# US 7,744,917 B2 · Composition for animal consumption and method for reducing MAP kinase activity > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 7,744,917 B2 - Document ID: US7744917B2 - Status: Granted - Kind: B2 - Application number: 10/997,384 - Filed: 2004-11-24 - Published: 2005-09-22 - Granted: 2010-06-29 - Earliest claimed: 2003-11-25 - Assignees: Virginia Intellectual Properties Inc. - Inventors: Kathy L. Gross; Inke Paetau-Robinson; Korinn E. Saker - Web page: https://patentgrep.com/patent/US7744917B2 ## CPC - A23K 50/40: for carnivorous animals, e.g. cats or dogs - A23K 20/147: Polymeric derivatives, e.g. peptides or proteins - A23K 20/158: Fatty acids; Fats; Products containing oils or fats - A23K 20/174: Vitamins - A23K 20/22: Compounds of alkali metals - A23K 20/24: Compounds of alkaline earth metals, e.g. magnesium - A23K 50/00: Feeding-stuffs specially adapted for particular animals - A61P 3/00: Drugs for disorders of the metabolism (of the blood or the extracellular fluid A61P7/00) - A61P 3/02: Nutrients, e.g. vitamins, minerals - A61P 35/00: Antineoplastic agents - A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 - A23K: FODDER - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS ## Abstract This invention is directed generally to compositions (including foods nutritional supplements, treats, and toys) for animal consumption, particularly compositions that comprise omega-3 and omega-6 polyunsaturated fatty acids, and particularly compositions that tend to aid in reducing mitogen-activated-protein (“MAP”) kinase activity in animals. This invention also is directed generally to methods for using such compositions, particularly to methods for using such compositions to reduce MAP kinase activity in animals, and particularly to methods for using such compositions to treat a cancer or tissue hyperplasia. This invention is further directed generally to processes for making such compositions. ## Claims ### Claim 1 A composition, wherein: the composition comprises: a fat content of about 8% by weight to about 35% by weight on a dry matter basis, a protein content of about 35% by weight to about 75% by weight on a dry matter basis, a carbohydrate content of less than 15% by weight on a dry matter basis, omega-3 polyunsaturated fatty acids; and omega-6 polyunsaturated fatty acids; wherein the weight ratio of the omega-6 polyunsaturated fatty acids to the omega-3 polyunsaturated fatty acids is from about 0.3:1 to about 5:1 wherein: the omega-3 polyunsaturated fatty acids comprise fatty acids having less than 20 carbon atoms and the concentration of omega-3 polyunsaturated fatty acids with less than 20 carbon atoms is from about 0.9% to about 1.2% by weight of the composition on a dry matter basis; and the omega-3 polyunsaturated fatty acids comprise fatty acids having greater than 20 carbon atoms and the concentration of omega-3 polyunsaturated fatty acids with greater than 20 carbon atoms is from about 4.2% to about 6.0% by weight of the composition on a dry matter basis; and the omega-6 polyunsaturated fatty acids comprise fatty acids having less than 20 carbon atoms and the concentration of omega-6 polyunsaturated fatty acids with less than 20 carbon atoms is from about 1.9% to about 4.8% by weight of the composition on a dry matter basis; and the omega-6 polyunsaturated fatty acids comprise fatty acids having greater than 20 carbon atoms and the concentration of omega-6 polyunsaturated fatty acids with greater than 20 carbon atoms is from about 1.0% to about 1.3% by weight of the composition on a dry matter basis. ### Claim 2 (depends on 1) A composition according to claim 1, wherein the carbohydrate content is less than 14% by weight on a dry matter basis. ### Claim 3 (depends on 2) A composition according to claim 2, wherein the carbohydrate content is less than 13% by weight on a dry matter basis. ### Claim 4 (depends on 3) A composition according to claim 3, wherein the carbohydrate content is less than 12% by weight on a dry matter basis. ### Claim 5 (depends on 4) A composition according to claim 4, wherein the carbohydrate content is less than 11% by weight on a dry matter basis. ### Claim 6 (depends on 1) A composition according to claim 1, wherein the fat content is from about 30% to about 35% by weight on a dry matter basis. ### Claim 7 (depends on 1) A composition according to claim 1, wherein the fat content is from about 13% to about 20% by weight on a dry matter basis. ### Claim 8 (depends on 1) A composition according to