# US 7,744,856 B2 · Formulations with feruloyl glycerides and methods of preparation

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- Number: US 7,744,856 B2
- Document ID: US7744856B2
- Status: Granted
- Kind: B2
- Application number: 11/771,843
- Filed: 2007-06-29
- Published: 2008-02-28
- Granted: 2010-06-29
- Earliest claimed: 2005-10-03
- Assignees: Biotech Research and development Corporation
- Inventors: Louis J. DeFilippi; Steven G. Grall; James F. Kinney; Joseph A. Laszlo; David L. Compton
- Web page: https://patentgrep.com/patent/US7744856B2

## CPC

- A61K 8/375: {the alcohol moiety containing more than one hydroxy group}
- A61K 8/347: {Phenols}
- A61Q 5/12: Preparations containing hair conditioners
- A61Q 9/02: Shaving preparations
- A61Q 13/00: Formulations or additives for perfume preparations (essential oils or perfumes per se C11B9/00)
- A61Q 17/04: Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
- A61Q 19/00: Preparations for care of the skin
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

A product for topical application comprising a chemical composition comprising in combination a linker agent and a compound comprising at least one UV-absorbing chromophore, wherein the linker agent is characterized by the general formula: wherein: X1 and X2 are the same or different, and at least one of X1 or X2 is a functional group that bonds with the compound comprising at least one UV-absorbing chromophore, and b+f≧2; Y comprises an O, N, or S that is substituted or unsubstituted; each a, b, c, e and f is ≧0 and a+b+c+e+f≧2; d is 0 or 1; n1 and n2 represent the number of hydrogen atoms required to complete the undesignated valencies; and m ranges from 1 to about 100 and each individual m unit may be the same or different, and a topically acceptable agent that is different from the linker agent and the compound comprising at least one UV-absorbing chromophore.

## Claims

### Claim 1

A vitamin complex lotion comprising: water; hydroxyethylcellulose; glycerin; ascorbic acid; phytonadione; biotin; stearyl alcohol; glyceryl stearate; squalane; olive oil amidopropyl phosphatidyl PG-dimonium chloride; tocopherol acetate; retinyl palmitate; cholecalciferol; linoleic acid; PEG-40 stearate; a UV-absorbing compound; ubiquinone 50; cyclomethicone; Steareth-20; fragrance; phenoxyethanol; and methylparaben,
wherein the UV-absorbing compound comprises a linker agent having the general formula:
wherein:
X1 and X2 are the same or different, and at least one of X1 or X2 is a functional group bound with ferulic acid, and b+f≧2;
Y comprises an O, N, or S that is substituted or unsubstituted;
each a, b, c, e and f is ≧0 and a+b+c+e+f≧2;
d is 1;
n1 and n2 represent the number of hydrogen atoms required to complete the undesignated valencies; and
m ranges from 1 to about 100 and each individual m unit may be the same or different.

### Claim 2 (depends on 1)

The vitamin complex lotion of claim 1, wherein the lotion comprises: approximately 69.8 wt. % water; approximately 2.0 wt. % hydroxyethylcellulose; approximately 5.0 wt. % glycerin; approximately 2.8 wt. % ascorbic acid; approximately 0.1 wt. % phytonadione; approximately 0.1 wt. % biotin; approximately 3.0 wt. % stearyl alcohol; approximately 2.0 wt. % glyceryl stearate; approximately 0.5 wt. % squalane; approximately 0.5 wt. % olive oil amidopropyl phosphatidyl PG-dimonium chloride; approximately 3.0 wt. % tocopherol acetate; approximately 0.5 wt. % retinyl palmitate; approximately 0.5 wt. % cholecalciferol; approximately 0.5 wt. % linoleic acid; approximately 2.0 wt. % PEG-40 stearate; approximately 5.0 wt. % UV-absorbing compound; approximately 0.1 wt. % ubiquinone 50; approximately 1.0 wt. % cyclomethicone; approximately 0.9 wt. % Steareth-20; approximately 0.2 wt. % fragrance; approximately 0.3 wt. % phenoxyethanol; and approximately 0.2 wt. % methylparaben.

### Claim 3

A vitamin complex lotion comprising at least one vitamin and a UV-absorbing compound,
wherein the UV-absorbing compound comprises a linker agent having the general formula:
wherein:
X1 and X2 are the same or different, and at least one of X1 or X2 is a functional group bound with ferulic acid, and b+f≧2;
Y comprises an O, N, or S that is substituted or unsubstituted;
each a, b, c, e and f is ≧0 and a+b+c+e+f≧2;
d is 1;
n1 and n2 represent the number of hydrogen atoms required to complete the undesignated valencies; and
m ranges from 1 to about 100 and each individual m unit may be the same or different, and
wherein the amount of UV-absorbing compound is about 5% by weight.

### Claim 4 (depends on 3)

The vitamin complex lotion of claim 3, further comprising Vitamin C, wherein the amount of Vitamin C is about 2.8% by weight.

### Claim 5 (depends on 3)

The vitamin complex lotion of claim 3, further comprising Vitamin K, wherein the amount of Vitamin K is about 0.1% by weight.

### Claim 6 (depends on 3)

The vitamin complex lotion of claim 3, further comprising Vitamin B7, wherein the amount of Vitamin B7 is about 0.1% by weight.

### Claim 7 (depends on 3)

The vitamin complex lotion of claim 3, further comprising Vitamin E, wherein the amount of Vitamin E is about 3.0% by weight.

### Claim 8 (depends on 3)

The vitamin complex lotion of claim 3, further comprising Vitamin A, wherein the amount of Vitamin A is about 0.5% by weight.

### Claim 9 (depends on 3)

The vitamin complex lotion of claim 3, further comprising Vitamin D3, wherein the amount of Vitamin D3 is about 0.5% by weight.

### Claim 10 (depends on 3)

The vitamin complex lotion of claim 3, further comprising Vitamin F, wherein the amount of Vitamin F is about 0.5% by weight.