, butyl, butoxyl, isobutoxyl, tert-butoxyl, isobutyl, sec-butyl, tert-butyl, cyclobutyl, pentyl, cyclopently, hexyl, cyclohexyl, C1-10-alkylamino-, C1-10-dialkylamino-, C1-10-thioalkoxyl, benzyl or phenyl.

### Claim 8 (depends on 7)

The compound of claim 7 wherein R5 is
wherein m is 0 or 1;
o is 1 or 2;
p is 0, 1, 2 or 3;
A1 is CH, C(═O), O or NR12;
each of A1 and A2, independently, is CR12 or N, provided that no more than one of A1 and A2 is N;
X2 is CH;
Y3 is CR12 or O; and
each R12, independently, is H, halo, haloalkyl, CN, OH, NO2, NH2, acetyl, oxo, C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-10-cycloalkyl, C4-10-cycloalkenyl, C1-10-alkylamino-, C1-10-dialkylamino-, C1-10-alkoxyl, C1-10-thioalkoxyl or a ring selected from phenyl, pyridyl, pyrimidinyl, triazinyl, thiophenyl, furyl, tetrahydrofuranyl, pyrrolyl, pyrazolyl, thieno-pyrazolyl, imidazolyl, triazolyl, tetrazolyl, thiazolyl, thiadiazolyl, oxazolyl, oxadiazolyl, isoxazolyl, isothiazolyl, oxazolinyl, isoxazolinyl, thiazolinyl, pyrrolidinyl, pyrazolinyl, morpholinyl, piperidinyl, piperazinyl, pyranyl, dioxozinyl, cyclopropyl, cyclobutyl, azetidinyl, cyclopentyl, cyclohexyl and cycloheptyl, wherein each of the C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-10-cycloalkyl, C4-10-cycloalkenyl, C1-10-alkylamino-, C1-10-dialkylamino-, C1-10-alkoxyl, C1-10-thioalkoxyl and ring is optionally substituted independently with 1-5 substituents of halo, haloalkyl, CN, NO2, NH2, OH, oxo, methyl, methoxyl, ethyl, ethoxyl, propyl, propoxyl, isopropyl, isopropoxyl, cyclopropyl, cyclopropylmethoxyl, butyl, butoxyl, isobutoxyl, tert-butoxyl, isobutyl, sec-butyl, tert-butyl, cyclobutyl, pentyl, cyclopently, hexyl, cyclohexyl, C1-10-alkylamino-, C1-10-dialkylamino-, C1-10-thioalkoxyl, benzyl or phenyl.

### Claim 9

A compound, or a pharmaceutically acceptable salt thereof, selected from:
N-((1S,2R)-2-hydroxy-1-(phenylmethyl)-3-(((4S)-2,6,6-trimethyl-4,5,6,7-tetrahydro-1-benzofuran-4yl)amino)propyl)acetamide;
N-((1S,2R)-3-(((4S)-2-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1-benzothien-4yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-2-(2-oxo-1-pyrrolidinyl)acetamide;
′N-((1S,2R)-3-(((4S)-6-bromo-2,2-dimethyl-3,4-dihydro-2H-chromen-4-yl)amino)-1-((3-cyanophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4S)-6-bromo-2,2-dimethyl-3,4-dihydro-2H-chromen-4-yl)amino)-1-((3-cyanophenyl)methyl)-2-hydroxypropyl)-2-(methyloxy)acetamide;
′N˜1˜-((1S,2R)-3-(((4S)-6-bromo-2,2-dimethyl-3,4-dihydro-2H-chromen-4-yl)amino)-1-((3-cyanophenyl)methyl)-2-hydroxypropyl)-N˜2˜,N˜2˜-dimethylglycinamide;
′N-((1S,2R)-3-(((4S)-8-bromo-6-ethyl-2,2-dimethyl-3,4-dihydro-2H-chromen-4-yl)amino)-1-((3-cyanophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((3-cyanophenyl)methyl)-3-(((1S)-3,3-dimethyl-7-(methyloxy)-4-oxo-1,2,3,4-tetrahydro-1-naphthalenyl)amino)-2-hydroxypropyl)-2-(methyloxy)acetamide;
N-((1S,2R)-1-((3-cyanophenyl)methyl)-3-(((1R)-3,3-dimethyl-7-(methyloxy)-4-oxo-1,2,3,4-tetrahydro-1-naphthalenyl)amino)-2-hydroxypropyl)-2-(methyloxy)acetamide;
′N-((1S,2R)-1-((3-cyanophenyl)methyl)-3-(((1S)-3,3-dimethyl-7-(methyloxy)-4-oxo-1,2,3,4-tetrahydro-1-naphthalenyl)amino)-2-hydroxypropyl)acetamide;
N-((1S,2R)-1-((3-cyanophenyl)methyl)-3-(((1R)-3,3-dimethyl-7-(methyloxy)-4-oxo-1,2,3,4-tetrahydro-1-naphthalenyl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((3-cyanophenyl)methyl)-3-(((4S)-6-ethyl-2,2-dimethyl-8-(4-morpholinyl)-3,4-dihydro-2H-chromen-4-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4R)-6-ethyl-2,2-dimethyl-8-(1-pyrrolidinyl)-3,4-dihydro-2H-chromen-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
N-((1S,2R)-3-(((4S)-6-ethyl-2,2-dimethyl-8-(1-pyrrolidinyl)-3,4-dihydro-2H-chromen-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
′N-((1S,2R)-3-(((4S)-8-(dimethylamino)-6-ethyl-2,2-dimethyl-3,4-dihydro-2H-chromen-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
N-((1S,2R)-3-(((4R)-8-(dimethylamino)-6-ethyl-2,2-dimethyl-3,4-dihydro-2H-chromen-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
′N-((1S,2R)-3-(((4S)-6-ethyl-2,2-dimethyl-8-(methylamino)-3,4-dihydro-2H-chromen-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
′N-((1S,2R)-1-((3-cyanophenyl)methyl)-2-hydroxy-3-(((5S)-3,7,7-trimethyl-5,6,7,8-tetrahydro-5-quinolinyl)amino)propyl)acetamide;
′N-((1S,2R)-3-(((4S)-6-(2,2-dimethylpropyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]-pyridin-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
′N-((1S,2R)-3-(((4S)-6-(2,2-dimethylpropyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]-pyridin-4-yl)amino)-1-((3-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((1S)-3,3-dimethyl-7-((2-(methyloxy)ethyl)amino)-4-oxo-1,2,3,4-tetrahydro-1-naphthalenyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
N-((1S,2R)-3-(((1R)-3,3-dimethyl-7-((2-(methyloxy)ethyl)amino)-4-oxo-1,2,3,4-tetrahydro-1-naphthalenyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
′N-((1S,2R)-3-(((1R)-7-(cyclopentylamino)-3,3-dimethyl -4-oxo-1,2,3,4-tetrahydro-1-naphthalenyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
