# US 7,744,930 B2 · Compositions, methods and kits for enhancing weight loss while inhibiting loss of lean body mass

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- Number: US 7,744,930 B2
- Document ID: US7744930B2
- Status: Granted
- Kind: B2
- Application number: 11/452,004
- Filed: 2006-06-12
- Published: 2006-12-07
- Granted: 2010-06-29
- Earliest claimed: 2002-11-22
- Assignees: Shaklee Corporation
- Inventors: Laurel Fisher; Jamie McManus; Kathleen Taylor; Haruna Yamaguchi
- Web page: https://patentgrep.com/patent/US7744930B2

## CPC

- A23L 2/52: Adding ingredients (adding preservatives A23B70/10)
- A23L 33/16: Inorganic salts, minerals or trace elements
- A23L 33/175: Amino acids
- A23L 33/185: Vegetable proteins
- A23L 33/40: {Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula}
- A61K 31/198: Alpha-amino acids, e.g. alanine or edetic acid [EDTA] (betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00)
- A61K 33/00: Medicinal preparations containing inorganic active ingredients
- A61K 33/06: Aluminium, calcium or magnesium; Compounds thereof {, e.g. clay}
- A61K 33/24: Heavy metals; Compounds thereof
- A61K 33/30: Zinc; Compounds thereof
- A61K 36/48: Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K 38/168: {from plants}
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61P 3/04: Anorexiants; Antiobesity agents
- A61P 3/06: Antihyperlipidemics
- A61P 3/10: for hyperglycaemia, e.g. antidiabetics
- A61P 21/06: Anabolic agents (androgens A61P5/26)
- A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION

## Abstract

Disclosed are combinations of soy protein, chromium and free leucine in amounts effective to inhibit the loss of lean body mass of a subject under conditions of caloric restriction. The soy protein, chromium and free leucine can be administered in several products, including a powder that is mixable into a liquid beverage (such as a shake), a snack bar, and a nutritional supplement (such as one or more tablets). Some embodiments also include corosolic acid and/or a tea drink that provides an effective dose of taurine. The products may be contained in kits containing the disclosed combinations as well as methods of using the products for weight loss and the inhibition of the loss of lean body mass in a subject during weight loss. The products and methods are also useful in the improvement of lipid profiles (for example reducing total cholesterol and LDL cholesterol levels).

## Claims

### Claim 1

A kit comprising:
a daily dosage of at least
Ingredient
Amount
soy protein isolate (g)
43.88
(providing
36.68 g of
soy protein)
fructose (g)
34.27
high oleic sunflower oil (g)
6.32
Acacia gum (g)
10.04
canola oil (g)
1.09
inulin (g)
0.95
short chain
4
fructoogligosacharides (g)
free leucine (g)
2.91
dicalcium phosphate (g)
1.98
silicon dioxide (g)
1.04
sodium citrate (g)
1.16
potassium chloride (g)
1.14
lecithin (g)
1.1
whey protein isolate (g)
1.8
guar gum (g)
0.74
flavoring (g)
6.28
vitamin premix (g)
0.2
mineral premix (g)
0.126
chromium (μg)
600
sweeteners (g)
4.94
medium chain triglycerides (g)
0.16
glycerine (g)
3.1
Banaba leaf extract (mg)
32
(providing
.32 mg of
corosolic
acid)
magnesium oxide (mg)
779.39
(providing
400 mg of
magnesium)
zinc gloconate (mg)
80.87
(providing
9.75 mg of
zinc)
taurine (mg)
800
vanadium amino acid chelate
100
(providing
100 μg
vanadium)
maltodextrin (g)
.49
tea extract (g)
.29
green tea powder (g)
.02
wherein the weight ratio of soy protein to free leucine is more than 10:1.

### Claim 2 (depends on 1)

The kit of claim 1, wherein the kit comprises multiple dosage forms, wherein the soy protein, chromium and free leucine are each distributed into more than one dosage form.

### Claim 3 (depends on 2)

The kit of claim 2, wherein the multiple dosage forms comprise a powdered shake mix, a consumable snack, and a supplement.

### Claim 4 (depends on 3)

The kit of claim 3, wherein the multiple dosage forms further comprise a tea preparation.

### Claim 5 (depends on 4)

The kit of claim 4, wherein the kit comprises the following dosage forms delivering the following daily dosages:
a shake mix delivering a daily dosage of 33.46 g soy protein from soy protein isolate (providing 28.3 g soy protein), 31 g fructose, 6.32 g high oleic sunflower oil, 9.7 g Acacia gum, 0.62 g canola oil, 4 g fructoogligosacharides, 2.4 free leucine, 1.98 g dicalcium phosphate, 1.04 g silicon dioxide, 1.16 g sodium citrate, 1.14 g potassium chloride, 1.1 g lecithin, 0.9 g whey protein isolate, 0.04 g guar gum, 1.5 g flavoring, 0.17 g vitamin premix, 0.126 g mineral premix, 200 μg chromium (provided from 0.002 g of chromium nicotinate), 560 mg magnesium oxide (providing 280 mg magnesium);
a consumable snack delivering a daily dosage of 10.42 g soy protein from soy protein isolate (providing 8.38 g soy protein), 4.17 g fructose, 0.34 g Acacia gum, 0.47 g canola oil, 0.95 g inulin, 0.51 g free leucine, 0.9 g whey protein isolate, 0.34 g guar gum, 4.69 g flavoring, 0.3 g, 4.94 g sweeteners, 0.16 g medium chain triglycerides, 3.1 g glycerine;
a supplement delivering a daily dosage of 400 μg chromium (μg) (provided from 0.00388 g of chromium nicotinate and 0.00753 g mineral protein hydrolysate), 32 mg Banaba leaf extract (providing 0.32 mg of corosolic acid), 219.39 mg magnesium oxide (providing 120 mg magnesium), 80.87 mg zinc gluconate (providing 9.75 mg of zinc), 4.75 mg vanadium amino acid chelate (providing 100 μg vanadium); and
a tea preparation delivering a daily dosage of 0.09 g flavoring flavoring, 800 mg taurine, 0.49 g, 0.29 g tea extract, 0.02 g green tea powder.

### Claim 6 (depends on 5)

The kit of claim 5, wherein the daily dosage of the ingredients in the shake mix dosage form is evenly distributed among two shakes.