KCNQ channel modulating compounds and their pharmaceutical use

A compound represented by Formula I

• any of its enantiomers or any mixture of its enantiomers, or a prodrug, or a pharmaceutically-acceptable addition salt thereof, wherein
• R1 represents —CN;
• R2 represents halo, haloalkyl, hydroxyl or alkoxy;
• X represents, NR″ or NR″CH2 (read in the stated direction);
• wherein
• R″ represents hydrogen;
• R4 represents aryl-alkyl, which is substituted one or more times with substituents selected from the group consisting of halo, or methylenedioxy;
• or
• R4 represents a group of formula -Z′-L″-Z″;
• wherein
• Z′ and Z″, independently of one another, represent an aryl group, which aryl may be optionally substituted one or more times with halo;
• and
• L″ represents a single (covalent) bond, or a linker selected from O or OCH2, with the proviso that when X represents NR″, then R4 represents aryl-alkyl and when X represents NR″CH2, then R4 represents a group of formula -Z′-L″-Z″.