N-((1S,2R)-3-(((1S)-7-(cyclopentylamino)-3,3-dimethyl-4-oxo-1,2,3,4-tetrahydro-1-naphthalenyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
′N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-3-(((1S)-7-(2,2-dimethylpropyl)-3,3-dimethyl-4-oxo-1,2,3,4-tetrahydro-1-naphthalenyl)amino)-2-hydroxypropyl)acetamide;
N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-3-(((1R)-7-(2,2-dimethylpropyl)-3,3-dimethyl-4-oxo-1,2,3,4-tetrahydro-1-naphthalenyl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4S)-6-((2,2-dimethylpropyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-3-(((4S)-6-(2,2-dimethylpropyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4S)-2-(2,2-dimethylpropyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1-benzothien-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
′methyl((1S,2R)-3-(((4S)-2-(2,2-dimethylpropyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1-benzothien-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)carbamate;
′N-((1S,2R)-3-(((4R)-6-bromo-2,2-dimethyl-1,2,3,4-tetrahydro-4-quinolinyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
N-((1S,2R)-3-(((4S)-6-bromo-2,2-dimethyl-1,2,3,4-tetrahydro-4-quinolinyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
′N-((1S,2R)-3-(((4R)-6-(2,2-dimethylpropyl)-2,2-dimethyl-1,2,3,4-tetrahydro-4-quinolinyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
N-((1S,2R)-3-(((4S)-6-(2,2-dimethylpropyl)-2,2-dimethyl-1,2,3,4-tetrahydro-4-quinolinyl)amino)-2-hydroxy-1-(phenymethyl)propyl)acetamide;
′N-((1S,2R)-3-(((4R)-1-acetyl-6-bromo-2,2-dimethyl-1,2,3,4-tetrahydro-4-quinolinyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
N-((1S,2R)-3-(((4S)-1-acetyl-6-bromo-2,2-dimethyl-1,2,3,4-tetrahydro-4-quinolinyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
N-((1S,2R)-3-(((4S)-6-(2,2-dimethylpropyl)-2,2-dimethyl-1,2,3,4-tetrahydro-4-quinolinyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
′N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-3-(((4S)-6-(2,2-dimethylpropyl)-2,2-dimethyl-1,2,3,4-tetrahydro-4-quinolinyl)amino)-2-hydroxypropyl acetamide;
′N-((1S,2R)-3-(((4S)-6-(2,2-dimethylpropyl)-2,2-dimethyl-1,2,3,4-tetrahydro-4-quinolinyl)amino)-1-((3-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4S)-6-(2,2-dimethylpropyl)-2,2-dimethyl-1,2,3,4-tetrahydro-4-quinolinyl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((1S)-3,3-dimethyl-7-((3S)-tetrahydro-3-furanyloxy)-1,2,3,4-tetrahydro-1-naphthalenyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
′N-((1S,2R)-3-(((4S)-8-(dimethylamino)-6-(2,2-dimethylpropyl)-2,2-dimethyl-3,4-dihydro-2H -pyrano[2,3-c]pyridin-4-yl)amino)-1-((3-(dimethylamino)-5-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((3-chloro-5-fluorophenyl)methyl)-3-(((4S)-8-(dimethylamino)-6-(2,2-dimethylpropyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-c]pyridin-4-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((3,4-difluorophenyl)methyl)-3-(((4S)-6-(2,2-dimethylpropyl)-2,2-dimethyl-8-(1-pyrrolidinyl)-3,4-dihydro-2H-pyrano[2,3-c]pyridin-4-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((3,4-difluorophenyl)methyl)-3-(((4S)-6-(2,2-dimethylpropyl)-2,2-dimethyl-8-(methylamino)-3,4-dihydro-2H-pyrano[2,3-c]pyridin-4-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4S)-8-chloro-6-(2,2-dimethylpropyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-c]pyridin-4-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4S)-8-(dimethylamino)-6-(2,2-dimethylpropyl)-2,2-dimethyl-3,4-dihydro-2H -pyrano[2,3-c]pyridin-4-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4S)-6-(2,2-dimethylpropyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-c]pyridin-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
′N-((1S,2R)-1-((3-chloro-5-fluorophenyl)methyl)-3-(((4S)-6-(2,2-dimethylpropyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-c]pyridin-4-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((3-chloro-5-fluorophenyl)methyl)-3-(((4S)-6-(2,2-dimethylpropyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-c]pyridin-4-yl)amino)-2-hydroxypropyl)propanamide;
′N-((1S,2R)-3-(((4S)-6-(2,2-dimethylpropyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-c]pyridin-4-yl)amino)-1-((3-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4S)-6-(2,2-dimethylpropyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-c]pyridin-4-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-3-(((4S)-6-(2,2-dimethylpropyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-c]pyridin-4-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4S)-6-bromo-7-fluoro-2,2-dimethyl-3,4-dihydro-2H-chromen-4-yl)amino)-1-((3,5-difluorophenyl)methyl)-2-hydroxypropyl)acetamide;
N-((2S,3R)-3-hydroxy-4-((S)-6-isopropoxy-2,2-spirocyclobutyl-chroman-4-ylamino)-1-phenylbutan-2-yl)acetamide;
′N-((1S,2R)-3-(((2R,4S)-6-bromo-2-methyl-2-(trifluoromethyl)-3,4-dihydro-2H-chromen-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide; and
N-((1S,2R)-3-(((2S,4S)-6-bromo-2-methyl-2-(trifluoromethyl)-3,4-dihydro-2H-chromen-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide.