claim 1, wherein the protein content is from about 55% to about 65% by weight on a dry matter basis. ### Claim 9 (depends on 1) A composition according to claim 1, wherein: the omega-3 polyunsaturated fatty acids comprise fatty acids having less than 20 carbon atoms, and the omega-3 polyunsaturated fatty acids having less than 20 carbon atoms are present in the composition is from about 0.9% to about 1.2% by weight on a dry matter basis. ### Claim 10 (depends on 1) A composition according to claim 1, wherein: the omega-6 polyunsaturated fatty acids comprise fatty acids having less than 20 carbon atoms, and the omega-6 polyunsaturated fatty acids having less than 20 carbon atoms are present in the composition is from about 1.9% to about 4.8% by weight on a dry matter basis. ### Claim 11 (depends on 1) A composition according to claim 1, wherein: the omega-3 polyunsaturated fatty acids comprise fatty acids having greater than 20 carbon atoms, and the omega-3 polyunsaturated fatty acids having greater than 20 carbon atoms are present in the composition is from about 4.2% to about 6.0% by weight on a dry matter basis. ### Claim 12 (depends on 1) A composition according to claim 1, wherein: the omega-6 polyunsaturated fatty acids comprise fatty acids having greater than 20 carbon atoms, and the omega-6 polyunsaturated fatty acids having greater than 20 carbon atoms are present in the composition is from about 1.0% to about 1.3% by weight on a dry matter basis. ### Claim 13 (depends on 1) A composition according to claim 1, wherein the composition further comprises an ingredient selected from the group consisting of vitamins, minerals, flavorants and fibers. ### Claim 14 (depends on 1) A composition according to claim 1, wherein the omega-3 polyunsaturated fatty acid content is from about 2.5% to about 7.5% by weight on a dry matter basis. ### Claim 15 (depends on 1) A composition according to claim 1, wherein the omega-6 polyunsaturated fatty acid content is from about 2.0% to about 6.0% by weight on a dry matter basis. ### Claim 16 (depends on 1) A composition according to claim 1, comprising less than 1% by weight arginine. ### Claim 17 (depends on 1) A composition according to claim 1, wherein: the composition comprises: a fat content of from about 13% to about 20% by weight on a dry matter basis, a protein content of from about 55% to about 65% by weight on a dry matter basis, and a carbohydrate content of less than 11% by weight on a dry matter basis; and the omega-3 polyunsaturated fatty acids comprise fatty acids with less than 20 carbon atoms, and fatty acids with greater than 20 carbon atoms; and the omega-6 polyunsaturated fatty acids comprise fatty acids with less than 20 carbon atoms, and fatty acids with greater than 20 carbon atoms; wherein: the concentration of omega-3 polyunsaturated fatty acids with less than 20 carbon atoms is from about 0.9% to about 1.2% by weight of the composition on a dry matter basis; and the concentration of omega-3 polyunsaturated fatty acids with greater than 20 carbon atoms is from about 4.2% to about 6.0% by weight of the composition on a dry matter basis; and the concentration of omega-6 polyunsaturated fatty acids with less than 20 carbon atoms is from about 1.9% to about 4.8% by weight of the composition on a dry matter basis; and the concentration of omega-6 polyunsaturated fatty acids with greater than 20 carbon atoms is from about 1.0% to about 1.3% by weight of the composition on a dry matter basis. ### Claim 18 A composition, wherein: the composition comprises: a fat content of about 8% by weight to about 35% by weight on a dry matter basis, a protein content of about 49% by weight to about 75% by weight on a dry matter basis, a carbohydrate content of less than 30% by weight on a dry matter basis, omega-3 polyunsaturated fatty acids; and omega-6 polyunsaturated fatty acids; wherein the weight ratio of the omega-6 polyunsaturated fatty acids to the omega-3 polyunsaturated fatty acids is from about 0.3:1 to about 5:1 wherein: the omega-3 polyunsaturated fatty acids comprise fatty acids having less than 20 carbon atoms and the concentration of omega-3 polyunsaturated fatty acids with less than 20 carbon atoms is from about 0.9% to about 1.2% by weight of the composition on a dry matter basis; and the omega-3 polyunsaturated fatty acids comprise fatty acids having greater than 20 carbon atoms and the concentration of omega-3 polyunsaturated fatty acids with greater than 20 carbon atoms is from about 4.2% to about 