Guanylhydrazones useful for treating diseases associated with T cell activation
AssigneeCytokine PharmaSciences, Inc.
InventorsKevin J. Tracey, Pamela Cohen, Michael Bukrinsky, Helena Schmidtmayerova
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Abstract
There is disclosed a method for treating diseases and disorders involving T cell activation and HIV-infection using the p38 mitogen activated protein kinase (MAPK) signaling pathway as a target for intervention. There is further disclosed a use for guanylhydrazone-substituted compounds to treat diseases and disorders related to T cell activation and HIV-infection.
Claims20
A method for treating HIV, comprising administering an effective HIV-treating amount of a guanylhydrazone-substituted compound to a subject known to have HIV, wherein the guanylhydrazone-substituted compound is CNI-1493.
A method for treating HIV, comprising administering an effective HIV-treating amount of a guanylhydrazone-substituted compound to a subject known to have HIV, wherein the guanylhydrazone-substituted compound has the formula:
- wherein X2=GhyCH—, GhyCCH3— or H—;
- X1, X′1 and X′2, independently=GhyCH— or GhyCCH3—;
- Z=—NH(CO)NH—, —(C6H4)—, —(C5NH3)— or -A-(CH2)n-A-, n=2-10, which is unsubstituted, mono- or di-C-methyl substituted, or a mono or di-unsaturated derivative thereof;
- and A independently=—NH(CO)—, —(CO)NH—, —NH(CO)NH—, —NH— or —O— and salts thereof.
A method for treating HIV, comprising administering an effective HIV-treating amount of a guanylhydrazone-substituted compound to a subject known to have HIV, wherein the guanylhydrazone-substituted compound has the formula:
- wherein X1 and X2=H;
- X′1 and X′2 independently=GhyCH— or GhyCCH3—;
- Z=-A-(CH2)n-A-, n=3-8;
- and A=—NH(CO)—, —(CO)NH— or —NH(CO)NH—;
- and salts thereof.
A method for treating HIV, comprising administering an effective HIV-treating amount of a guanylhydrazone-substituted compound to a subject known to have HIV, wherein the guanylhydrazone-substituted compound has the formula:
- wherein X1, and X2=H;
- X′1 and X′2 independently =GhyCH— or GhyCCH3—, and Z═—O—(CH2)2—O—, and salts thereof.
A method for treating HIV, comprising administering an effective HIV-treating amount of a guanylhydrazone-substituted compound to a subject known to have HIV, wherein the guanylhydrazone-substituted compound has the formula:
- wherein X2=GhyCH—, GhyCCH3— or H—;
- X1, X′1 and X′2=GhyCH— or GhyCCH3—;
- and Z=—O—(CH2)n—O—, n=2-10, and salts thereof.
A method for treating HIV, comprising administering an effective HIV-treating amount of a guanylhydrazone-substituted compound to a subject known to have HIV, wherein the guanylhydrazone-substituted compound has the formula:
- wherein n=3-8;
- X2 and X′2=GhyCH—, GhyCCH3— or H—;
- X1 and X′1=GhyCH— or GhyCCH3—;
- and salts thereof.
Dependencies are inferred from the claim text.