Methods for producing macromolecule-identifying polymers
AssigneeReqMed Company, Ltd.
InventorsNorihiko Minoura, Alexandre Rachkov, Tadashi Matsumoto, Kaori Endo, Hu Minjie
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Abstract
The methods for producing macromolecule identifying polymers according to the present invention comprise the steps of polymerizing a starting monomer in an aqueous solution in the presence of a macromolecule, a crosslinking agent, and a radical polymerization initiator to produce a polymer containing the macromolecule in its interior; and removing the macromolecule from the polymer containing the macromolecule to thereby produce the macromolecule identifying polymer having a molecular imprint of the macromolecule. In this method, the crosslinker has a solubility in water at 25° C. of 100% by mass or higher.
Claims16
A macromolecule identifying polymer having a molecular imprint of a macromolecule, comprising a structural unit derived from a vinyl monomer selected from the group consisting of N,N′-dimethylacrylamide, sodium acrylate, and acrylic acid, and a structural unit derived from polyethyleneglycol diacrylate having a solubility in water at 25° C. of 100% by mass or higher, wherein
- said macromolecule identifying polymer changes its volume by 5% or less when it is immersed in water;
- wherein said macromolecule identifying polymer is obtained by a method comprising polymerizing the vinyl monomer in an aqueous solution in the presence of the macromolecule, polyethyleneglycol diacrylate and a radical polymerization initiator to produce a polymer containing the macromolecule in its interior, and removing the macromolecule from the polymer containing the macromolecule to thereby produce the macromolecule identifying polymer having a molecular imprint of the macromolecule;
- and
- wherein said radical polymerization initiator is an azo compound represented by general formula (I)
- wherein R1 and R2 are independently a hydrogen atom or an alkyl group containing 1 to 3 carbon atoms and may be the same or different from each other, or a salt thereof.
Dependencies are inferred from the claim text.