# US 7,744,820 B2 · Plasma or serum separation membrane and filter apparatus including the plasma or serum separation membrane

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- Number: US 7,744,820 B2
- Document ID: US7744820B2
- Status: Granted
- Kind: B2
- Application number: 11/635,239
- Filed: 2006-12-07
- Published: 2007-04-12
- Granted: 2010-06-29
- Earliest claimed: 2005-05-02
- Inventors: Katsuya Togawa; Ryusuke Okamoto; Hironobu Isogawa
- Web page: https://patentgrep.com/patent/US7744820B2

## CPC

- B01D 69/02: characterised by their properties
- B01D 61/18: Apparatus therefor
- B01L 3/502: {with fluid transport, e.g. in multi-compartment structures}
- G01N 33/491: {by separating the blood components (G01N15/05 takes precedence)}
- B01L 3/5082: {Test tubes per se}
- B01L 2300/047: Additional chamber, reservoir
- B01L 2300/0681: Filter
- B01L 2400/0487: fluid pressure, pneumatics
- Y10T 436/11: Automated chemical analysis
- Y10T 436/25: including sample preparation
- Y10T 436/25125: Digestion or removing interfering materials
- Y10T 436/25375: Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
- Y10T 436/255: including use of a solid sorbent, semipermeable membrane, or liquid extraction
- B01D: SEPARATION (separating solids from solids by wet methods B03B, B03D; by pneumatic jigs or tables B03B; by other dry methods B07; magnetic or electrostatic separation of solid materials from solid materials or fluids, separation by high-voltage electric fields B03C; centrifuges, vortex apparatus B04; presses per se for squeezing-out liquid from liquid-containing material B30B9/02; treatment of water C02F, e.g. softening by ion-exchange C02F1/42; {arrangements of air intake cleaners in gas turbine plants F02C7/05} ; arrangements or mounting of filters in air-conditioning, air-humidification or ventilation F24F13/28)
- B01L: CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)
- Y10T: TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION

## Abstract

A Plasma or serum separation membrane that enables omitting centrifugal separation, is free from hemolysis attributed to destruction of red blood cells and realizes easy and rapid separation of plasma or serum from blood; and a filter apparatus including the plasma or serum separation membrane. In particular, a plasma or serum separation membrane being a membrane for separation of plasma or serum from blood and having a void ratio of 30% or below; and a filter apparatus comprising a filter member capable of attaining movement of plasma swifter than movement of blood cells and a plasma or serum separation membrane connected in series with a rear side of the filter member.

## Claims

### Claim 1

A membrane for separating plasma or serum from blood, said membrane being formed from a polymer selected from the group consisting of polycarbonate and polyethylene terephthalate, and having a plurality of through holes provided therein so as to penetrate therethrough and extend from one side to an opposite side thereof, each of said through holes having a diameter of from 0.05 to 2.0 μm,
wherein said membrane has a porosity of not more than 30%, and a mean surface roughness of not more than 100 nm.