### Claim 10

A compound, or a pharmaceutically acceptable salt thereof, selected from:
N-((2S,3R)-4-(S)-2,2-spirocyclobutylchroman-4-ylamino)-3-hydroxy-1-phenylbutan-2-yl)acetamide;
N-((2S,3R)-4((S)-6-ethyl-2,2-spirocyclopentylchroman-4-ylamino)-3-hydroxy-1-phenylbutan-2-yl)acetamide.TFA salt;
N-((2S,3R)-4((S)-6-ethyl-2,2-spirocyclobutylchroman-4-ylamino)-3-hydroxy-1-phenylbutan-2-yl)-2-(pyridin-4-yl)acetamide.TFA salt;
N-((1S,2R)-3-(4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-2-(5-methyl-1H-pyrazol-1-yl)acetamide;
Methyl(2S,3R)-3-hydroxy-4-((S)-6-neopentyl-2,2-spirocyclobutyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-ylamino)-1-phenylbutan-2-ylcarbamate;
Ethyl(2S,3R)-4-((S)-6-ethyl-2,2-spirocyclobutyl-chroman-4-ylamino)-3-hydroxy-1-phenylbutan-2-ylcarbamate;
N-((2S,3R)-4-((S)-6-ethyl-2,2-spirocyclobutylchroman-4-ylamino)-3-hydroxy-1-phenylbutan-2-yl)pent-4-ynamide;
3-cyclopentyl-N-((2S,3R)-4-((S)-6-ethyl-2,2-spirocyclobutylchroman-4-ylamino)-3-hydroxy-1-phenylbutan-2-yl)propanamide;
N-((2S,3R)-4-((S)-6-ethyl-2,2-spirocyclobutylchroman-4-ylamino)-3-hydroxy-1-phenylbutan-2-yl)propionamide;
N-((2S,3R)-4-((S)-6-ethyl-2,2-spirocyclobutylchroman-4-ylamino)-3-hydroxy-1-phenylbutan-2-yl)-2-methoxyacetamide;
2-(1,3-benzothiazol-2-yloxy)-N-((1S,2R)-3-(((4S)-6-ethyl-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
N-((1S,2R)-3-(((4S)-6-ethyl-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-2-(2-oxo-1,3-oxazolidin-3-yl)acetamide;
N-((1S,2R)-3-(((4S)-6-ethyl-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-2-(1H-pyrrolo[2,3-b]pyridin-1-yl)acetamide;
N-((1S,2R)-1-((3-cyanophenyl)methyl)-3-(((4S)-6-ethyl-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)-2-hydroxypropyl)-2-(2-oxo-1,3-oxazolidin-3-yl)acetamide;
N-((1S,2R)-1-((3-cyanophenyl)methyl)-3-(((4S)-6-ethyl-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)-2-hydroxypropyl)-2-(methyloxy)acetamide;
N-((1S,2R)-1-((3-cyanophenyl)methyl)-3-(((4S)-6-ethyl-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)-2-hydroxypropyl)acetamide;
N-((1S,2R)-1-((3-cyanophenyl)methyl)-3-(((4S)-6-ethyl-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)-2-hydroxypropyl)-2-(phenyloxy)acetamide;
(3S)-N-((1S,2R)-1-((3-cyanophenyl)methyl)-3-(((4S)-6-ethyl-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)-2-hydroxypropyl)-1-cyclobutyl-5-oxo-3-pyrrolidinecarboxamide;
N-((1S,2R)-1-((3-cyanophenyl)methyl)-3-(((4S)-6-ethyl-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)-2-hydroxypropyl)propanamide;
N-((1S,2R)-1-((3-cyanophenyl)methyl)-3-(((4S)-6-ethyl-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)-2-hydroxypropyl)-2-((cyclopropylmethyl)oxy)acetamide;
N-((1S,2R)-1-((3-cyanophenyl)methyl)-3-(((2S,4S)-6-ethyl-3,4,4′,5′-tetrahydrospiro[chromene-2,3′-furan]-4-yl)amino)-2-hydroxypropyl)-2-(methyloxy)acetamide;
N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-3-(((2S,4S)-6-ethyl-3,4,4′,5′-tetrahydrospiro[chromene-2,3′-furan]-4-yl)amino)-2-hydroxypropyl)acetamide;
N-((1S,2R)-1-((3-cyanophenyl)methyl)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
2-((3-chloro-2-methylphenyl)thio)-N-((1S,2R)-3-(((4S)-6-ethyl-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-2-(1-oxo-1,3-dihydro-2H-isoindo1-2-yl)acetamide;
N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4,4′,5-tetrahydrospiro[furan-3,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxy-1-(phenylmethyl)propy1)-2-(1-oxo-1,3-dihydro-2H-isoindo1-2-yl)acetamide;
N-((1S,2R)-3-(((3S,4′S)-6′-(2,2-dimethylpropyl)-3′,4,4′,5-tetrahydrospiro[furan-3,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-2-(methyloxy)acetamide;
N-((1S,2R)-3-(4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-2-(3-methyl-5-isoxazolyl)acetamide;
N-((1S,2R)-3-(((4S)-6-ethyl-7-fluoro-3,4-dihydrospiro-2,2-spirocyclobutyl[chromene-2,1′-cyclobutan]-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-2-(2-oxo-1-pyrrolidinyl)acetamide;
N-((1S,2R)-3-(((4S)-6-ethyl-3,4-dihydrospiro-2,2-spirocyclobutyl[chromene-2,1′-cyclobutan]-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-2-(2-pyrazinyloxy)ac etamide;
N-((1S,2R)-1-((3-cyanophenyl)methyl)-3-(((4S)-6-ethyl-3,4-dihydrospiro-2,2-spirocyclobutyl[chromene-2,1′-cyclobutan]-4-yl)amino)-2-hydroxypropyl)-2-(2-pyrimidinyloxy)acetamide;
N-((1S,2R)-3-(((4S)-6-ethyl-3,4-dihydrospiro[chromene-2,1′-cyclopentan]-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-2-((5R)-2-(3-methylbutyl)-2,3,4,5-tetrahydro-1H-2-benzazepin-5-yl) acetamide;
N-((1S,2R)-3-(((4S)-6-bromo-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-2-(1H-1,2,3-triazol-4-yl)acetamide;
N-((1S,2R)-3-(((4S)-6-ethyl-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-2-(4-propyl-1H-1,2,3-triazol-1-yl)acetamide;
N-((1S,2R)-1-(3-cyanophenyl)methyl)-3-(((4′S)-6′-ethyl-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)-2-(methyloxy)acetamide;
N-((1S,2R)-2-hydroxy-3-(((4′S)-6′-(3-methylbutyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-(phenylmethyl)propyl)-2-(methyloxy)acetamide;
N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-2-(2-methyl-1,3-thiazol-4-yl)acetamide;
2-(3,5-dimethyl-4-isoxazolyl)-N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-2-(1H-1,2,4-triazol-1-yl)acetamide;
N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-2-(2H-1,2,3-triazol-2-yl)acetamide;
N-((1S,2R)-3-(((4S)-6-chloro-8-(4-morpholiny1)-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)-1-((3-cyanophenyl)methyl)-2-hydroxypropyl)acetamide;
(E)-N-((2S,3R)-4-((S)-6-ethyl-2,2-spirocyclopentylchroman-4-ylamino)-3-hydroxy-1-phenylbutan-2-yl)-3-(pyridin-2-yl)acrylamide;
N-((1S,2R)-3-(((4S)-6-ethyl-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)-2-hydroxy-1-((3-(2-propen-1-yl)phenyl)methyl)propyl)-6-heptenamide;
N-((1S,2R)-1-((1-acetyl-3-piperidinyl)methyl)-3-(((4S)-6-ethyl-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)-2-hydroxypropyl)acetamide;
N-((1S,2R)-3-(((4S)-6-ethyl-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-2-(1-oxo-1,3-dihydro-2H-isoindo1-2-yl)acetamide;
3-(1H-benzimidazol-1-yl)-N-((1S,2R)-3-(((4S)-6-ethyl-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-2-methylpropanamide;
(2E)-3-(4-bromo-2-furanyl)-N-((1S,2R)-3-(((4S)-6-ethyl-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-2-propenamide;
N-((1S,2R)-3-(((4S)-6-ethyl-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-2-(1-phthalazinylthio)acetamide;
N-((1S,2R)-3-(((4S)-6-ethyl-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-2-(2-thienylthio)propanamide;
′N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-2-hydroxy-3-(((4S)-6-(1-methyl-1H-1,2,3-triazol-4-yl)-3,4-dihydro spiro[chromene-2,1′-cyclobutan]-4-yl)amino)propyl)acetamide;
′N-((1S,2R)-2-hydroxy-3-(((4S)-6-(1-methyl-1H-1,2,3-triazol-4-yl)-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)-1-(phenylmethyl)propyl)acetamide;
′N-((1S,2R)-3-(((4S)-6-(2-fluoro-2-methylpropyl)-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
′N-((1S,2R)-3-(((4S)-6-((2R)-2-fluoropropyl)-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2-fluoro-2-methylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2-fluoro-2-methylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
′N-((1S,2R)-2-hydroxy-3-(((4′S)-6′-(2-methylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-(phenylmethyl)propyl)acetamide;
′N-((1S,2R)-1-((3-cyanophenyl)methyl)-3-(((4′S)-6′-(2-fluoro-2-methylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2-fluoro-2-methylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((3-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4S)-6-(2,2-dimethylpropyl)-8-(4-morpholinyl)-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4S)-6-(2,2-dimethylpropyl)-8-(4-morpholinyl)-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
′N-((1S)-1-((1R)-2-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-hydroxyethyl)-3-methylbutyl)acetamide;
′N-((1S)-1-((1R)-2-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-hydroxyethyl)-3-methyl-3-buten-1-yl)acetamide;
′N-((1S,2R)-1-((3-cyanophenyl)methyl)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-2-hydroxy-3-(((5′S)-3′-methyl-5′,8′-dihydro-6′H-spiro[cyclobutane-1,7′-quinolin]-5′-yl)amino)-1-(phenylmethyl)propyl)acetamide;
′N-((1S,2R)-1-((3-cyanophenyl)methyl)-2-hydroxy-3-(((5′S)-3′-methy1-5′,8′-dihydro-6′H-spiro[cyclobutane-1,7′-quinolin]-5′-yl)amino)propyl)acetamide;
′N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-2-hydroxy-3-(((4S)-6-(1,3-oxazol-2-yl)-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)propyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclopentane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclopentane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclopentane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((3-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclopropane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((4-fluoro-3-methylphenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclopent-3-ene-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-((1S)-1-fluoro-2-methylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
