# US 7,745,448 B2 · Crystalline N-(4-(4-aminothieno[2,3-d]pyrimidin-5-yl)phenyl)-N′-(2-fluoro-5-(trifluoromethyl)phenyl)urea ethanolate

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- Number: US 7,745,448 B2
- Document ID: US7745448B2
- Status: Granted
- Kind: B2
- Application number: 11/642,395
- Filed: 2006-12-20
- Published: 2007-07-05
- Granted: 2010-06-29
- Earliest claimed: 2005-12-28
- Assignees: Abbott Laboratories
- Inventors: Sean M. Mellican; Cathie L. Linton; Jianzhang Mei; Jason S. Tedrow; Nahathai Charukamnoetkanok; Rodger Henry
- Web page: https://patentgrep.com/patent/US7745448B2

## CPC

- C07D 495/04: Ortho-condensed systems
- A61P 9/12: Antihypertensives
- A61P 17/06: Antipsoriatics
- A61P 35/02: specific for leukemia
- A61P 35/04: specific for metastasis
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

A crystalline N-(4-(4-aminothieno[2,3 -d]pyrimidin-5-yl)phenyl)-N′-(2-fluoro-5-(trifluoromethyl)phenyl)urea ethanolate characterized in the monoclinic crystal system and P21/n space group, when measured with radiation at 0.7107 Å, by lattice parameters a, b and c of 5.0318 ű0.006 Å, 23.684 ű0.002 Å and 18.877 ű0.002 Å, respectively, and β of 90.703±0.003, ways to make it, compositions comprising it, and methods of treatment using it are disclosed.

## Claims

### Claim 1

Crystalline N-(4-(4-aminothieno[2,3-d]pyrimidin-5-yl)phenyl)-N′-(2-fluoro-5-(trifluoromethyl)phenyl)urea ethanolate characterized in the monoclinic crystal system and P21/n space group, when measured with radiation at 0.7107 Å, by lattice parameters a, b and c of 5.0318 ű0.006Å, 23.684 ű0.002 Å and 18.877 ű0.002 Å, respectively, and β of 90.703±0.003.

### Claim 2

Crystalline N-(4-(4-aminothieno[2,3-d]pyrimidin-5-yl)phenyl)-N′-(2-fluoro-5-(trifluoromethyl)phenyl)urea ethanolate having substantial crystalline purity and characterized in the monoclinic crystal system and P21/n space group, when measured with radiation at 0.7107 Å, by lattice parameters a, b and c of 5.0318 ű0.006 Å, 23.684 ű0.002 Å and 18.877 ű0.002 Å, respectively, and β of 90.703±0.003.