Apparatus and methods for forming and securing gastrointestinal tissue folds

A method of performing gastric reduction procedure comprising:

• advancing an anchor delivery device through a patient's esophagus into the patient's stomach, the anchor delivery device including a needle defining a lumen;
• endoscopically forming and approximating a first plurality of tissue folds in a first plane within the patient's stomach;
• piercing at least one of the first plurality of tissue folds with the needle;
• ejecting a first anchor from the needle across the at least one tissue fold;
• and
• endoscopically forming, approximating and securing at least one additional plurality of tissue folds in at least one additional plane within the patient's stomach, with the anchor delivery device being used for securing the at least one additional plurality of tissue folds.

A method of performing gastric reduction comprising:

• advancing an anchor delivery device through a patient's esophagus into the patient's stomach, the anchor delivery device including a needle defining a lumen;
• endoscopically forming and approximating a first tissue fold at a first location within the patient's stomach;
• piercing the first tissue fold with the needle;
• ejecting a first anchor from the needle on a first side of the first tissue fold;
• withdrawing the needle from the first tissue fold;
• ejecting a second anchor from the needle on a second side of the first tissue fold, with a connector extending between the first anchor and the second anchor;
• endoscopically forming, approximating and securing at least one additional tissue fold in at least one additional location within the patient's stomach, with the anchor delivery device being used for securing the at least one additional tissue fold;
• and
• approximating and securing the first tissue fold and the at least one additional tissue fold.