N-((1S,2R)-3-(((4′S)-6′-((1R)-1-fluoro-2-methylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-((1R)-1-fluoro-2-methylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-((1S)-1-fluoro-2-methylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-1)]pyridin]-4′-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-((1S)-1-fluoro-2-methylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-((1S)-1-fluoro-2-methylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-1)]pyridin]-4′-yl)amino)-1-((3-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydro-1′H-spiro[cyclobutane-1,2′-quinolin]-4′-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydro-1′H-spiro[cyclobutane-1,2′-quinolin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydro-1′H-spiro[cyclobutane-1,2′-quinolin]-4′-yl)amino)-1-((3-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((3-bromo-4-fluorophenyl)methyl)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydro-1′H-spiro[cyclobutane-1,2′-quinolin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-1′-oxo-3′,4′-dihydro-1′H-spiro[cyclopentane-1,2′-naphthalen]-4′-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′R)-6′-(2,2-dimethylpropyl)-1′-oxo-3′,4′-dihydro-1′H-spiro[cyclopentane-1,2′-naphthalen]-4′-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((3S,4′S)-6′-chloro-3′,4,4′,5-tetrahydrospiro[furan-3,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
N-((1S,2R)-3-(((3R,4′S)-6′-chloro-3′,4,4′,5-tetrahydrospiro[furan-3,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-ethyl-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((3-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((3-chloro-5-fluorophenyl)methyl)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-c]pyridin]-4′-yl)amino)-1-((3-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-c]pyridin]-4′-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2-fluoro-2-methylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2S)-3-(((4′S)-6′-(2-fluoro-2-methylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((4-fluoro-3-methylphenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((3-fluoro-4-methylphenyl)methyl)-2-hydroxypropyl)acetamide;
′methyl ((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)carbamate;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclopropane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((4-fluoro-3-methylphenyl)methyl)-3-(((4′S)-6′-(2-fluoro-2-methylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxy-1-((3-(methyloxy)phenyl)methyl)propyl)acetamide;
′N-((1S,2R)-1((4-chlorophenyl)methyl)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclopropane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethyl-3-(methyloxy)propyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-8′-(dimethylamino)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-c]pyridin]-4′-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-8′-(methylamino)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-c]pyridin]-4′-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
N-((1S,2R)-3-(((4′S)-8′-chloro-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-c]pyridin]-4′-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-8′-(ethylamino)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-c]pyridin]-4′-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-8′-((1-methylethyl)amino)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-c]pyridin]-4′-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-8′-(cyclopropylamino)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-c]pyridin]-4′-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-8′-(tetrahydro-2H-pyran-4-ylamino)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-c]pyridin]-4′-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-8′-chloro-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-c]pyridin]-4′-yl)amino)-1-((3-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-8′-(dimethylamino)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-c]pyridin]-4′-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-8′-((1,1-dimethylethyl)amino)-6′-(2,2-dimethylpropy1)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-c]pyridin]-4′-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-8′-(methylamino)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-c]pyridin]-4′-yl)amino)-1-((3-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-8′-(ethylamino)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-c]pyridin]-4′-yl)amino)-1-((3-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-8′-(tetrahydro-2H-pyran-4-ylamino)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-c]pyridin]-4′-yl)amino)-1-((3-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-8′-(dimethylamino)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-c]pyridin]-4′-yl)amino)-1-((3-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-8′-oxo-3′,4′,7′,8′-tetrahydrospiro[cyclobutane-1,2′-pyrano[2,3-c]pyridin]-4′-yl)amino)-1-((3-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′R)-6′-(2,2-dimethylpropyl)-8-((1-methylethyl)oxy)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-c]pyridin]-4′-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-8′-((1-methylethyl)oxy)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-c]pyridin]-4′-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′R)-6′-(2,2-dimethylpropyl)-8′-((1-methylethyl)oxy)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-c]pyridin]-4′-yl)amino)-1-((3-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-8′-((1-methylethyl)oxy)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-c]pyridin]-4′-yl)amino)-1-((3-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-3-(((4′R)-6′-(2,2-dimethylpropyl)-8′-((1-methylethyl)oxy)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-c]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-3-(((4′S)-6′-(2,2-dimethylpropyl)-8′-((1-methylethyl)oxy)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-c]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-3-(((4′S)-8′-(dimethylamino)-6′-(2,2-dimethylpropy1)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-c]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-8′-(dimethylamino)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-c]pyridin]-4′-yl)amino)-1-((4-(dimethylamino)phenyl)methyl)-2-hydroxypropyl)ac etamide;
′N-((1S,2R)-1-((4-chlorophenyl)methyl)-3-(((4′S)-8′-(dimethylamino)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-c]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((2,3-difluorophenyl)methyl)-3-(((4′S)-8′-(dimethylamino)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-c]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-8′-(cyclopropylamino)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-c]pyridin]-4′-yl)amino)-1-((3-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′1,1-dimethylethyl(2-(((4′S)-4′-(((2R,3S)-3-(acetylamino)-4-(3-fluorophenyl)-2-hydroxybutyl)amino)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-c]pyridin]-8′-yl)amino)ethyl)carbamate;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-8′-(3-(methyloxy)-1-azetidinyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-c]pyridin]-4′-yl)amino)-1-((3-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-8′-amino-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-c]pyridin]-4′-yl)amino)-1-((3-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-8′-((2-aminoethyl)amino)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-c]pyridin]-4′-yl)amino)-1-((3-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-8′-(methyloxy)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-c]pyridin]-4′-yl)amino)-1-((3-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′R)-6′-(2,2-dimethylpropyl)-8′-((1-methylethyl)oxy)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-c]pyridin]-4′-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-8′-((1-methylethyl)oxy)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-c]pyridin]-4′-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′R)-6′-(2,2-dimethylpropyl)-8′-((1-methylethyl)oxy)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-c]pyridin]-4′-yl)amino)-1-((3-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-8′-((1-methylethyl)oxy)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-c]pyridin]-4′-yl)amino)-1-((3-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-3-(((4′R)-6′-(2,2-dimethylpropyl)-8′-((1-methylethyl)oxy)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-c]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-3-(((4′S)-6′-(2,2-dimethylpropyl)-8′-((1-methylethyl)oxy)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-c]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-8′-(methyloxy)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-c]pyridin]-4′-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-8′-(3-(methyloxy)-1-azetidinyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-c]pyridin]-4′-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((4-fluorophenyl)methyl)-2-hydroxy-3-(((1s,3R,4′S)-3-methyl-6′-(2-methylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)propyl)acetamide;
