Apoptin-associating protein
AssigneeLeadd B.V.
InventorsMathieu Hubertus M. Noteborn, Astrid Adriana A. M. Danen-van Oorschot, Jennifer Leigh Rohn, Bertram Weiss, Luisella Toschi
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Abstract
The invention relates to the field of apoptosis. The invention provides novel therapies, for example, novel combinatorial therapies or novel therapeutic compounds that can work alone, sequentially to, or jointly with Apoptin, especially in those cases wherein p53 is completely or partially non-functional.
Claims14
An isolated or recombinant proteinaceous substance encoded by SEQ ID NO:13 or by a nucleic acid at least 90% homologous to the nucleic acid sequence of SEQ ID NO:10.
An isolated or recombinant proteinaceous substance comprising an amino acid sequence at least 90% homologous to SEQ ID NO:12.
An isolated or synthetic antibody that specifically recognizes a proteinaceous substance comprising an amino acid sequence at least 90% homologous to SEQ ID NO:12.
A method of inducing apoptosis in a cell, said method comprising:
- providing a host cell with a nucleic acid that encodes a proteinaceous substance comprising an amino acid sequence at least 90% homologous to SEQ ID NO:12, so that apoptosis is induced in the host cell.
A method of inducing apoptosis, said method comprising:
- providing a host cell with a proteinaceous substance that comprises an amino acid sequence at least 90% homologous to SEQ ID NO:
- 12, whereby apoptosis is induced.
A method of treating a disease where enhanced cell proliferation or decreased cell death is observed in an individual, said method comprising:
- providing an individual in need thereof with a pharmaceutical composition comprising a proteinaceous substance that comprises an amino acid sequence at least 90% homologous to SEQ ID NO:12,
- so that said disease is treated.
An isolated or recombinant proteinaceous substance encoded by a nucleic acid selected from the group consisting of SEQ ID NO:13, a nucleic acid at least 90% homologous to the nucleic acid sequence of SEQ ID NO:
- 10, and combinations thereof.
Dependencies are inferred from the claim text.