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US 7,741,521 B2Granted
Inhibition of bid-induced cell-death using small organic molecules
AssigneeThe Burnham Institute
InventorsJohn C. Reed, Maurizio Pellecchia
Life of this patent
Estimating the term…
Abstract
Various phenylamine derivatives are described as well as the use of compounds to inhibit BID protein for controlling apoptotic cascade.
Claims8
A compound having the formula (A):
- wherein each of R1 and R2 is independently selected from a group consisting of:
- Y is a moiety selected from a group consisting of:
- X is a moiety selected from a group consisting of:
- R3 is at least one substitutent in ortho-, meta-, or para-position of the benzene ring, wherein “(R3)1-5” symbolizes that the number of R3 substitutents is between 1 and 5, inclusively, wherein R3 is selected from a group consisting of:
- n is an integer having the value between 1 and 5;
- and
- Ph in any of R1, R2, and R3 is independently selected from an unsubstituted phenyl ring and a substituted phenyl ring having between one and five substitutents in ortho-, meta-, or para-position of the benzene ring, wherein the substitutents in the ring are selected from the group consisting of:
- or a pharmaceutically acceptable salt thereof.
5 more elements
A compound having the formula C:
- wherein each of R1 and R2 is independently selected from a group consisting of:
- Y is a moiety selected from a group consisting of:
- X is a moiety selected from a group consisting of:
- R3 is at least one substitutent in ortho-, meta-, or para-position of the benzene ring, wherein “(R3)1-5” symbolizes that the number of R3 substitutents is between 1 and 5, inclusively, wherein R3 is selected from a group consisting of:
- n is an integer having the value between 1 and 5;
- and
- Ph in any of R1, R2, and R3 is independently selected from an unsubstituted phenyl ring and a substituted phenyl ring having between one and five substitutents in ortho-, meta-, or para-position of the benzene ring, wherein the substitutents in the ring are selected from the group consisting of:
4 more elements
Dependencies are inferred from the claim text.