# US 7,745,425 B2 · Non-irritating compositions containing zinc salts > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 7,745,425 B2 - Document ID: US7745425B2 - Status: Granted - Kind: B2 - Application number: 11/327,677 - Filed: 2006-01-06 - Published: 2007-01-25 - Granted: 2010-06-29 - Earliest claimed: 2003-02-07 - Assignees: The Trustees of Columbia University in the City of New York - Inventors: Shanta M. Modak; Milind S. Shintre; Lauserpina Caraos; Trupti Gaonkar; Ingrid Geraldo - Web page: https://patentgrep.com/patent/US7745425B2 ## CPC - A61K 8/27: Zinc; Compounds thereof - A61K 8/36: Carboxylic acids; Salts or anhydrides thereof - A61K 8/361: {Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof} - A61K 8/365: Hydroxycarboxylic acids; Ketocarboxylic acids - A61K 8/368: with carboxyl groups directly bound to carbon atoms of aromatic rings - A61K 8/42: Amides - A61K 31/195: having an amino group - A61K 33/30: Zinc; Compounds thereof - A61Q 17/005: {Antimicrobial preparations} - A61Q 19/00: Preparations for care of the skin - A61K 2800/75: Anti-irritant - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS ## Abstract The present invention relates to methods and compositions which employ low concentrations of combinations of zinc salts to prevent the irritation of skin or mucous membranes that may be caused by therapeutic agents, by personal hygiene products, by articles such as gloves or condoms, or by various physical, chemical, mechanical, or biological irritants. ## Claims ### Claim 1 A coating for application to an article, comprising: two water soluble zinc salts, each at a concentration of between 0.1 and 1 weight percent; a first water insoluble zinc salt at a concentration of between about 0.1 and 1 weight percent; panthenol at a concentration of between about 0.05 and 5 weight percent; and glycerin, at a concentration between about 0 and 5 weight percent. ### Claim 2 (depends on 1) The coating according to claim 1, further comprising a third water soluble zinc salt at a concentration of between 0.1 and 1 weight percent. ### Claim 3 (depends on 1, 2) The coating according to claim 1 or 2, wherein the combined amounts of all water soluble zinc salts is between about 0.1 and 0.5 weight percent. ### Claim 4 (depends on 1, 2) The coating according to claim 1 or 2, where the water soluble zinc salts are selected from the group consisting of zinc acetate, zinc butyrate, zinc gluconate, zinc glycerate, zinc glycolate, zinc formate, zinc lactate, zinc picolinate, zinc priopionate, zinc salicylate, zinc tartrate, and zinc undecylenate. ### Claim 5 (depends on 3) The coating according to claim 3, where the water soluble zinc salts are selected from the group consisting of zinc acetate, zinc butyrate, zinc glycerate, zinc gluconate, zinc glycolate, zinc formate, zinc lactate, zinc picolinate, zinc priopionate, zinc salicylate, zinc tartrate and zinc undecylenate. ### Claim 6 (depends on 1, 2, 3, 4) The coating according to claim 1, 2, 3 or 4, further comprising a second water insoluble zinc salt. ### Claim 7 (depends on 6) The coating according to claim 6, wherein the first or second water insoluble zinc salt is selected from the group consisting of zinc oxide, zinc stearate, zinc phosphate, zinc carbonate, zinc borate and zinc citrate. ### Claim 8 A coating for application to an article, comprising: two water soluble zinc salts, each at a concentration of between 0.1 and 1 weight percent; panthenol at a concentration of between about 0.05 and 5 weight percent; and an effective amount of an antimicrobial agent. ### Claim 9 (depends on 8) The coating of claim 8, where the antimicrobial agent is selected from the group consisting of biguanides, iodophors, quaternary ammonium compounds, phenoxyethanol, phenylethyl alcohol, 2,4-dichlorobenzyl alcohol, thiomersal, clindamycin, erythromycin, benzoyl peroxide, mupirocin, bacitracin, polymyxin B, neomycin, triclosan, parachlorometaxylenol, foscarnet, miconazole, fluconzaole, itriconazole and ketoconazole. ### Claim 10 (depends on 8) The coating according to claim 8, further comprising a third water soluble zinc salt at a concentration of between 0.1 and 1 weight percent. ### Claim 11 (depends on 8, 9) The coating according to claim 8, 9, or 10, wherein the combined amounts of all water soluble zinc salts is between about 0.1 and 0.5 weight percent. ### Claim 12 (depends on 8, 9, 10) The coating according to claim 8, 9 or 10 where the water soluble zinc salts are selected from the group consisting of zinc acetate, zinc