′N-((1S,2R)-1-((4-fluorophenyl)methyl)-2-hydroxy-3-(((1r,3S,4′S)-3-methyl-6′-(2-methylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)propyl)acetamide;
′N-((1S,2R)-1-((3-fluorophenyl)methyl)-2-hydroxy-3-(((1s,3R,4′S)-3-methyl-6′-(2-methylpropy1)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)propyl)acetamide;
′N-((1S,2R)-1-((4-chlorophenyl)methyl)-2-hydroxy-3-(((1s,3R,4′S)-3-methyl-6′-(2-methylpropy1)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)propyl)acetamide;
′N-((1S,2R)-3-(((1S,2S,4′S)-6′-(2,2-dimethylpropyl)-2-methyl-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((4-chlorophenyl)methyl)-3-(((1S,2S,4′S)-6′-(2,2-dimethylpropyl)-2-methyl-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((1R,2R,4′S)-6′-(2,2-dimethylpropyl)-2-methyl-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((4-chlorophenyl)methyl)-3-(((1R,2R,4′S)-6′-(2,2-dimethylpropyl)-2-methyl-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((1S,2R,4′S)-6′-(2,2-dimethylpropyl)-2-methyl-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((4-chlorophenyl)methyl)-3-(((1S,2R,4′S)-6′-(2,2-dimethylpropyl)-2-methyl-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((1R,2S,4′S)-6′-(2,2-dimethylpropyl)-2-methyl-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((4-chlorophenyl)methyl)-3-(((1R,2S,4′S)-6′-(2,2-dimethylpropyl)-2-methyl-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′methyl((1S,2R)-1-((4-chlorophenyl)methyl)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)carbamate;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)-2-(methyloxy)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)-2-fluoroacetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)-2,2-difluoroacetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)-2,2,2-trifluoro acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)-3,3,3-trifluoropropanamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)-3-(methyloxy)propanamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxy-1-(1,3-thiazol-4-ylmethyl)propyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxy-1-(4-pyridinylmethyl)propyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxy-1-((2-propyl-1,3-thiazol-4-yl)methyl)propyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxy-1-((5-propyl-1,3-thiazol-4-yl)methyl)propyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxy-1-(1,3-thiazol-5-ylmethyl)propyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxy-1-((2-methyl-1,3-thiazol-4-yl)methyl)propyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxy-1-((2-methyl-4-pyridinyl)methyl)propyl)acetamide;
′N-((1S,2R)-1-((4-chloro-1,3-thiazol-2-yl)methyl)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((2-chloro-4-pyridinyl)methyl)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxy-1-((2-(methyloxy)-4-pyridinyl)methyl)propyl)acetamide;
′N-((1S,2R)-1-((2-chloro-6-methyl-4-pyridinyl)methyl)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxy-1-((2-((2,2,2-trifluoroethyl)oxy)-4-pyridinyl)methyl)propyl)acetamide;
′N-((1R,2S)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxy-1-(4-pyridinylmethyl)propyl)acetamide;
′N-((1S,2R)-1-(1-benzofuran-2-ylmethyl)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxy-1-((2-oxo-1,2-dihydro-4-pyridinyl)methyl)propyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxy-1-((2-(trifluoromethyl)-4-pyrimidinyl)methyl)propyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxy-1-((4-(trifluoromethyl)phenyl)methyl)propyl)acetamide;
′N-((1S,2R)-1-((4-chlorophenyl)methyl)-3-(((4′S)-6′-(2-cyano-2-methylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxy-1-((1-methyl-2-oxo-1,2-dihydro-4-pyridinyl)methyl)propyl)acetamide;
′N-((1S,2R)-1-((4-chlorophenyl)methyl)-3-(((4′S)-6′-(3,3-difluoro-2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1((4-chlorophenyl)methyl)-3-(((4′S)-6′-(2,2-dimethyl-3-butyn-1-yl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((4-chlorophenyl)methyl)-3-(((4′S)-6′-(2,2-dimethylbutyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2-cyano-2-methylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2-cyano-2-methylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((3-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(3,3-difluoro-2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
′N-((1S,2R)-3-(((4S)-2-ethyl-4,7-dihydro-5H-spiro[1-benzothiophene-6,1′-cyclobutan]-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-7′-fluoro-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
′N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-3-(((3S,4′R)-6′-(2,2-dimethylpropyl)-3′,4,4′,5-tetrahydrospiro[furan-3,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-3-(((3R,4′R)-6′-(2,2-dimethylpropyl)-3′,4,4′,5-tetrahydrospiro[furan-3,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-3-(((3S,4′S)-6′-(2,2-dimethylpropyl)-3′,4,4′,5-tetrahydrospiro[furan-3,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-3-(((3R,4′S)-6′-(2,2-dimethylpropyl)-3′,4,4′,5-tetrahydrospiro[furan-3,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((3S,4′S)-6′-(2,2-dimethylpropyl)-3′,4,4′,5-tetrahydrospiro[furan-3,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
N-((1S,2R)-3-(((3R,4′S)-6′-(2,2-dimethylpropyl)-3′,4,4,5-tetrahydrospiro[furan-3,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-3-(((4′S)-6′-(2,2-dimethylpropyl)-7′-fluoro-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((3S,4′S)-6′-(2,2-dimethylpropyl)-3′,4,4′,5-tetrahydrospiro[furan-3,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((3-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
N-((1S,2R)-3-(((3R,4′S)-6′-(2,2-dimethylpropyl)-3′,4,4′,5-tetrahydrospiro[furan-3,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((3-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-7′-fluoro-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((3-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-7′-fluoro-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((4-chlorophenyl)methyl)-3-(((3S,4′S)-6′-(2,2-dimethylpropyl)-3′,4,4′,5-tetrahydrospiro[furan-3,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
N-((1S,2R)-1-((4-chlorophenyl)methyl)-3-(((3R,4′S)-6′-(2,2-dimethylpropyl)-3′,4,4′,5-tetrahydrospiro[furan-3,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((4-chlorophenyl)methyl)-3-(((3S,4′R)-6′-(2,2-dimethylpropyl)-3′,4,4′,5-tetrahydrospiro[furan-3,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
N-((1S,2R)-1-((4-chlorophenyl)methyl)-3-(((3R,4′R)-6′-(2,2-dimethylpropyl)-3′,4,4′,5-tetrahydrospiro[furan-3,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((3-fluoro-4-(methyloxy)phenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2S)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((3-fluoro-4-(methyloxy)phenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((4-chlorophenyl)methyl)-3-(((4′S)-6′-(2,2-dimethylpropyl)-7′-fluoro-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1R,2S)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((3-fluoro-4-(trifluoromethyl)phenyl)methyl)-2-hydroxypropyl)acetamide;
N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((3-fluoro-4-(trifluoromethyl)phenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-((1R)-1-fluoro-2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
N-((1S,2R)-3-(((4′S)-6′-((1S)-1-fluoro-2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((4-chlorophenyl)methyl)-3-(((3S,4′S)-6′-(2,2-dimethylpropyl)-3′,4,4′,5-tetrahydrospiro[furan-3,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((4-chlorophenyl)methyl)-3-(((3R,4′S)-6′-(2,2-dimethylpropyl)-3′,4,4′,5-tetrahydrospiro[furan-3,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((3S,4′S)-6′-(2,2-dimethylpropyl)-3′,4,4′,5-tetrahydrospiro[furan-3,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((3R,4′S)-6′-(2,2-dimethylpropyl)-3′,4,4′,5-tetrahydrospiro[furan-3,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((4-chlorophenyl)methyl)-3-(((4′S)-6′-((1R)-1-fluoro-2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
N-((1S,2R)-1-((4-chlorophenyl)methyl)-3-(((4′S)-6′-((1S)-1-fluoro-2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-((1S)-1-fluoro-2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-((1R)-1-fluoro-2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1((4-fluoro-3-(trifluoromethyl)phenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((2,3-difluorophenyl)methyl)-3-(((4′S)-6′-((1R)-1-fluoro-2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-((1R)-1-fluoro-2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1′-(3-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-((1R)-1-fluoro-2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
