Low pH pharmacologically active products and methods for the production thereof
OwnerLeonard Mackles, William Bessinventors
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Abstract
There is provided a new technology that will allow the formulation of pharmaceutically active organic acid products at relatively high pH during storage. This affords the advantages of avoiding formulation with the acid form of the product, yet when the product is used, the pH will be reduced via a chemical reaction, thus forming the organic acid which is the active form of the product. A by-product of the reaction is a significant increase in temperature, thus adding to the efficacy of the organic acid.
Claims35
A method of providing an in situ prepared pharmacologically active organic acid comprising the step of mixing aqueous Solution “A” containing a salt of said organic acid in the presence of a reducing salt selected from the group consisting of metabisulfites, and hydrosulfites with Solution “B” containing an aqueous solution of a water soluble peroxide.
A method of providing an in situ prepared pharmacologically active organic acid comprising the step of mixing aqueous Solution “A” containing a reducing salt selected from the group consisting of metabisulfites, and hydrosulfites with Solution “B” containing an aqueous solution of a water soluble peroxide and a salt of said organic acid.
A kit for providing an in situ prepared pharmacologically active organic acid comprising:
- an aqueous Solution “A” containing a salt of said organic acid in the presence of a reducing salt selected from the group consisting of metabisulfites and hydrosulfites in the presence of a salt of said organic acid and
- Solution “B” containing an aqueous solution of a water soluble peroxide.
A kit for providing an in situ prepared pharmacologically active organic acid comprising:
- an aqueous Solution “A” containing a reducing salt selected from the group consisting of metabisulfites and hydrosulfites and
- Solution “B” containing an aqueous solution of a water soluble peroxide in the presence of a salt of said organic acid.
Dependencies are inferred from the claim text.