butyrate, zinc glycerate, zinc gluconate, zinc glycolate, zinc formate, zinc lactate, zinc picolinate, zinc priopionate, zinc salicylate, zinc tartrate and zinc undecylenate. ### Claim 13 (depends on 11) The coating according to claim 11, where the water soluble zinc salts are selected from the group consisting of zinc acetate, zinc butyrate, zinc glycerate, zinc gluconate, zinc glycolate, zinc formate, zinc lactate, zinc picolinate, zinc priopionate, zinc salicylate, zinc tartrate and zinc undecylenate. ### Claim 14 (depends on 8) The coating according to claim 8, further comprising a water insoluble zinc salt. ### Claim 15 (depends on 14) The coating according to claim 14, wherein the water insoluble zinc salt is selected from the group consisting of zinc oxide, zinc citrate, zinc phosphate, zinc carbonate, zinc borate and zinc stearate. ### Claim 16 (depends on 1, 2) The coating of claim 1 or 2, further comprising an emollient solvent at a concentration of less than 5 weight percent. ### Claim 17 (depends on 6) The coating of claim 6, further comprising an emollient solvent at a concentration of less than 5 weight percent. ### Claim 18 (depends on 7) The coating of claim 7, further comprising an emollient solvent at a concentration of less than 5 weight percent. ### Claim 19 (depends on 8) The coating of claim 8, further comprising an emollient solvent at a concentration of less than 5 weight percent. ### Claim 20 (depends on 9) The coating of claim 9, further comprising an emollient solvent at a concentration of less than 5 weight percent. ### Claim 21 (depends on 10) The coating of claim 10, further comprising an emollient solvent at a concentration of less than 5 weight percent. ### Claim 22 (depends on 11) The coating of claim 11, further comprising an emollient solvent at a concentration of less than 5 weight percent. ### Claim 23 (depends on 12) The coating of claim 12, further comprising an emollient solvent at a concentration of less than 5 weight percent. ### Claim 24 (depends on 13) The coating of claim 13, further comprising an emollient solvent at a concentration of less than 5 weight percent. ### Claim 25 (depends on 14) The coating of claim 14, further comprising an emollient solvent at a concentration of less than 5 weight percent. ### Claim 26 (depends on 15) The coating of claim 15, further comprising an emollient solvent at a concentration of less than 5 weight percent. ### Claim 27 (depends on 1) An article having a surface to which a coating according to claim 1 has been applied. ### Claim 28 (depends on 2) An article having a surface to which a coating according to claim 2 has been applied. ### Claim 29 (depends on 3) An article having a surface to which a coating according to claim 3 has been applied. ### Claim 30 (depends on 4) An article having a surface to which a coating according to claim 4 has been applied. ### Claim 31 (depends on 5) An article having a surface to which a coating according to claim 5 has been applied. ### Claim 32 (depends on 6) An article having a surface to which a coating according to claim 6 has been applied. ### Claim 33 (depends on 7) An article having a surface to which a coating according to claim 7 has been applied. ### Claim 34 (depends on 8) An article having a surface to which a coating according to claim 8 has been applied. ### Claim 35 (depends on 9) An article having a surface to which a coating according to claim 9 has been applied. ### Claim 36 (depends on 10) An article having a surface to which a coating according to claim 10 has been applied. ### Claim 37 (depends on 11) An article having a surface to which a coating according to claim 11 has been applied. ### Claim 38 (depends on 12) An article having a surface to which a coating according to claim 12 has been applied. ### Claim 39 (depends on 13) An article having a surface to which a coating according to claim 13 has been applied. ### Claim 40 (depends on 14) An article having a surface to which a coating according to claim 14 has been applied. ### Claim 41 (depends on 15) An article having a surface to which a coating according to claim 15 has been applied. ### Claim 42 (depends on 16) An article having a surface to which a coating according to claim 16 has been applied. ### Claim 43 (depends on 17) An article having a surface to which a coating according to claim 17 has been applied. ### Claim 44 (depends on 18) An article having a surface to which a coating according to claim 18 has been applied. ### Claim 45 (depends on 19) An article having