Back to results
US 7,741,359 B2Granted
Hydrogen sulfide derivatives of non-steroidal anti-inflammatory drugs
AssigneeAntibe Therapeutics Inc.
InventorsJohn Wallace, Giuseppe Cirino, Vincenzo Santagada, Giuseppe Caliendo
Life of this patent
Estimating the term…
Abstract
The present invention relates to derivatives of non-steroidal anti-inflammatory drugs (NSAIDs) having improved anti-inflammatory properties useful in the treatment of inflammation, pain and fever. More particularly, NSAIDs are derivatized with a hydrogen sulfide (H2S) releasing moiety to produce novel anti-inflammatory compounds having reduced side effects.
Claims7
A compound of the formula:
- B—C(O)O—X (Formula II)
- wherein B—C(O)O— is derived from an NSAID having a free carboxyl group, wherein the NSAID is selected from the group consisting of acetylsalicylic acid, diclofenac, indomethacin, lumiracoxib, naproxen, ibuprofen, ketoprofen and flurbiprofen;
- and X is
- or a salt thereof.
1 more element
A compound of the formula:
- or a pharmaceutically acceptable salt thereof.
A compound of the formula:
- or a pharmaceutically acceptable salt thereof.
A compound of the formula:
- or a pharmaceutically acceptable salt thereof.
A compound of the formula:
- or a pharmaceutically acceptable salt thereof.
A compound of the formula:
- or a pharmaceutically acceptable salt thereof.
A compound of the formula:
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.