′N-((1S,2R)-1-((4-chlorophenyl)methyl)-3-(((4′S)-6′-((1R)-1-fluoro-2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-3-(((4′S)-6′-((1R)-1-fluoro-2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(cyclobutylmethyl)-3′, 4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((5R,5aS)-3-(2,2-dimethylpropyl)-5a,6,7,8-tetrahydro-5H-pyrrolo[1′,2′:1,5]pyrrolo[2,3-b]pyridin-5-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((4-fluorophenyl)methyl)-2-hydroxy-3-(((4′S)-6′-(1-hydroxypentyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)propyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxy-1-((2,4,5-trifluorophenyl)methyl)propyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxy-1-((3,4,5-trifluorophenyl)methyl)propyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(cyclopropylmethyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((4-fluorophenyl)methyl)-2-hydroxy-3-(((4′S)-6′-((1-methylcyclopropyl)methyl) -3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)propyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(3,3-difluoro-2-methylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(cyclopropylmethyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((3,5-difluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-((2S)-3-fluoro-2-methylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
N-((1S,2R)-3-(((4′S)-6′-((2R)-3-fluoro-2-methylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-3-(((4′S)-6′-(2-ethylbutyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1((4-fluorophenyl)methyl)-2-hydroxy-3-(((4′S)-6′-propyl-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)propyl)acetamide;
′N-((1S,2R)-1-((4-fluorophenyl)methyl)-2-hydroxy-3-(((4′S)-6′-((2S)-2-methylbutyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)propyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-butyl-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((4-fluorophenyl)methyl)-2-hydroxy-3-(((4′S)-6′-(2-methyl-1-propen-1-yl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)propyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropanoyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′2-azido-N-((1S,2R)-3-(((4S)-6-bromo-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino) -2-hydroxy-1-(phenylmethyl)propyl)acetamide;
′N-((1S,2R)-1((3-cyanophenyl)methyl)-2-hydroxy-3-(((4′S)-6′-(trifluoromethyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)propyl)acetamide;
′N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-2-hydroxy-3 -(((4′S)-6′-(trifluoromethyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)propyl)acetamide;
′N-((1S,2R)-1-((3,4-difluorophenyl)methyl)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((3-chlorophenyl)methyl)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((2-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((2,4-difluorophenyl)methyl)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S)-1-((1R)-2-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-hydroxyethyl)-3-pentyn-1-yl)acetamide;
′N-((1S,2R)-1-((3-chloro-4-fluorophenyl)methyl)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((4-chlorophenyl)methyl)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((2-chlorophenyl)methyl)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((3-(dimethylamino)-4-fluorophenyl)methyl)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((3-(ethylamino)-4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((3,4-dichlorophenyl)methyl)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxy-1-((4-((trifluoromethyl)oxy)phenyl)methyl)propyl)acetamide;
N-((1S,2R)-1-((3-chloro-4-fluorophenyl)methyl)-3-(((1s,3R,4′S)-6′-(2,2-dimethylpropyl)-3-methyl-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
N-((1S,2R)-1-((4-chlorophenyl)methyl)-3-(((1s,3R,4′S)-6′-(2,2-dimethylpropyl)-3-methyl-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S)-1-((1R)-2-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-hydroxyethyl)-4-penten-1-yl)acetamide;
′N-((1S,2R)-1-((4-chloro-3-(trifluoromethyl)phenyl)methyl)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S)-1-((1R)-2-(((1s,3R,4′S)-6′-(2,2-dimethylpropyl)-3-methyl-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-hydroxyethyl)-4-penten-1-yl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxy-1-((3-(trifluoromethyl)phenyl)methyl)propyl)acetamide;
′N-((1S,2R)-2-hydroxy-3-(((4′S)-6′-(2-methylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((3-(trifluoromethyl)phenyl)methyl)propyl)acetamide;
′N-((1S,2R)-1-((4-chloro-3-fluorophenyl)methyl)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((4-chloro-3-(methyloxy)phenyl)methyl)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-(cyclopropylmethyl)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxy-1-((2-methylcyclopropyl)methyl)propyl)acetamide;
′N-((1S,2R)-1-(cyclopropylmethyl)-3-(((4′S)-6′-(4,4-difluoro-2,2-dimethylbutyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-(cyclopropylmethyl)-3-(((1s,3R,4′S)-6′-(2,2-dimethylpropyl)-3-methyl-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((2-((difluoromethyl)oxy)-4-pyridinyl)methyl)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N˜1˜-((1S,2R)-3-(((4S)-6-bromo-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)-1-((3-cyanophenyl)methyl)-2-hydroxypropyl)-N˜2˜,N˜2˜-dimethylglycinamide;
′methyl(4S)-4-(((2R,3S)-4-(3-cyanophenyl)-3-((N,N-dimethylglycyl)amino)-2-hydroxybutyl)amino)-3,4-dihydrospiro[chromene-2,1′-cyclobutane]-6-carb oxylate;
′methyl(4S)-4-(((2R,3S)-3-(acetylamino)-4-(3-cyanophenyl)-2-hydroxybutyl)amino)-3,4-dihydrospiro[chromene-2,1′-cyclobutane]-6-carb oxylate;
′methyl(4S)-4-(((2R,3S)-4-(3-cyanophenyl)-2-hydroxy-3-(((methyloxy)acetyl)amino)butyl)amino)-3,4-dihydrospiro[chromene-2,1′-cyclobutane]-6-carboxylate;
′N-((1S,2R)-3-(((4S)-6-ethyl-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)-2-hydroxy-1-((methyloxy)methyl)propyl)acetamide;
′N-((1S,2R)-3-(((4S)-6-ethyl-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)-2-hydroxy-1-((propyloxy)methyl)propyl)acetamide;
′N-((1S,2R)-3-(((4S)-6-ethyl-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)-2-hydroxy-1-(((phenylmethyl)oxy)methyl)propyl)acetamide;
′N-((1S,2R)-3-(((4S)-6-ethyl-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)-2-hydroxy-1-(1H-pyrazol-1-ylmethyl)propyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxy-1-(1H-pyrazol-1-ylmethyl)propyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxy-1-((2-propen-1-yloxy)methyl)propyl)acetamide;
′N-((1S)-1-((1R)-2-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-hydroxyethyl)-3-buten-1-yl)acetamide;
′N-((1S)-1-((1S)-2-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-hydroxyethyl)-3-buten-1-yl)acetamide;
′N-((1S)-1-((1R)-2-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-hydroxyethyl)-4,4,4-trifluorobutyl)acetamide;
′N-((1S,3E)-1-((1R)-2-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-hydroxyethyl)-3-penten-1-yl)acetamide;
′N-((1S)-1-((1R)-2-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-hydroxyethyl)-2-propen-1-yl)acetamide;
′N-((1S)-1-((1R)-2-(((4′S)-6′-(2-fluoro-2-methylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-hydroxyethyl)-3-buten-1-yl)acetamide;
′N-((1S)-1-((1R)-2-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-hydroxyethyl)-3-hexyn-1-yl)acetamide;
′N-((1S,2R)-3-(((2S,4S)-6-chloro-8-(4-morpholinyl)-3,4,4′,5′-tetrahydrospiro[chromene-2,3′-furan]-4-yl)amino)-1-((3,5-difluorophenyl)methyl)-2-hydroxypropyl)acetamide;
N-((1S,2R)-3-(((2R,4S)-6-chloro-8-(4-morpholinyl)-3,4,4′,5′-tetrahydrospiro[chromene-2,3′-furan]-4-yl)amino)-1-((3,5-difluorophenyl)methyl)-2-hydroxypropyl)acetamide;
N-((1S,2R)-3-(((4S)-6-(2,2-dimethylpropyl)-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-2-(1H-2-methyl-imidazol-1-yl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-bromo-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((3,5-difluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-2-hydroxy-3-(((4′S)-6′-(1H-pyrazol-1-yl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)propyl)acetamide;
′N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-2-hydroxy-3-(((4′S)-6′-(1H-imidazol-1-yl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)propyl)acetamide;
′N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-2-hydroxy-3-(((4′S)-6′-(1,3-thiazol-2-yl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)propyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-c]pyridin]-4′-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
′N-((1S,2R)-1-((3-chloro-5-fluorophenyl)methyl)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-c]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((3-chloro-5-fluorophenyl)methyl)-2-hydroxy-3-(((4′S)-6′-(2-hydroxy-2-methylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-c]pyridin]-4′-yl)amino)propyl)acetamide;
′N-((1S,2R)-3-(((4′S)-8′-chloro-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-c]pyridin]-4′-yl)amino)-1-((3-chloro-5-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-8′-chloro-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-c]pyridin]-4′-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
′N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-3-(((5′S)-3′-(2,2-dimethylpropyl)-5′,6′-dihydrospiro[cyclobutane-1,7′-pyrano[2,3-c]pyridazin]-5′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-8′-(4-morpholinyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-c]pyridin]-4′-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-8′-(1-pyrrolidinyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-c]pyridin]-4′-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
