# US 7,745,482 B2 · Alpha crystalline form of strontium ranelate

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- Number: US 7,745,482 B2
- Document ID: US7745482B2
- Status: Granted
- Kind: B2
- Application number: 12/228,381
- Filed: 2008-08-12
- Published: 2008-12-18
- Granted: 2010-06-29
- Earliest claimed: 2004-09-30
- Assignees: Les Laboratoires Servier
- Inventors: Stephane Horvath; Isabelle Demuynck; Gerard Damien
- Web page: https://patentgrep.com/patent/US7745482B2

## CPC

- C07D 333/38: Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- A61P 19/00: Drugs for skeletal disorders
- A61P 19/02: for joint disorders, e.g. arthritis, arthrosis
- A61P 19/10: for osteoporosis
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Alpha crystalline form of strontium ranelate of formula (I): characterised by its powder X-ray diffraction diagram and by a water content of from 22 to 24%. Medicinal products containing the same which are useful in the treatment of osteoporosis and arthrosis.

## Claims

### Claim 1

An alpha crystalline form of strontium ranelate of formula (I):

### Claim 2 (depends on 1)

The alpha crystalline form of strontium ranelate of claim 1 having a powder X-ray diffraction diagram exhibiting peaks at 7.6, 8.0, 8.6, 11.3, 12.0 and 13.5 deg 2 theta.

### Claim 3 (depends on 1)

A pharmaceutical composition comprising as active ingredient the alpha crystalline form of strontium ranelate of claim 1 in combination with one or more pharmaceutically acceptable, inert and non-toxic carriers.

### Claim 4 (depends on 1)

A method of treating a living animal body afflicted with osteoporosis, comprising the step of administering to the living animal body an amount of a compound of claim 1 which is effective for alleviation of the condition.

### Claim 5 (depends on 1)

A method of treating a living animal body afflicted with arthrosis, comprising the step of administering to the living animal body an amount of a compound of claim 1 which is effective for alleviation of the condition.