Long lasting fusion peptide inhibitors for HIV infection
AssigneeConjuChem Biotechnologies Inc.
InventorsJohn W. Erickson, Dominique P. Bridon, Martin Robitaille, Grant A. Krafft, Dong Xie, Elena Afonina, Jun Liang, Sandra DeMeyer
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Abstract
The present invention relates to C34 peptide derivatives that are inhibitors of viral infection and/or exhibit antifusogenic properties. In particular, this invention relates to C34 derivatives having inhibiting activity against human immunodeficiency virus (HIV), respiratory syncytial virus (RSV), human parainfluenza virus (HPV), measles virus (MeV), and simian immunodeficiency virus (SIV) with long duration of action for the treatment of the respective viral infections.
Claims73
A compound of Formulae I-VIII corresponding in order of appearance to SEQ ID NOS:
- 2, 3, 4, 5, 6, 7, 8 and 9:
- or a compound according to any of Formulae I-VI further comprising an N-terminal acetyl group.
Dependencies are inferred from the claim text.