Compositions for treating hearing loss and methods of use thereof
AssigneeUniversity of Iowa Research Foundation
InventorRichard J. Smith
Life of this patent
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Abstract
This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of genes encoding proteins involved in deafness caused by dominant negative mechanism of action by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid, short interfering RNA, double-stranded RNA (dsRNA), micro-RNA (mRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of genes involved in deafness caused by dominant negative mechanism of action.
Claims16
A composition comprising an isolated RNA molecule comprising a first portion, wherein the first portion is no more than 30 nucleotides in length, wherein the first portion comprises a sequence that is complementary to target sequence 5′-AAC GTG TGC TAC GAT CAC TAC-3′ (siRNA1;
- SEQ ID NO:1).
Dependencies are inferred from the claim text.