# US 7,744,895 B2 · Methods of treating allergies using TGF-β1 and allergens

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- Number: US 7,744,895 B2
- Document ID: US7744895B2
- Status: Granted
- Kind: B2
- Application number: 11/363,371
- Filed: 2006-02-28
- Published: 2007-03-01
- Granted: 2010-06-29
- Earliest claimed: 2005-08-31
- Assignees: Yamanashi University
- Inventors: Atsuhito Nakao
- Web page: https://patentgrep.com/patent/US7744895B2

## CPC

- A61K 9/0053: {Mouth and digestive tract, i.e. intraoral and peroral administration}
- A61K 38/1841: {Transforming growth factor [TGF]}
- A61P 37/00: Drugs for immunological or allergic disorders
- A61P 37/08: Antiallergic agents (antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The invention provides an allergy prevention method or treatment method, diets and oral drugs enabling prevention/treatment of allergic symptoms without trouble such as systemic adverse reaction, immune deficiency and the like caused by transdermal/intravenous administration of TGF-β. The allergy prevention method or treatment method is to orally administer 100 μg/kg or more of transforming growth factor-beta (TGF-β) relative to a weight of an administration target body and thereby selectively suppress Th2 immune response, while with respect to the diets and oral drugs, the content is set to contain an effective amount of transforming growth factor-beta (TGF-β) therein.

## Claims

### Claim 1

A method of treating a food allergy, wherein said method comprises:
providing isolated transforming growth factor beta 1 (TGF-β1) in an amount of 100 μg/kg to 250 μg/kg, relative to a weight of an administration target body,
providing a causal substance of allergy,
combining the isolated TGF-β1 and causal substance of allergy,
administering orally and simultaneously the combination to the administration target body in need thereof,
wherein said causal substance of allergy is at least one food allergen and,
wherein the method of treating allergy results in a non-transient immunological response;
thereby treating the food allergy.

### Claim 2 (depends on 1)

The allergy treatment method according to claim 1, wherein the TGF-β1 is human TGF-β1.

### Claim 3 (depends on 1)

The method according to claim 1, wherein said administration target body is a human.

### Claim 4 (depends on 1)

The method according to claim 1, wherein said administration target body is a mouse.

### Claim 5 (depends on 1)

The method according to claim 1, wherein the combination is administered every other day for a total of six dosages.

### Claim 6 (depends on 1)

The method of treating allergy according to claim 1, wherein 5 μg of TGF-β1 are administered simultaneously with oral intake of the causal substance of allergy, to a mouse.

### Claim 7 (depends on 1)

The method according to claim 1, wherein the causal substance of allergy is administered to the target body in an amount of from 3 to 5 mg per gram of target body weight.

### Claim 8 (depends on 1)

The method of claim 1, wherein the food allergen is selected from the group consisting of milk, egg, rice, buckwheat, seafood and mixtures thereof.

### Claim 9 (depends on 1)

The method of claim 1, wherein the causal substance of allergy is ovalbumin of an egg.

### Claim 10 (depends on 1)

The method of claim 1, wherein the food allergen is in a milk product.

### Claim 11 (depends on 1)

The method of claim 1, wherein the food allergen is in a rice cake.

### Claim 12 (depends on 1)

The method of claim 1, wherein the food allergen is in a yogurt.

### Claim 13 (depends on 1)

The method of claim 1, wherein the food allergen is in a noodle.

### Claim 14 (depends on 1)

The method of claim 1, wherein the food allergen is in a flour.

### Claim 15 (depends on 1)

The method of claim 1, wherein the food allergen is in a pancake mix.

### Claim 16 (depends on 1)

The method of claim 1, wherein the food allergen is in a chocolate.

### Claim 17 (depends on 1)

The method of claim 1, wherein the food allergen is in a biscuit.

### Claim 18 (depends on 1)

The method of claim 1, wherein the food allergen is in a pudding.