6.0% by weight of the composition on a dry matter basis; and the omega-6 polyunsaturated fatty acids comprise fatty acids having less than 20 carbon atoms and the concentration of omega-6 polyunsaturated fatty acids with less than 20 carbon atoms is from about 1.9% to about 4.8% by weight of the composition on a dry matter basis; and the omega-6 polyunsaturated fatty acids comprise fatty acids having greater than 20 carbon atoms and the concentration of omega-6 polyunsaturated fatty acids with greater than 20 carbon atoms is from about 1.0% to about 1.3% by weight of the composition on a dry matter basis. ### Claim 19 (depends on 18) A composition according to claim 18, wherein the protein content is from about 50% to about 75% by weight on a dry matter basis. ### Claim 20 (depends on 19) A composition according to claim 19, wherein the protein content is from about 55% to about 65% by weight on a dry matter basis. ### Claim 21 (depends on 18) A composition according to claim 18, wherein the fat content is from about 8% to about 25% by weight on a dry matter basis. ### Claim 22 (depends on 18) A composition according to claim 18, wherein the fat content is from about 25% to about 35% by weight on a dry matter basis. ### Claim 23 (depends on 18) A composition according to claim 18, wherein the carbohydrate content is from about 6% to about 11% by weight on a dry matter basis. ### Claim 24 (depends on 18) A composition according to claim 18, comprising less than 1% by weight arginine. ### Claim 25 A composition, wherein: the composition comprises: a fat content of about 27% by weight on a dry matter basis, a protein content of about 35% by weight to about 75% by weight on a dry matter basis, a carbohydrate content of less than 30% by weight on a dry matter basis, omega-3 polyunsaturated fatty acids; and omega-6 polyunsaturated fatty acids; wherein the weight ratio of the omega-6 polyunsaturated fatty acids to the omega-3 polyunsaturated fatty acids is from about 0.3:1 to about 5:1 wherein: the omega-3 polyunsaturated fatty acids comprise fatty acids having less than 20 carbon atoms and the concentration of omega-3 polyunsaturated fatty acids with less than 20 carbon atoms is from about 0.9% to about 1.2% by weight of the composition on a dry matter basis; and the omega-3 polyunsaturated fatty acids comprise fatty acids having greater than 20 carbon atoms and the concentration of omega-3 polyunsaturated fatty acids with greater than 20 carbon atoms is from about 4.2% to about 6.0% by weight of the composition on a dry matter basis; and the omega-6 polyunsaturated fatty acids comprise fatty acids having less than 20 carbon atoms and the concentration of omega-6 polyunsaturated fatty acids with less than 20 carbon atoms is from about 1.9% to about 4.8% by weight of the composition on a dry matter basis; and the omega-6 polyunsaturated fatty acids comprise fatty acids having greater than 20 carbon atoms and the concentration of omega-6 polyunsaturated fatty acids with greater than 20 carbon atoms is from about 1.0% to about 1.3% by weight of the composition on a dry matter basis. ### Claim 26 (depends on 25) A composition according to claim 25, wherein the fat content is less than 25% by weight on a dry matter basis. ### Claim 27 (depends on 26) A composition according to claim 26, wherein the fat content is from about 8% to about 20% by weight on a dry matter basis. ### Claim 28 (depends on 25) A composition according to claim 25, wherein the carbohydrate content is from about 6% to about 11% by weight on a dry matter basis. ### Claim 29 (depends on 25) A composition according to claim 25, wherein the protein content is from about 50% to about 75% by weight on a dry matter basis. ### Claim 30 (depends on 25) A composition according to claim 25, comprising less than 1% by weight arginine. ### Claim 31 (depends on 1) An animal treat, toy, or nutritional supplement, wherein the treat, toy, or nutritional supplement comprises the composition recited in claim 1. ### Claim 32 (depends on 17) An animal treat, toy, or nutritional supplement, wherein the treat, toy, or nutritional supplement comprises the composition recited in claim 17. ### Claim 33 (depends on 18) An animal treat, toy, or nutritional supplement, wherein the treat, toy, or nutritional supplement comprises the composition recited in claim 18. ### Claim 34 (depends on 25) An animal treat, toy, or nutritional supplement, wherein the treat, toy, or nutritional supplement comprises the composition recited in claim 25.