Pyrrole derivatives and their methods of use

A compound of the formula (I):

• or a pharmaceutically acceptable salt, ester, amide thereof, wherein:
• A is a 6-membered aryl ring;
• R1 is —SO2R10;
• R2 is hydrogen or alkyl;
• R3 is —C(O)R12;
• R4 is aryl substituted with 0, 1, 2, 3, 4, or 5 substituents independently elected from acyl, acyloxy, alkenyl, alkoxyalkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxyimino, alkoxysulfonyl, alkyl, alkylcarbonyl, alkylsulfonyl, alkynyl, amino, carboxy, cyano, cyanoalkyl, formyl, haloalkoxy, haloalkyl, halo, hydroxy, hydroxyalkyl, mercapto, nitro, thioalkoxy, —NRARB, (NRARB) alkyl, (NRARB)alkoxy, (NRARB)carbonyl, and (NRARB)sulfonyl, wherein RA and RB are independently selected from hydrogen, alkyl, alkylcarbonyl, alkylsulfonyl, and formyl, or —R14R15;
• R5 is hydrogen, halo, aryl, heteroaryl, bicyclic heteroaryl, —R23—R24, or —R23—C(O)—R24;
• R10 is NR11aR11b;
• R11a and R11b are independently hydrogen or alkyl;
• or R11a and R11b taken together with the nitrogen atom to which each is attached form a 4-, 5-, or 6-membered heterocycle;
• R12 is hydrogen, alkyl, heterocycle, heteroarylalkyl, or —NR16R17,
• R14 is aryl;
• R15 is aryl, heteroaryl, heterocycle or
• R16 and R17 are independently hydrogen, alkyl, alkoxy, alkoxyalkyl, aryl, arylalkyl, cycloalkyl, heteroaryl, heteroarylalkyl, heterocycle, heterocyclealkyl, hydroxyalkyl or R18R19N-alkyl-;
• R18 and R19 are independently hydrogen or alkyl;
• R21 is aryl or heteroaryl;
• R22 is arylalkyl;
• R23 is aryl;
• and
• R24 is heteroaryl or heterocycle.