Methods and compositions for expanding T regulatory cells
AssigneeUniversity of Louisville Research Foundation, Inc.
InventorHaval Shirwan
Life of this patent
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Abstract
The present invention provides methods and compositions for expanding Treg cells ex vivo or in vivo using one or more conjugates comprising a costimulatory moiety that stimulates at least one of three signals involved in Treg cell development and/or using dendritic cells pulsed with antigens and modified to display TGF-β, or hematopoetic stem cells or bone marrow cells modified to display TGF-β. The methods and compositions are useful, for example, in the treatment and prevention of autoimmune disease, including Type 1 diabetes and in preventing foreign graft rejection, as well as to establish mixed chimerism, induce tolerance to autoantigens, alloantigens or xenoantigens, beta cell regeneration, prevention of foreign graft rejection, and treatment of a genetically inherited hematopoietic disorder.
Claims9
A method of expanding Treg cells in a patient comprising administering to said patient a composition comprising cells displaying 4-1BBL, wherein said cells are hematopoietic stem cells, bone marrow cells, or dendritic cells;
- and wherein said cells displaying 4-1BBL comprise biotin bound to a fusion protein comprising 4-1BBL and avidin, streptavidin, or core streptavidin.
Dependencies are inferred from the claim text.