# US 7,744,935 B2 · Compositions and methods for inhibiting 5-α reductase

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- Number: US 7,744,935 B2
- Document ID: US7744935B2
- Status: Granted
- Kind: B2
- Application number: 11/941,677
- Filed: 2007-11-16
- Published: 2008-10-02
- Granted: 2010-06-29
- Earliest claimed: 2003-09-16
- Inventors: Trevor P. Castor
- Web page: https://patentgrep.com/patent/US7744935B2

## CPC

- A61K 31/56: Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K 8/9794: Liliopsida [monocotyledons]
- A61K 36/889: Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
- A61P 17/14: for baldness or alopecia
- A61Q 5/008: {Preparations for oily hair}
- A61Q 7/00: Preparations for affecting hair growth
- A61Q 7/02: Preparations for inhibiting or slowing hair growth
- A61Q 19/00: Preparations for care of the skin
- A61K 2800/782: Enzyme inhibitors; Enzyme antagonists
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

Disclosed herein are compositions for controlling androgen activity in target organs and cells through the modulation of a 5-α-reductase activity. In certain aspects, these compositions are employed to modulate androgenic activity by inhibiting the formation and availability of active androgen in target cells. As a result, the present invention is directed toward the treatment of a wide variety of conditions including, but not limited to, the treatment of prostatic hyperplasia, prostatic cancer, hirsutism, acne, male pattern baldness, seborrhea, and other diseases related to androgen hyperactivity. Several of these compositions have been shown to effectively decrease body weight, and in some cases, to decrease the weight of an androgen-dependent body organ, such as the prostate and other organs.

## Claims

### Claim 1

A method of preparing a 5-α-reductase inhibitor preparation, comprising the following steps:
(a) grinding Saw Palmetto berries into a 100-mesh powder;
(b) extracting said powder with carbon dioxide at 1,000 psig and 22° C.;
(c) passing said carbon dioxide extract at 1,000 psig and 22° C. through an in-line C18 column; and
(d) collecting a 5-α reductase inhibitor preparation.