′N-((1S,2R)-1-((3-(dimethylamino)-5-fluorophenyl)methyl)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((3-bromo-5-fluorophenyl)methyl)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydro spiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3-methyl-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
N-((1S,2R)-3-(((1s,3R,4′S)-6′-(2,2-dimethylpropyl)-3-methyl-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3-methyl-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-3-(((1s,3R,4′S)-6′-(2,2-dimethylpropyl)-3-methyl-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3-methyl-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((1s,3R,4′S)-6′-(2,2-dimethylpropyl)-3-methyl-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((2,3-difluorophenyl)methyl)-3-(((1r,3S,4′S)-6′-(2,2-dimethylpropyl)-3-methyl-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((2,3-difluorophenyl)methyl)-3-(((1s,3R,4′S)-6′-(2,2-dimethylpropyl)-3-methyl-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((1s,3R,4′S)-6′-(2,2-dimethylpropyl)-3-methyl-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((3-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((1s,3S,4′S)-6′-(2,2-dimethylpropyl)-3-hydroxy-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4S)-6-(cyclopentylamino)-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
′N-((1S,2R)-3-(((4S)-6-((1,1-dimethylethyl)amino)-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
′N-((1S,2R)-3-(((4S)-6-chloro-8-(1H-imidazol-1-yl)-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)-1-((3,5-difluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4S)-6-bromo-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)-1-((3,5-difluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4S)-8-(1H-benzimidazol-1-yl)-6-chloro-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)-1-((3,5-difluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4S)-6-chloro-8-(1H-pyrazol-1-yl)-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)-1-((3,5-difluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-2-hydroxy-3-(((4S)-6-(1H-pyrazol-1-yl)-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)propyl)acetamide;
′N-((1S,2R)-2-hydroxy-1-(phenylmethyl)-3-(((4S)-6-(2-thienyl)-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)propyl)acetamide;
′N-((1S,2R)-2-hydroxy-3-(((4S)-6-(1-(2-methylpropyl)-1H-pyrazol-3-yl)-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)-1-(phenylmethyl)propyl)acetamide;
′N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-2-hydroxy-3-(((4S)-6-(1-(2-methylpropyl)-1H-pyrazol-3-yl)-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)propyl)acetamide;
′N-((1S,2S)-1-((3,5-difluorophenyl)methyl)-2-hydroxy-3-(((4S)-6-(1H-pyrazol-1-yl)-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)propyl)acetamide;
′N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-2-hydroxy-3-(((4S)-6-(1H-imidazol-1-yl)-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)propyl)acetamide;
′N-((1S,2R)-2-hydroxy-3-(((4S)-6-(1-methyl-1H-pyrazol-3-yl)-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)-1-(phenylmethyl)propyl)acetamide;
′N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-2-hydroxy-3-(((4S)-6-(1-methyl-1H-pyrazol-3-yl)-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)propyl)acetamide;
′N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-2-hydroxy-3-(((4S)-6-(2-thienyl)-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)propyl)acetamide;
′N-((1S,2S)-3-(((4S)-6-chloro-8-(1H-pyrazol-1-yl)-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)-1-((3,5-difluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4S)-7-bromo-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)-1-((3,5-difluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-2-hydroxy-3-(((4S)-7-(1H-imidazol-1-yl)-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)propyl)acetamide;
′N-((4S)-4-(((2R,3S)-3-(acetylamino)-4-(3,5-difluorophenyl)-2-hydroxybutyl)amino)-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-6-yl)acetamide;
′N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-2-hydroxy-3-(((4S)-6-((3R)-tetrahydro-3-furanylamino)-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)propyl)acetamide;
′N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-2-hydroxy-3-(((4S)-6-(2H-1,2,3-triazol-2-yl)-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)propyl)acetamide;
′N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-2-hydroxy-3-(((4S)-6-(1H-1,2,4-triazol-1-yl)-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)propyl)acetamide;
′N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-2-hydroxy-3-(((4S)-6-(2-oxo-1-pyrrolidinyl)-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)propyl)acetamide;
′N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-2-hydroxy-3-(((4S)-6-(2-oxo-1-azetidinyl)-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)propyl)acetamide;
′N-((1S,2R)-3-(((4S)-6-bromo-7-fluoro-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)-1-((3,5-difluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-3-(((4S)-7-fluoro-6-((3R)-tetrahydro-3-furanylamino)-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-3-(((4S)-7-fluoro-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((3-fluoro-5-(tetrahydro-2H-pyran-4-ylamino)phenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-3-(((4S)-7-fluoro-6-(tetrahydro-2H-pyran-4-ylamino)-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((3-fluorophenyl)methyl)-3-(((4S)-7-fluoro-6-(1H-pyrazol-1-yl)-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((4-fluorophenyl)methyl)-3-(((4S)-7-fluoro-6-(1H-pyrazol-1-yl)-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-(cyclobutylmethyl)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1((2-bromophenyl)methyl)-3(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((3-chloro-5-fluorophenyl)methyl)-3-(((4′S)-6′-((1R)-1-fluoro-2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(1-azatricyclo[6.2.2.0˜2,7˜]dodeca-2,4,6-trien-8-ylamino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
′N-((1S,2R)-3-(((2R,4S)-1′-acetyl -6-ethyl-3,4-dihydrospiro[chromene-2,3′-pyrrolidin]-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
N-((1S,2R)-3-(((2S,4S)-1′-acetyl-6-ethyl-3 ,4-dihydrospiro[chromene-2,3′-pyrrolidin]-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxy-1-((2,4,6-trifluorophenyl)methyl)propyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxy-1-((2,3,4-trifluorophenyl)methyl)propyl)acetamide;
′N-((1S,2R)-2-hydroxy-3-(((4′S)-6′-(2-methylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((2,4,6-trifluorophenyl)methyl)propyl)acetamide;
′N-((1S,2R)-2-hydroxy-3-(((4′S)-6′-(2-methylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((2,3,4-trifluorophenyl)methyl)propyl)acetamide;
′N-((1S,2R)-1((4-chlorophenyl)methyl)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclopentane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((4-fluorophenyl)methyl)-2-hydroxy-3-(((4′S)-6′-(phenylmethyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)propyl)acetamide;
′N-((1S,2R)-2-hydroxy-1-(phenylmethyl)-3-(((4S)-6-((2R)-tetrahydro-2-furanyl)-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)propyl)acetamide;
N-((1S,2R)-2-hydroxy-1-(phenylmethyl)-3-(((4S)-6-((2S)-tetrahydro-2-furanyl)-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)propyl)acetamide;
′N-((1S,2R)-2-hydroxy-1-(phenylmethyl)-3-(((4′S)-6′-((2S)-tetrahydro-2-furanylmethyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)propyl)acetamide;
N-((1S,2R)-2-hydroxy-1-(phenylmethyl)-3-(((4′S)-6′-((2R)-tetrahydro-2-furanylmethyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)propyl)acetamide;
′N-((1S,2R)-2-hydroxy-1-(phenylmethyl)-3-(((4′S)-6′-((2R)-tetrahydro-2-furanylmethyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)propyl)-2-(methyloxy)acetamide;
N-((1S,2R)-2-hydroxy-1-(phenylmethyl)-3-(((4′S)-6′-((2S)-tetrahydro-2-furanylmethyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)propyl)-2-(methyloxy)acetamide;
′N-((1S,2R)-2-hydroxy-1-(phenylmethyl)-3-(((4S)-6-((2S)-tetrahydro-2-furanylmethyl)-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)propyl)acetamide;
N-((1S,2R)-2-hydroxy-1-(phenylmethyl)-3-(((4S)-6-((2R)-tetrahydro-2-furanylmethyl)-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)propyl)acetamide;
′N-((1S,2R)-2-hydroxy-3-(((4S)-6-(5-hydroxypentyl)-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)-1-(phenylmethyl)propyl)acetamide;
′N-((1S,2R)-2-hydroxy-3-(((4′S)-6′-(((2S)-2-methyltetrahydro-2-furanyl)methyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-(phenylmethyl)propyl)acetamide;
N-((1S,2R)-2-hydroxy-3-(((4′S)-6′-(((2R)-2-methyltetrahydro-2-furanyl)methyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-(phenylmethyl)propyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxy-1-(3-pyridinylmethyl)propyl)acetamide;