a surface to which a coating according to claim 19 has been applied. ### Claim 46 (depends on 20) An article having a surface to which a coating according to claim 20 has been applied. ### Claim 47 (depends on 21) An article having a surface to which a coating according to claim 21 has been applied. ### Claim 48 (depends on 22) An article having a surface to which a coating according to claim 22 has been applied. ### Claim 49 (depends on 23) An article having a surface to which a coating according to claim 23 has been applied. ### Claim 50 (depends on 24) An article having a surface to which a coating according to claim 24 has been applied. ### Claim 51 (depends on 25) An article having a surface to which a coating according to claim 25 has been applied. ### Claim 52 (depends on 26) An article having a surface to which a coating according to claim 26 has been applied. ### Claim 53 A surgical hand wash, comprising: (i) two or more water soluble zinc salts wherein said zinc salts in total are present at a combined concentration of between about 0.1 and 0.5 percent (weight/weight); (ii) farnesol at a concentration of between about 0.3 and 1.0 percent (weight/weight); (iii) panthenol at a concentration of between about 0.2 and 5 percent (weight/weight); and (iv) a quaternary ammonium compound and a biguanide, wherein the total concentration of quaternary ammonium compound and biguainde is between about 0.05 and 2.0 percent (weight/weight). ### Claim 54 (depends on 53) The surgical hand wash of claim 53, wherein the zinc salts are zinc gluconate, present at a concentration of between about 0.10-0.25 percent (weight/weight) and zinc lactate, present at a concentration of about between about 0.10-0.25 percent (weight/weight). ### Claim 55 A disinfectant soap, comprising: (i) two or more water soluble zinc salts, wherein said zinc salts in total are present at a combined concentration of between about 0.1 and 0.5 percent (weight/weight); (ii) farnesol at a concentration of between about 0.3 and 1.0 percent (weight/weight); (iii) panthenol at a concentration of between about 0.2 and 5 percent (weight/weight); and (iv) a quaternary ammonium compound and a second antimicrobial agent selected from the group consisting of a biguanide and a chlorinated phenol, wherein the total concentration of quaternary ammonium compound and second antimicrobial agent is between about 0.05 and 2.0 percent (weight/weight). ### Claim 56 (depends on 55) The disinfectant soap of claim 55, wherein the zinc salts are zinc gluconate, present at a concentration of between about 0.10-0.25 percent (weight/weight) and zinc lactate, present at a concentration of about between about 0.10-0.25 percent (weight/weight). ### Claim 57 (depends on 55) The disinfectant soap of claim 55, further comprising phenoxyethanol at a concentration of between about 0.3 and 1 percent (weight/weight). ### Claim 58 (depends on 56) The disinfectant soap of claim 56, further comprising phenoxyethanol at a concentration of between about 0.3 and 1 percent (weight/weight). ### Claim 59 A composition comprising: at least one water soluble zinc salt at a concentration of between about 0.05 and 2.0% w/w; D,L panthenol at a concentration between about 0.05 and 5.0% w/w; and a gelling agent at a concentration of between about 0.05 and 0.3% w/w; where the composition provides an anti-irritant effect. ### Claim 60 (depends on 59) The composition of claim 59, further comprising hydroxylalkyl cellulose at a concentration of less than about 0.3% w/w. ### Claim 61 (depends on 59) The composition of claim 59, further comprising polyethylene oxide at a concentration of less than about 0.3% w/w. ### Claim 62 (depends on 60) The composition of claim 60, further comprising polyethylene oxide at a concentration of less than about 0.3% w/w. ### Claim 63 (depends on 59) The composition of claim 59, further comprising a cellulose acetate polymer at a concentration of less than about 0.3% w/w. ### Claim 64 (depends on 60) The composition of claim 60, further comprising a cellulose acetate polymer at a concentration of less than about 0.3% w/w. ### Claim 65 (depends on 61) The composition of claim 61, further comprising a cellulose acetate polymer at a concentration of less than about 0.3% w/w. ### Claim 66 (depends on 62) The composition of claim 62, further comprising a cellulose acetate polymer at a concentration of less than about 0.3% w/w. ### Claim 67 (depends on 59) An article having a surface to which a coating according to claim 59 has been applied.