# US 7,745,463 B2 · Alkene piperidine derivatives as antiviral agents

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- Number: US 7,745,463 B2
- Document ID: US7745463B2
- Status: Granted
- Kind: B2
- Application number: 12/484,407
- Filed: 2009-06-15
- Published: 2009-10-08
- Granted: 2010-06-29
- Earliest claimed: 2006-06-08
- Assignees: Bristol-Myers Squibb Company
- Inventors: Tao Wang; Ying Han; John F. Kadow; Zhongxing Zhang; Nicholas A. Meanwell
- Web page: https://patentgrep.com/patent/US7745463B2

## CPC

- A61K 31/445: Non condensed piperidines, e.g. piperocaine
- A61K 31/4545: containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61P 31/12: Antivirals
- A61P 31/18: for HIV
- C07D 211/70: with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D 401/06: linked by a carbon chain containing only aliphatic carbon atoms
- C07D 401/12: linked by a chain containing hetero atoms as chain links
- C07D 401/14: containing three or more hetero rings
- C07D 413/06: linked by a carbon chain containing only aliphatic carbon atoms
- C07D 413/14: containing three or more hetero rings
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)

## Abstract

This disclosure provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the disclosure is concerned with alkene piperidine derivatives that possess unique antiviral activity. More particularly, the present disclosure relates to compounds useful for the treatment of HIV and AIDS.

## Claims

### Claim 1

A compound defined by the following formula, or pharmaceutically acceptable salts thereof:

### Claim 2 (depends on 1)

A pharmaceutical composition which comprises an antiviral effective amount of the compound, or pharmaceutically acceptable salts thereof, as claimed in claim 1, and one or more pharmaceutically acceptable carriers, excipients or diluents.

### Claim 3 (depends on 2)

The composition of claim 2 further comprising a second compound having anti-HIV activity.

### Claim 4 (depends on 2)

The pharmaceutical composition of claim 2, useful for treating infection by HIV, which additionally comprises an antiviral effective amount of an AIDS treatment agent selected from the group consisting of:
(a) an AIDS antiviral agent;
(b) an anti-infective agent;
(c) an immunomodulator; and
(d) HIV entry inhibitors.