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US 7,741,452 B2Granted
Glycosylation-deficient hepatocyte growth factor
AssigneeToshikazu Nakamura
InventorsToshikazu Nakamura, Kunio Matsumoto, Kazuhiro Fukuta
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Abstract
The invention provides a modified glycosylation-deficient HGF and a production method thereof. The glycosylation-deficient HGF is produced by introducing amino acid mutation(s) so that no glycosylation take place at at least one glycosylation site of hepatocyte growth factor.
Claims1
A glycosylation-deficient hepatocyte growth factor having no sugar chains, and having an amino acid sequence wherein the amino acids 289, 397, 561 and 648 are substituted by Gln and the amino acid 471 is substituted by Gly in the amino acid sequence represented by SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.