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US 7,741,471 B2Granted
Reagents for the improved synthesis of isoguanosine containing oligonucleotides
AssigneeEraGen Biosciences, Inc.
InventorsJames R. Prudent, Christopher B. Sherrill
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Abstract
The present invention provides the combination of the O-2 diphenylcarbamoyl (“DPC”) and N-6 dimethylaminomethylidene (“DMF”) protecting groups for isoguanosine nucleosides that can be utilized in oligonucleotide synthesis.
Claims12
A compound of the formula:
A compound of the formula:
- wherein
- E is an acid labile protecting group;
- A is an O-phosphoramidite protecting group orthogonal to E;
- D is NT1T2 wherein
- T1 and T2 are each, independently, a substituted or unsubstituted aliphatic group, a substituted or unsubstituted aromatic group, a substituted or unsubstituted aralkyl group;
- or
- T1 and T2 taken together with the nitrogen to which they are bonded form a heterocycloalkyl group or a herteroaromatic group;
- and
- G1 and G2 are substituted or unsubstituted hydrocarbon radicals.
6 more elements
Dependencies are inferred from the claim text.