Indoline-sulfonamides compounds
AssigneesTaipei Medical University, National Health Research Institutes
InventorsJing-Ping Liou, Jang-Yang Chang, Hsing-Pang Hsieh
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Abstract
A series of indoline-sulfonamide compounds is disclosed. The formula of indoline-sulfonamide compounds is shown as formula (I). In formula (I), R1 is H or halogen; R2 is Ar, Ar—C(O)—, Ar—CH2—, Ar—SO2—, Ar—O—C(O), or R″—C(O)—, and Ar is a substituted or unsubstituted C5-C20 aryl, cyclyl, heterocyclyl, or heteroaryl, R′ and R″ independently is C1-C10 alkyl, or C1-C10 alkoxyl; and R3 is C5-C15 aryl or C1-C10 alkyl. The indoline-sulfonamide compounds disclosed in the present invention are characterized in inhibiting tubulin polymerization, and treating cancers and other tubulin polymerization-related disorders with a suitable pharmaceutical acceptable carrier.
Claims25
An indoline-sulfonamide compound of the following formula (I):
- wherein R1 is H, or halogen;
- R2 is H, Ar, Ar—C(O)—, Ar—CH2—, Ar—SO2—, Ar—O—C(O),
- R″—C(O)—, and Ar is substituted or unsubstituted C5-C20 aryl, cyclyl,
- R′ and R″ independently, is C1-C10 alkyl, or C1-C10 alkoxyl;
- and
- R3 are C5-C15 aryl or C1-C10 alkyl.
Dependencies are inferred from the claim text.