# US 7,744,590 B2 · Red to near-infrared photobiomodulation treatment of the visual system in visual system disease or injury

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- Number: US 7,744,590 B2
- Document ID: US7744590B2
- Status: Granted
- Kind: B2
- Application number: 12/056,458
- Filed: 2008-03-27
- Published: 2009-03-05
- Granted: 2010-06-29
- Earliest claimed: 2003-01-17
- Assignees: The Medical College of Wisconsin Research Foundation, Inc.
- Inventors: Janis T. Eells; Margaret T. T. Wong-Riley; Harry T. Whelan
- Web page: https://patentgrep.com/patent/US7744590B2

## CPC

- A61N 5/0613: {Apparatus adapted for a specific treatment}
- A61N 2005/0652: {Arrays of diodes}
- A61N 2005/0659: {infrared}
- A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B)

## Abstract

A method of treating visual system disease is disclosed. One embodiment comprises the steps of (a) exposing a component of a patient's visual system to light treatment, wherein the light treatment is characterized by wavelength of between 630-1000 nm and power intensity between 10-90 mW/cm2 for a time of 1-3 minutes, and (b) observing restoration of visual system function.

## Claims

### Claim 1

A method of treating visual system disease or injury, comprising the steps of
a) exposing a component of a patient's visual system to light treatment in the absence of an exogenous photosensitizer, wherein the light treatment is characterized by a wavelength of 630-1000 nm and power intensity between 10-90 mW/cm2, and
b) performing one or more tests measuring visual function, wherein the test results indicate an increase in metabolically active neurons.

### Claim 2 (depends on 1)

The method of claim 1 wherein the wavelength is selected from the group consisting of 670 nm, 830 nm and 880 nm.

### Claim 3 (depends on 1)

The method of claim 1 wherein the wavelength is between 670-900 nm.

### Claim 4 (depends on 1)

The method of claim 1 wherein the light treatment is characterized by an energy density of between 0.5-20 J/cm2.

### Claim 5 (depends on 4)

The method of claim 4 when the energy density is between 2-10 j/cm2.

### Claim 6 (depends on 1)

The method of claim 1 wherein the patient is exposed to light treatment multiple times.

### Claim 7 (depends on 6)

The method of claim 6 wherein the exposure is at least 3 times.

### Claim 8 (depends on 6)

The method of claim 6 wherein the patient is exposed to light treatment at intervals of 24 hours.

### Claim 9 (depends on 1)

The method of claim 1 wherein the component of the visual system comprises the patient's retina.

### Claim 10 (depends on 1)

The method of claim 1 wherein the component of the visual system is selected from the group consisting of cornea and optic nerve.

### Claim 11 (depends on 1)

The method of claim 1 wherein the retinal function is evaluated.

### Claim 12 (depends on 1)

The method of claim 1 wherein the light is supplied by an LED device.

### Claim 13 (depends on 1)

The method of claim 1 wherein the power intensity is between 25-50 mW/cm2.

### Claim 14

A method of treating visual system disease or injury, comprising the steps of
a) exposing a component of a patient's visual system to light treatment in the absence of an exogenous photosensitizer, wherein the light treatment is characterized by wavelength of 630-1000 nm and power intensity between 10-90 mW/cm2, and
b) performing electroretinography (ERG) to observe restoration or protection of visual function, wherein rod and cone ERG amplitude has increased relative to tissue that hasn't been exposed to the light treatment.

### Claim 15 (depends on 14)

The method of claim 14 wherein the light treatment is applied for a time of 1-3 minutes.

### Claim 16 (depends on 14)

The method of claim 14 wherein the light is supplied by an LED device.

### Claim 17 (depends on 1)

The method of claim 1 wherein the light treatment is applied for a time of 1-3 minutes.

### Claim 18 (depends on 1)

The method of claim 1 wherein the light treatment is applied at least 2-3 times a day.

### Claim 19 (depends on 1)

The method of claim 1 wherein the patient is a human.