Antibody composition exhibiting increased cellular cytotoxicity due to glycosylation
AssigneeKyowa Hakko Kirin Co., Ltd.
InventorsYutaka Kanda, Mitsuo Satoh, Kazuyasu Nakamura, Kazuhisa Uchida, Toyohide Shinkawa, Naoko Yamane, Emi Hosaka, Kazuya Yamano, Motoo Yamasaki, Nobuo Hanai
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Abstract
The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.
Claims4
An antibody composition comprising antibody molecules, wherein 50% or more of the molecules comprise a Fc region comprising complex N-glycoside-linked sugar chains bound to the Fc region,
- wherein said sugar chains comprise a reduced terminal which contains an N-acetylglucosamine;
- wherein said sugar chains do not contain fucose bound to the 6-position of the N-acetylglucosamine in the reducing terminal of the sugar chains;
- and
- wherein said antibody molecules bind to an antigen selected from the group consisting of ganglioside GD3, ganglioside GM2, HER-2, a vascular endothelial cell growth factor receptor, CCR4, an interleukin-5 receptor and a tumor necrosis factor.
Dependencies are inferred from the claim text.