Back to results
US 7,741,477 B2Granted
Process for purification of sucralose
AssigneeAlembic Limited
InventorsPandurang Balwant Deshpande, Parven Kumar Luthra, Sanjiv Onkarsingh Tomer, Piyush Maheshbhai Rana, Jigar Kamleshbhai Patel
Life of this patent
Estimating the term…
Abstract
The present invention relates to a process for the purification of Sucralose of formula (I) which comprises acetylation of substantially impure Sucralose to its penultimate intermediate 4,1′,6′-trichloro-4,1′,6′-trideoxy galactosucrose penta-acetate (TOPSA) of formula (VI) followed by purification of TOPSA and then deacetylation of purified TOPSA.
Claims2
A process for purification of substantially impure Sucralose of formula (I) to obtain sucralose having at least 99% purity, said process comprising steps of:
- (i) converting substantially impure Sucralose to its penultimate 4,1′,6′-trichloro-4,1′,6′-trideoxy galactosucrose penta-acetate (TOPSA) of formula (VI) by acetylation;
- wherein the step (i) acetylation is carried out in the presence of acetic anhydride, pyridine and dichloromethane;
- (ii) purifying the TOPSA obtained in above step (i);
- wherein the step (ii) purification is carried out as a single round of crystallization from methanol;
- and
- (iii) converting TOPSA obtained in above step (ii) to Sucralose by deacetylation.
3 more elements
Dependencies are inferred from the claim text.