Back to results
US 7,741,448 B2Granted
Antibody having inhibitory effect on amyloid fibril formation
AssigneesMedical & Biological Laboratories Co., Ltd., The President of National Center for Geriatrics and Gerontology, Katsuhiko Yanagisawa
InventorsKatsuhiko Yanagisawa, Masao Shibata
Life of this patent
Estimating the term…
Abstract
Disclosed is an antibody having a high inhibitory effect on amyloid fibril formation. An antibody is produced by using a liposome containing a GM1 ganglioside at a predetermined ratio as an immunogen. Thus, the sequences of four types of antibodies each having a high inhibitory effect on amyloid fibril formation can be provided.
Claims4
An isolated antibody comprising a combination of a heavy chain variable region and a light chain variable region selected from the group consisting of
- (a) a combination of a heavy chain variable region having an amino acid sequence of SEQ ID NO:
- 17 and having a CDR including a heavy chain CDR1 having an amino acid sequence of SEQ ID NO:
- 18, a heavy chain CDR2 having an amino acid sequence of SEQ ID NO:
- 19, and a heavy chain CDR3 having an amino acid sequence of SEQ ID NO:
- 20, and a light chain variable region having an amino acid sequence of SEQ ID NO:
- 21 and having a CDR including CDR1 having an amino acid sequence of SEQ ID NO:
- 22, CDR2 having an amino acid sequence of SEQ ID NO:
- 23, and CDR3 having an amino acid sequence of SEQ ID NO:
- 24;
- and
- wherein the antibody recognizes GM1 ganglioside-bound amyloid β-protein.
8 more elements
Dependencies are inferred from the claim text.