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US 7,741,474 B2Granted
Solubilising polysaccharides substituted with dydrophilic and hydrophobic groups
AssigneeThe School of Pharmacy, University of London
InventorsIjeoma Uchegbu, Andreas Schatzlein, Ailsa Stewart, Clive Wilson
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Abstract
This invention relates to novel carbohydrate polymers with hydrophobic and hydrophilic side-groups suitable for solubilising, for example, hydrophobic drugs. The chain length of the carbohydrate polymeric backbone, and the type and number of the hydrophobic and hydrophilic side-groups are specifically chosen to improve the solubility properties of the carbohydrate polymers.
Claims20
A solubilising carbohydrate polymer of average molecular weight of about 2-30 kD according to the following formula:
- wherein m is 0.01% to 10.00%;
- n is 0.01% to 99.98%;
- p is 0.00% to 99.98%
- X is any hydrophobic, linear, branched or cyclo form of an alkyl, alkenyl, alkynyl, aryl, amine, amide, alcohol or acyl group;
- R′, R″, R′″ are independently any linear, branched or cyclo form of an alkyl, alkenyl, alkynyl, aryl, acyl group, a sugar substituent selected from glucose, galactose, fructose and muramic acid, or oligo polyoxa C1-C3 alkylene units, optionally substituted with amine, amide or alcohol;
- and
- R1, R2 and R3 are independently any linear, branched, or cyclo forms of any alkyl, alkenyl, alkynyl, aryl or acyl group.
4 more elements
Dependencies are inferred from the claim text.