Antibody against tumor specific antigen as target
AssigneeSankyo Company, Limited
InventorsKimihasa Ichikawa, Shu Takahashi, Toshinori Agatsuma, Keisuke Fukuchi, Takehiro Hirai
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Abstract
The present invention relates to a method of detecting cancer by use of an oncogene, a method of screening for an active compound useful to treat and/or prevent cancer, and a pharmaceutical composition for treatment and/or prevention of cancer. More specifically, the present invention provides a method of detecting cancer based on the expression of the human oculospanin gene as a marker and a pharmaceutical composition containing an antibody capable of specifically recognizing human oculospanin and having cytotoxic activity against cancer cells.
Claims3
A humanized antibody which
- a) binds to a human oculospanin protein selected from the group consisting of SEQ ID NO:2 and SEQ ID NO:4, and
- b) has cytotoxic activity against a cell expressing said oculospanin protein,
- wherein said humanized antibody comprises the entire CDR regions of the variable heavy chain and variable light chain of the anti-human oculospanin antibody produced by mouse hybridoma O3B8-2C9-4F3 (FERM BP-08627), a partial amino acid sequence of the framework region of the anti-human oculospanin antibody produced by mouse hybridoma O3B8-2C9-4F3 (FERM BP-08627), and a partial human antibody framework.
A humanized antibody which
- a) binds to a human oculospanin protein selected from the group consisting of SEQ ID NO:2 and SEQ ID NO:4, and
- b) has cytotoxic activity against a cell expressing said oculospanin protein,
- wherein said humanized antibody is humanized by the process of:
- providing a partial human antibody framework;
- and
- transplanting into said partial human antibody framework the entire CDR regions of the variable heavy chain and variable light chain of the anti-human oculospanin antibody produced by mouse hybridoma O3B8-2C9-4F3 (FERM BP-08627), and at least a partial amino acid sequence of the framework region of the anti-human oculospanin antibody produced by mouse hybridoma O3B8-2C9-4F3 (FERM BP-08627).
Dependencies are inferred from the claim text.