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US 7,741,489 B2Granted
Process for the synthesis of solifenacin
AssigneeMedichem, S.A.
InventorsJordi Puig Serrano, Pelayo Camps
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Abstract
The present invention provides an improved synthetic strategy for the preparation of solifenacin and pharmaceutically acceptable salts thereof.
Claims17
A process for preparing solifenacin base (Ia),
- said process comprising:
- (i) reacting (3R)-3-quinuclidinol (II),
- with 1,1-carbonyl-di-(1,2,4-triazole) (III),
- in an organic solvent to obtain a mixture, and
- (ii) combining the mixture of step (i) with (S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline (V),
- in the presence of a base to obtain solifenacin base.
3 more elements
Dependencies are inferred from the claim text.