Neoplasm specific antibodies and uses thereof
AssigneePatrys Limited
InventorsHans-Konrad Mueller-Hermelink, Heinz Peter Vollmers
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Abstract
The present invention features polypeptides, such as antibodies, and their use in the treatment and diagnosis of neoplasms.
Claims19
A purified antibody or antigen binding fragment thereof comprising a light chain (VL) variable region sequence and a heavy chain (VH) variable region sequence, wherein the light chain (VL) variable region sequence comprises amino acids 26-31, 49-51, and 88-95 of SEQ ID NO:1, or wherein the heavy chain (VH) variable region sequence comprises amino acids 11-18, 36-43, and 82-90 of SEQ ID NO:3, and wherein said antibody or antigen binding fragment specifically binds to an epitope of a polypeptide expressed by at least one of ASPC-1 (ATCC Accession No. CRL-1682), or BXPC-3 (ATCC Accession No. CRL-1687) cells, and wherein PM-1 antibody produced by a cell line deposited as DSM ACC 2599 specifically binds to said epitope of the polypeptide expressed by at least one of ASPC-1(ATCC Accession No. CRL-1682), or BXPC-3 (ATCC Accession No. CRL-1687) cells.
A purified antibody or antigen binding fragment comprising the amino acid sequence of SEQ ID NOS:1 and 3.
A purified antibody or antigen binding fragment comprising a light chain (VL) variable region sequence and a heavy chain (VH) variable region sequence, wherein the light chain (VL) variable region comprises amino acid 26-31, 49-51, and 88-95 of SEQ ID NO:1 and wherein the heavy chain (VH) variable region comprises amino acids 11-18, 36-43, and 82-90 of SEQ ID NO:3.
A purified antibody produced by the PM-1 cell line having DSMZ Accession No. DSM ACC2599.
Dependencies are inferred from the claim text.