# US 7,744,863 B1 · Method of inducing immune tolerance

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- Number: US 7,744,863 B1
- Document ID: US7744863B1
- Status: Granted
- Kind: B1
- Application number: 10/148,010
- Filed: 2000-11-24
- Granted: 2010-06-29
- Earliest claimed: 1999-11-26
- Inventors: Bruce Milne Hall; Suzanne Jean Hodgkinson
- Web page: https://patentgrep.com/patent/US7744863B1

## CPC

- C07K 16/2809: {against the T-cell receptor (TcR)-CD3 complex}
- A61K 38/2033: {IL-5}
- A61K 39/39541: {against normal tissues, cells}
- A61P 37/06: Immunosuppressants, e.g. drugs for graft rejection
- A61K 2039/505: {comprising antibodies}
- A61K 2039/57: {characterised by the type of response, e.g. Th1, Th2}
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

A method of inhibiting Th1 immune response in a subject in need of such treatment which comprises administering to the subject effective amounts for inhibiting Th1 immune response of an anti-CD3 monoclonal antibody and IL-5 or an analogue or mimetic thereof.

## Claims

### Claim 1

A method of inhibiting Th1 immune response in a mammalian subject suffering from an autoimmune disease, which method comprises administering to the mammalian subject effective amounts of an anti-CD3 monoclonal antibody and IL-5, or an anti-CD3 monoclonal antibody and an analogue of IL-5, wherein the autoimmune disease is selected from the group consisting of: type I diabetes, multiple sclerosis, rheumatoid arthritis, psoriasis, glomerulonephritis, myasthenia gravis, chronic inflammatory demyelinating neuropathy and inflammatory bowel disease.

### Claim 2 (depends on 1)

The method according to claim 1 wherein the anti-CD3 monoclonal antibody does not bind to Fc receptors.

### Claim 3 (depends on 1)

The method according to claim 1, wherein the subject is human.

### Claim 4 (depends on 3)

The method according to claim 3 wherein the antibody is a humanised anti-CD3 monoclonal antibody.

### Claim 5 (depends on 3)

The method according to claim 3 wherein the IL-5 is recombinant human IL-5.