# US 7,745,472 B2 · Compound > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 7,745,472 B2 - Document ID: US7745472B2 - Status: Granted - Kind: B2 - Application number: 12/056,920 - Filed: 2008-03-27 - Published: 2009-04-30 - Granted: 2010-06-29 - Earliest claimed: 2001-11-21 - Assignees: Sterix Limited - Inventors: Barry Victor Lloyd Potter; Lok Wai Lawrence Woo; Atul Purohit; Michael John Reed; Oliver Brook Sutcliffe; Christian Bubert - Web page: https://patentgrep.com/patent/US7745472B2 ## CPC - C07D 249/08: 1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles - A61P 35/00: Antineoplastic agents - A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 - C07D 231/12: with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms - C07D 233/56: with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms - C07D 413/12: linked by a chain containing hetero atoms as chain links - C07D 417/12: linked by a chain containing hetero atoms as chain links - C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS ## Abstract There is provided a compound of Formula I wherein each T is independently selected from H, hydrocarbyl, —F—R, and a bond with one of D, E, P or Q, or together with one of P and Q forms a ring; Z is a suitable atom the valency of which is m; D, E and F are each independently of each other an optional linker group, wherein when Z is nitrogen E is other than CH2 and C═O; P, Q and R are independently of each other a ring system; and at least Q comprises a sulphamate group. ## Claims ### Claim 1 A method of treatment for use in the therapy of breast cancer, prostate cancer, ovarian cancer or endometrial cancer comprising administration of a pharmaceutical composition comprising a compound of Formula IIId wherein i) E is an optional linker group; R is a 5-, 6- or 7-membered carbocyclic ring; P is an optionally substituted 5- or 6-membered heterocyclic ring containing 1 to 3 hetero atoms selected from the group consisting of N, O and S; Q is a polycyclic ring system: at least Q comprises a sulphamate group; and at least one of P, Q and R is optionally substituted by one or more halo atoms or ii) E is an optional linker group; R is a 5-, 6- or 7-membered carbocyclic P is an optionally substituted 5- or 6-membered heterocyclic ring containing 1 to 3 hetero atoms selected from the group consisting of N, O and S; Q is a 5-, 6- or 7-membered ring: at least Q comprises a sulphamate group; and at least one of P, Q and R is substituted by one or more halo atoms. ### Claim 2 (depends on 1) A method according to claim 1 wherein: E is an optional linker group; R is a 5-, 6- or 7-membered carbocyclic ring; P is 4H-1,2,4-triazole; Q is a polycyclic ring system: at least Q comprises a sulphamate group. ### Claim 3 (depends on 1) A method according to claim 1 wherein P is 4H-1,2,4-triazole and Q and R are independently selected from or comprise carbocyclic ring systems selected from the group consisting of aryl groups, cycloalkyl groups, substituted and unsubstituted aromatic rings, and substituted and unsubstituted benzyl rings. ### Claim 4 (depends on 1) A method according to claim 1 wherein P is an imidazole, tetrazole or pyrazole. ### Claim 5 (depends on 1) A method according to claim 1 wherein P is an optionally substituted 5- or 6- membered heterocyclic ring containing 1 to 3 hetero atoms selected from the group consisting of N, O and S; Q is a 5-, 6- or 7-membered carbocyclic ring; and at least one of P, Q and R is substituted by one or more halo atoms. ### Claim 6 (depends on 1) A method according to claim 1 wherein E is other than CH2 and C═O. ### Claim 7 (depends on 1) A method according to claim 1 wherein Q is substituted by a halogen. ### Claim 8 (depends on 1) A method according to claim 1 wherein the optional linker group is present. ### Claim 9 (depends on 1) A method according to claim 1, wherein the optional linker group is independently selected from C═O and hydrocarbyl groups. ### Claim 10 (depends on 1) A method according to claim 1, wherein the optional linker group is independently selected from C═O and straight or branched hydrocarbon groups containing at least one hetero atom in the group. ### Claim 11 (depends on 1) A method according to claim 1, wherein the optional linker group is selected from C═O and hydrocarbon groups and a group of the formula wherein n is 1 to 6 and Y═Oxygen, Sulphur or CH2. ### Claim 12 (depends on 1) A method according to claim 1, wherein the optional linker group is independently selected from C═O and linear or branched hydrocarbon groups having a carbon chain of from 1 to 6 carbon atoms and a group of the formula wherein n is 1 to 6 and Y═Oxygen, Sulphur or CH2. ### Claim 13 (depends on 1) A method according to claim 1, wherein E is selected from straight or branched hydrocarbon groups containing at least one hetero atom in the group. ### Claim 14 (depends on 1) A method according to claim 1, wherein E is selected from hydrocarbon groups comprising at least 2 carbons and a group of the formula wherein n is 1 to 6 and Y═Oxygen, Sulphur or CH2. ### Claim 15 (depends on 1) A method according to claim 1, wherein E is selected from linear or branched hydrocarbon groups having a carbon chain of from 2 to 6 carbon atoms and a group of the formula wherein n is 1 to 6 and Y═Oxygen, Sulphur or CH2. ### Claim 16 (depends on 1) A method according to claim 1, wherein Q and R are independently selected from or comprise an aromatic ring. ### Claim 17 (depends on 1) A method according to claim 1, wherein Q and R are independently selected from substituted and unsubstituted aromatic rings. ### Claim 18 (depends on 1) A method according to claim 1 wherein P is 4H-1,2,4-triazole and Q and R are independently selected from substituted or unsubstituted 6-membered carbocyclic aromatic rings. ### Claim 19 (depends on 1) A method according to claim 1 wherein E is a straight chain or branched hydrocarbon group, and P is an imidazole, tetrazole, pyrazole or triazole. ### Claim 20 (depends on 19) A method according to claim 19 wherein E is a C1-C10 hydrocarbon group containing at least two carbons or at least one hetero atom in the group. ### Claim 21 (depends on 1) A method according to claim 1 wherein the compound is selected from compounds of the formulae ### Claim 22 (depends on 19) A method according to claim 19 wherein P is 1H-1,2,3- triazole, 1H-1,2,4-triazole or 4H-1,2,4-triazole. ### Claim 23 (depends on 19) A method according to claim 19 wherein the halo atom is bromine. ### Claim 24 (depends on 19) A method according to claim 19 wherein R is a substituted 6-membered carbocyclic aromatic ring. ### Claim 25 (depends on 19) A method according to claim 19 wherein R is ### Claim 26 (depends on 19) A method according to claim 19 wherein the sulphamate group is H2NO2SO—. ### Claim 27 (depends on 19) A method according to claim 19 wherein Q is an unsubstituted or substituted 6-membered carbocyclic aromaticbenzyl ring and the halo atom is ortho to the sulphamate group.