′N-((1S,2R)-1-((2,3-difluorophenyl)methyl)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((2,6-difluorophenyl)methyl)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2-fluoro-2-methylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-c]pyridin]-4′-yl)amino)-1-((3-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((4-chlorophenyl)methyl)-3-(((4′S)-6′-(2-fluoro-2-methylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxy-1-((1-methyl-3-piperidinyl)methyl)propyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((5-fluoro-3-pyridinyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2S)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((5-fluoro-3-pyridinyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((4-fluorophenyl)methyl)-2-hydroxy-3-(((4′S)-6′-((trimethylsilyl)methyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)propyl)acetamide;
′N-((1S,2R)-1-((3,4-bis(methyloxy)phenyl)methyl)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((3-fluorophenyl)methyl)-2-hydroxy-3-(((4′S)-6′-((trimethylsilyl)methyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)propyl)acetamide;
′N-((1S,2R)-1-((2,3-difluorophenyl)methyl)-2-hydroxy-3-(((4′S)-6′-((trimethylsilyl)methyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)propyl)acetamide;
′N-((1S,2R)-1-((2,3-difluorophenyl)methyl)-3-(((4′S)-6′-(2-fluoro-2-methylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((3-bromo-4-fluorophenyl)methyl)-3-(((4′S)-6′-(2-fluoro-2-methylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-3-(((4′S)-6′-(2-fluoro-2-methylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((3-chloro-4-fluorophenyl)methyl)-3-(((4′S)-6′-(2-fluoro-2-methylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((3-chloro-5-fluorophenyl)methyl)-3-(((4′S)-6′-(2-fluoro-2-methylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2-fluoro-2-methylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxy-1-((3-(trifluoromethyl)phenyl)methyl)propyl)acetamide;
′N-((1S,2R)-1-(1,3-benzodioxo1-5-ylmethyl)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-(1,3-benzodioxol-5-ylmethyl)-3-(((4′S)-6′-(2-fluoro-2-methylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-2-hydroxy-1-(phenylmethyl)-3-(((4S)-6-(2,2,2-trifluoroethyl)-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)propyl)acetamide;
′N-((1S,2R)-2-hydroxy-1-(phenylmethyl)-3-(((4S)-6-(2-pyridinyl)-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)propyl)acetamide;
′N-((1S,2R)-2-hydroxy-1-(phenylmethyl)-3-(((4′S)-6′-(2,2,2-trifluoroethyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)propyl)acetamide;
′N-((1S,2R)-1-((3,4-difluorophenyl)methyl)-2-hydroxy-3 -(((4′S)-6′-(2,2,2-trifluoroethyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)propyl)acetamide;
′N-((1S,2R)-1-((3-fluorophenyl)methyl)-2-hydroxy-3-(((4′S)-6′-(2,2,2-trifluoroethyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)propyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-bromo-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((3-fluorophenyl)methyl)-2-hydroxy-3-(((4′S)-6′-(2-methylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)propyl)acetamide;
′N-((1S,2R)-1-((4-fluorophenyl)methyl)-2-hydroxy-3-(((4′S)-6′-(2-methylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)propyl)acetamide;
′N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-2-hydroxy-3-(((4′S)-6′-(2-methylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)propyl)acetamide;
′N-((1S,2R)-1-((3-chloro-5-fluorophenyl)methyl)-2-hydroxy-3-(((4′S)-6′-(2-methylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)propyl)acetamide;
′3-((2S,3R)-2-(acetylamino)-3-hydroxy-4-(((4′S)-6′-(2-methylpropyl-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)butyl)benzamide;
′N-((1S,2R)-1-((3-cyanophenyl)methyl)-2-hydroxy-3-(((4′S)-6′-(2-methylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)propyl)acetamide;
′N-((1S,2R)-1((2,3-difluorophenyl)methyl)-2-hydroxy-3-(((4′S)-6′-(2-methylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)propyl)acetamide;
′N-((1S,2R)-1-((3,4-difluorophenyl)methyl)-2-hydroxy-3-(((4′S)-6′-(2-methylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)propyl)acetamide;
′N-((1S,2R)-3-(((4′S)-7′-fluoro-6′-(2-methylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
′N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-3-(((4′S)-7′-fluoro-6′-(2-methylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-7′-fluoro-6′-(2-methylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-7′-fluoro-6′-(2-methylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-1-((3-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((2,3-difluorophenyl)methyl)-3-(((4′S)-7′-fluoro-6′-(2-methylpropy1)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((4-chloro-3-fluorophenyl)methyl)-2-hydroxy-3-(((4′S)-6′-(2-methylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)propyl)acetamide;
′N-((1S,2R)-1-((4-chlorophenyl)methyl)-2-hydroxy-3-(((4′S)-6′-(2-methylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)propyl)acetamide;
′N-((1S,2R)-1-((4-fluorophenyl)methyl)-2-hydroxy-3-(((4′S)-6′-(1,3,3,3-tetrafluoro-2-methylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)propyl)acetamide;
′N-((1S,2R)-1-((4-chlorophenyl)methyl)-2-hydroxy-3-(((4′S)-6′-(1,3,3,3-tetrafluoro-2-methylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)propyl)acetamide;
′N-((1S,2R)-1-((3-fluorophenyl)methyl)-2-hydroxy-3-(((4′S)-6′-(1,3,3,3-tetrafluoro-2-methylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)propyl)acetamide;
′N-((1S,2R)-2-hydroxy-1-(phenylmethyl)-3-(((4′S)-6′-(1,3,3,3-tetrafluoro-2-methylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)propyl)acetamide;
′N-((1S,2R)-1-((3-fluorophenyl)methyl)-2-hydroxy-3-(((4′S)-6′-(3,3,3-trifluoro-1-hydroxy-2-methylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)propyl)acetamide;
′N-((1S,2R)-1-((4-chlorophenyl)methyl)-2-hydroxy-3-(((4′S)-6′-(3,3,3-trifluoro-1-hydroxy-2-methylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)propyl)acetamide;
′N-((1S,2R)-2-hydroxy-1-(phenylmethyl)-3(((4′S)-6′-(3,3,3-trifluoro-1-hydroxy-2-methylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)propyl)acetamide;
′N-((1S,2R)-1-((3-fluorophenyl)methyl)-2-hydroxy-3-(((4′S)-6′-((2R)-3,3,3-trifluoro-2-methylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)propyl)acetamide;
N-((1S,2R)-1-((3-fluorophenyl)methyl)-2-hydroxy-3-(((4′S)-6′-((2S)-3,3,3-trifluoro-2-methylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)propyl)acetamide;
′ethyl 1-(2-(((1S,2R)-3-(((4S)-6-bromo-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)amino)-2-oxoethyl)-1H-1,2,3-triazole-4-carboxylate;
′N-((1S,2R)-1-((3-bromo-4-fluorophenyl)methyl)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′2-(5-(aminomethyl)-1H-1,2,3-triazol-1-yl)-N-((1S,2R)-3-(((4S)-6-bromo-3,4-dihydrospiro[chromene-2,1′-cyclobutan]-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
′N-((1R,2R)-1-((3-chloro-2-fluorophenyl)methyl)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((5-chloro-2-fluorophenyl)methyl)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((3-chloro-2-fluorophenyl)methyl)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((3-chloro-2,4-difluorophenyl)methyl)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((3-chloro-4,5-difluorophenyl)methyl)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxy-1-((2,3,6-trifluorophenyl)methyl)propyl)acetamide;
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxy-1-((2,3,5-trifluorophenyl)methyl)propyl)acetamide;
′N-((1S,2R)-1((4-bromophenyl)methyl)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′N-((1S,2R)-1-((4-chlorophenyl)methyl)-2-hydroxy-3-(((4′S)-6′-((1-methylethyl)oxy)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)propyl)acetamide;
′methyl ((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)carbamate;
′N-((1S,2R)-1((3,5-difluorophenyl)methyl)-3-(((4′S)-6′-ethyl-3′,4′-dihydro spiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)acetamide;
′methyl ((1S,2R)-1-((3,5-difluorophenyl)methyl)-3-(((4′S)-6′-ethyl-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)carbamate;
′methyl ((1S,2R)-1-((3,5-difluorophenyl)methyl)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)-2-hydroxypropyl)carbamate; and
′N-((1S,2R)-3-(((4′S)-6′-(2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-c]pyridin]-4′-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)propanamide; and
′N-((1S,2R)-1-((4-fluorophenyl)methyl)-2-hydroxy-3-(((4′S)-6′-(3-hydroxy-2,2-dimethylpropyl)-3′,4′-dihydrospiro[cyclobutane-1,2′-pyrano[2,3-b]pyridin]-4′-yl)amino)propyl)acetamide.

### Claim 11 (depends on 1)

A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound according to claim 1.

### Claim 12 (depends on 8)

A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound according to claim 8.

### Claim 13 (depends on 1)

A method of treating Alzheimer's disease in a subject, the method comprising administering to the subject an effective dosage amount of a compound according to claim 1.

### Claim 14 (depends on 8)

A method of treating Alzheimer's disease in a subject, the method comprising administering to the subject an effective dosage amount of a compound according to claim 8.

### Claim 15 (depends on 1)

A method of making a compound of claim 1, the method comprising the step of
reacting a compound 20
wherein i, j, A, B, R3, R4 and R5 are as defined in claim 1, with a compound having the structure A-W-X, wherein A and W are as defined in claim 1 and X is a leaving group, to make a compound of claim 1.